Brian J Green

US Patent:

20200181179, Jun 11, 2020

Filed:

Jul 17, 2018

Appl. No.:

16/631963

Inventors:

- Lutherville MD, US
Matthew Richard Oberholzer - Wilmington DE, US
Brian Michael Green - Lutherville MD, US
Samir Kulkarni - East Lyme CT, US
Jennifer Nelson - Kokomo IN, US
Patricia Andres - West Lafayette IN, US

Assignee:

AGRIMETIS, LLC - Lutherville MD

International Classification:

C07F 9/535

Abstract:

Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.