Stephen J. Lippard - Cambridge MA John M. Essigmann - Cambridge MA Brian A. Donahue - Menlo Park CA Jeffrey H. Toney - Basking Ridge NJ Suzanne L. Bruhn - Mansfield MA Pieter M. Pil - New Haven CT Steven J. Brown - San Diego CA Patti J. Kellett - West Chester OH
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 4800
US Classification:
435375, 514 44, 424 9321
Abstract:
Methods disclosed herein capitalize on the ability of DNA Structure Specific Recognition Proteins (SSRPs) to bind to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents. Methods are provided for predicting whether an agent that damages DNA will also be cytotoxic, and for predicting whether particular eukaryotic cells will be susceptible to killing by a genotoxic drug. A screening method is provided for identifying new genotoxic drugs that produce SSRP-recognized lesions in DNA. Methods also are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs.
Uses For Dna Structure-Specific Recognition Protein
Stephen J. Lippard - Cambridge MA John M. Essigmann - Brookline MA Brian Donahue - Menlo Park CA Jeffrey H. Toney - Westfield NJ Suzanne L. Bruhn - Cambridge MA Pieter M. Pil - New Haven CT Steven J. Brown - La Jolla CA Patti J. Kellett - Cincinnati OH
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C12N 1500
US Classification:
435 6
Abstract:
Methods disclosed herein capitalize on the ability of DNA Structure Specific Recognition Proteins (SSRPs) to bind to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents. Methods are provided for predicting whether an agent that damages DNA will also be cytotoxic, and for predicting whether particular eukaryotic cells will be susceptible to killing by a genotoxic drug. A screening method is provided for identifying new genotoxic drugs that produce SSRP-recognized lesions in DNA. Methods also are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs.
Isbn (Books And Publications)
Reclaiming the Commons: Community Farms & Forests in a New England Town
Aug 2014 to 2000 Sales/FundraiserCharter Communications Worcester, MA Feb 2013 to May 2014 Broadband TechnicianRoland's Business Systems Worcester, MA May 2008 to Feb 2013 TechnicianGulf Oil
Mar 2007 to Mar 2008 Shift Leader
Education:
Quinsigamond College Worcester, MA Sep 2004 to Dec 2010 Liberal ArtsUniversity of Hartford West Hartford, CT Sep 2003 to May 2004 Liberal ArtsSt John's High School Shrewsbury, MA May 2003 High School Diploma
Sep 2014 to 2000 Operations SpecialistJoe Hehn's Painting and Carpentry Specialists Chelmsford, MA Jun 2011 to Aug 2014 Team LeaderDick's Sporting Goods Hadley, MA Aug 2013 to Apr 2014 Team Sports RepresentativeHorizon Wealth Management
Illinois Bone & Joint Institute 1300 E Central Rd FL 1, Arlington Heights, IL 60005 8478706100 (phone), 8478708159 (fax)
Illinois Bone & Joint Institute 1253 S Rand Rd, Lake Zurich, IL 60047 8474383041 (phone), 8474382868 (fax)
Education:
Medical School University of Michigan Medical School Graduated: 1988
Procedures:
Lower Leg/Ankle Fractures and Dislocations Occupational Therapy Evaluation Arthrocentesis Carpal Tunnel Decompression Hip/Femur Fractures and Dislocations Joint Arthroscopy Knee Arthroscopy Lower Arm/Elbow/Wrist Fractures and Dislocations Shoulder Arthroscopy Shoulder Surgery
Conditions:
Internal Derangement of Knee Cartilage Fractures, Dislocations, Derangement, and Sprains Hallux Valgus Internal Derangement of Knee Internal Derangement of Knee Ligaments
Languages:
English Spanish
Description:
Dr. Donahue graduated from the University of Michigan Medical School in 1988. He works in Arlington Heights, IL and 1 other location and specializes in Orthopaedic Surgery and Orthopedic Sports Medicine. Dr. Donahue is affiliated with Alexian Brothers Medical Center, Northwest Community Hospital and Saint Alexius Medical Center.
Head Elementary School Lilburn GA 1994-1999, Grayson Elementary School Grayson GA 1994-1999, McConnell Middle School Loganville GA 2000-2002, Grayson High School Grayson GA 2002-2006
en Mo Elinzano of Rep. Doris Matsuis (D-Calif.) office John Newton of theSenate Agriculture GOP Tom Collamore Brian Donahue of CRAFT | Media/Digital Geoff Smith of Oklahoma Gov. Kevin Stitts D.C. office former Holyoke, Mass., Mayor Alex Morse Emily Tara Weberman Sam Conchuratt Ki
Date: Jan 29, 2023
Category: U.S.
Source: Google
POLITICO Playbook: My wild day in Wyoming with Matt Gaetz
HAPPY BIRTHDAY: Former Speaker Paul Ryan Rep. Jake Auchincloss (D-Mass.) is 33 Kim Ghattas CNNs Lauren Dezenski Michael Duga Brian Donahue, CEO and founder of CRAFT | Media/Digital Oprah
Date: Jan 29, 2021
Category: Headlines
Source: Google
Providence, out-of-state hospitals prepare to fill gaps left by OHSU heart transplant program
The University of Washington's heart transplant program is the third largest in the country, replacing about 75 hearts last year.It has about 40 people on its waiting list at any given time, said spokesman Brian Donahue.
Brian Donahue, chief executive of Craft Media/Digital, a Washington, D.C., agency focused on campaign advertising, expressed that sentiment to The Seattle Times when the primary campaigns kicked off last year.
Date: Sep 25, 2016
Category: U.S.
Source: Google
Super PAC forms unit to confront Clinton critics on social media
That is what the Clinton campaign has always been about," Brian Donahue, chief executiveof the consulting firm Craft Media/Digital, told The Times. "It runs the risk of being exactly what their opponents accuse them of being: a campaign that appears to be populist but is a smokescreen that is paid
Date: May 10, 2016
Source: Google
Status of local shipments as West Coast ports temporarily suspend work on ships
Weve got a container sitting there now, if it sits there for another two to three weeks, we will have an issue in another month, said Brian Donahue, vice president of Pacific Allied Products.
Fix the Debt is hardly alone. More traditional trade groups like the Business Roundtable have also gotten in the action. The BRT has launched a five-week, $500,000 campaign with media buys and lobbying. The trade association has contracted with NJI Media, CRAFT's Brian Donahue and Fratelli Group.
Date: Dec 09, 2012
Category: U.S.
Source: Google
Newt Gingrich's war on Republican debate moderators
By focusing his attacks on debate moderators, consultants, President Obama and other figures, Gingrich can appear tough without alienating Republican audiences that he needs, and who may be lukewarm on their first-choice candidate, GOP consultant Brian Donahue said.
Date: Nov 10, 2011
Category: U.S.
Source: Google
Youtube
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