Brian E Hill

US Patent:

6413395, Jul 2, 2002

Filed:

Dec 16, 1999

Appl. No.:

09/465870

Inventors:

Raghbir Singh Bhullar - Indianapolis IN
Jeffery Neal Shelton - Fishers IN
Brian S. Hill - Indianapolis IN

Assignee:

Roche Diagnostics Corporation - Indianapolis IN

International Classification:

G01N 27327

US Classification:

204403, 204409

Abstract:

According to an aspect of the invention a biosensor apparatus is provided, comprising a base, electrodes positioned on the base, a cover including ports, a plate positioned on the base and including apertures in communication with at least one of the electrodes, a cover including ports in communication with the plate and offset from the apertures, and at least one reagent positioned between the plate and the cover. According to a preferred embodiment the plate includes microstructures extending into the ports of the cover.

US Patent:

6447657, Sep 10, 2002

Filed:

Dec 4, 2000

Appl. No.:

09/729296

Inventors:

Raghbir S. Bhullar - Indianapolis IN
Christopher D. Wilsey - Carmel IN
Brian S. Hill - Avon IN

Assignee:

Roche Diagnostics Corporation - Indianapolis TN

International Classification:

G01N 2726

US Classification:

204409, 204403, 204416

Abstract:

A biosensor is provided that includes first and second plate elements, wherein each plate elements has first and second ends and first and second lateral borders. In addition, the biosensor includes a spacer positioned to lie between the first and second plate elements so that at least a portion of the first and second plate elements cooperate with one another to form opposite walls of a capillary space. Further, the first ends and at least a portion of the lateral borders define a fluid sample-receiving portion in communication with the capillary space. Electrodes are positioned in the capillary space of the biosensor.

US Patent:

6485471, Nov 26, 2002

Filed:

Mar 3, 2000

Appl. No.:

09/518817

Inventors:

Maury Zivitz - Indianapolis IN
Raghbir Singh Bhullar - Indianapolis IN
Brian S. Hill - Indianapolis IN

Assignee:

Roche Diagnostics Corporation - Indianapolis IN

International Classification:

A61M 5178

US Classification:

604212, 604216, 604187, 604181, 604200

Abstract:

A fluid-delivery apparatus for delivering a medicament to a patient is provided in accordance with the present invention. The apparatus includes a housing defining a passageway, a bellowed ampoule positioned to lie in the passageway of the housing, and a piston. The bellowed ampoule includes a body with first and second ends and is formed to define a cavity configured to contain the medicament. The piston presses the second end of the ampoule toward the first end to dispense the medicament from the cavity. In addition, the fluid-delivery apparatus includes a visible non-linear scale that represents the relationship between a volume of medicament delivered from the first end of the ampoule and a distance that the piston has traveled in the housing toward the first end.

US Patent:

6488828, Dec 3, 2002

Filed:

Jul 20, 2000

Appl. No.:

09/620191

Inventors:

Raghbir Singh Bhullar - Indianapolis IN
Douglas Paul Walling - Indianapolis IN
Brian S. Hill - Indianapolis IN

Assignee:

Roche Diagnostics Corporation - Indianapolis IN

International Classification:

G01N 27327

US Classification:

20440301, 20440304, 20440314

Abstract:

A recloseable biosensor is provided that comprises a substrate, a sample site positioned on the substrate, and an openable and recloseable cover coupled to the substrate. The cover is operative to selectively block access to the sample site. The cover includes a fixed end coupled to the substrate, an opposite free end, and a middle portion extending across the sample site. The middle portion is releasably and recloseably adhered to the substrate.

US Patent:

6540890, Apr 1, 2003

Filed:

Nov 1, 2000

Appl. No.:

09/704145

Inventors:

Raghbir S. Bhullar - Indianapolis IN
Douglas P. Walling - Indianapolis IN
Brian S. Hill - Avon IN

Assignee:

Roche Diagnostics Corporation - Indianapolis TN

International Classification:

G01N 27327

US Classification:

20440302, 20440301, 20440314, 204416, 422 58

Abstract:

A biosensor is provided that comprises a substrate, a reagent positioned on the substrate, and a cover including a first surface coupled to the substrate and a second surface. The first surface is carved so that it includes a flow channel therein. The flow channel extends over at least a portion of the reagent. In addition, the cover includes secondary channels extending on either side of the channel.

US Patent:

6562210, May 13, 2003

Filed:

Dec 30, 1999

Appl. No.:

09/475904

Inventors:

Raghbir Singh Bhullar - Indianapolis IN
Douglas P. Walling - Indianapolis IN
Brian Hill - Indianapolis IN

Assignee:

Roche Diagnostics Corporation - Indianapolis IN

International Classification:

G01N 27327

US Classification:

20440303, 20440304, 20440302

Abstract:

According to an aspect of the invention, an electrochemical cell for analysis of a sample is provided, comprising a dual electrode having a dielectric strip with electrical conductors on opposite sides. According to a preferred embodiment, the electrochemical cell comprises a base, and a first reagent the proximate the dual electrode. According to a further preferred embodiment, a second reagent is provided proximate the dual electrode. A cover may also be provided comprising a sample aperture. According to a particularly preferred embodiment, the first and second reagents are superposed, and the dual electrode is between the first and second reagents. The dual electrode separates the two and preserves chemical stability until a sample is applied.

US Patent:

6627057, Sep 30, 2003

Filed:

Dec 23, 1999

Appl. No.:

09/471571

Inventors:

Raghbir Singh Bhullar - Indianapolis IN
Brian Hill - Indianapolis IN

Assignee:

Roche Diagnostic Corporation - Indianapolis IN

International Classification:

G01N 27327

US Classification:

20440301, 204416, 204409

Abstract:

A sensor strip comprises an electrode substrate, an electrode set, on the electrode substrate, and microspheres. The sensor strip allows for a smaller sample volume and maintain a more uniform flow profile through the sample channel.

US Patent:

6645359, Nov 11, 2003

Filed:

Oct 6, 2000

Appl. No.:

09/684257

Inventors:

Raghbir S. Bhullar - Indianapolis IN
Christopher D. Wilsey - Carmel IN
Brian S. Hill - Avon IN

Assignee:

Roche Diagnostics Corporation - Indianapolis IN

International Classification:

G01N 27327

US Classification:

20440301, 20440314

Abstract:

A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.