Brian E Jackson

US Patent:

6444661, Sep 3, 2002

Filed:

Nov 23, 1999

Appl. No.:

09/448325

Inventors:

Jacqueline K. Barton - San Marino CA
Brian A. Jackson - Pasadena CA
Brian P. Hudson - Pasadena CA

Assignee:

California Institute of Technology - La Jolla CA

International Classification:

A61K 31555

US Classification:

514185, 514187, 514188, 514288, 514360

Abstract:

Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are treated with such compounds that are capable of catalyzing polynucleotide cleavage with light. Suitable compound include compounds of the formula: where R and R are each independently aryl, heteroaryl, substituted aryl or substituted heteroaryl of 1 to 5 rings, and R is a group of the formula where x and z are each independently an integer from 1 to 4 and y is an integer from 1 to 2, and R , R , and R are each independently Hâ, halo, HOâ, H Nâ, CNâ, O Nâ, HSâ, O Sâ, O SOâ, âCOOH, âCONH , R, ROâ, RNHâ, R R Nâ, RO Sâ, RO SOâ, âCOOR, âCONHR, or âCONR R , where R, R and R are each independently lower alkyl, cycloalkyl, lower alkenyl, lower alkynyl, or phenyl, or two R , R , or R together form a fused aryl ring.

US Patent:

6777405, Aug 17, 2004

Filed:

Sep 3, 2002

Appl. No.:

10/235433

Inventors:

Jacqueline K. Barton - San Marino CA
Brian A. Jackson - Pasadena CA
Brian P. Hudson - Pasadena CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

A61K 31555

US Classification:

514185, 514187, 514188, 514288, 514360

Abstract:

Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are treated with such compounds that are capable of catalyzing polynucleotide cleavage with light. Suitable compound include compounds of the formula: where R and R are each independently aryl, heteroaryl, substituted aryl or substituted heteroaryl of 1 to 5 rings, and R is a group of the formula where x and z are each independently an integer from 1 to 4 and y is an integer from 1 to 2, and R , R , and R are each independently Hâ, halo, HOâ, H Nâ, CNâ, O Nâ, HSâ, O Sâ, O SOâ, âCOOH, âCONH , R, ROâ, RNHâ, R R Nâ, RO Sâ, RO SOâ, âCOOR, âCONHR, or âCONR R , where R, R and R are each independently lower alkyl, cycloalkyl, lower alkenyl, lower alkynyl, or phenyl, or two R , R , or R together form a fused aryl ring.

US Patent:

60310987, Feb 29, 2000

Filed:

Aug 11, 1998

Appl. No.:

9/132357

Inventors:

Jacqueline K. Barton - San Marino CA
Brian A. Jackson - Pasadena CA
Brian P. Hudson - Pasadena CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C07F 1500

US Classification:

546 2

Abstract:

Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are treated with such compounds that are capable of catalyzing polynucleotide cleavage with light. Suitable compound include compounds of the formula: Rh(R. sub. 1)(R. sub. 2)(R. sub. 3). sup. 3+ where R. sub. 1 and R. sub. 2 are each independently aryl, heteroaryl, substituted aryl or substituted heteroaryl of 1 to 5 rings, and R. sub. 3 is a group of the formula ##STR1## where x and z are each independently an integer from 1 to 4 and y is an integer from 1 to 2, and R. sub. 4, R. sub. 5, and R. sub. 6 are each independently H--, halo, HO--, H. sub. 2 N--, CN--, O. sub.

US Patent:

63066017, Oct 23, 2001

Filed:

Nov 22, 1999

Appl. No.:

9/447447

Inventors:

Jacqueline K. Barton - San Marino CA
Brian A. Jackson - Pasadena CA
Brian P. Hudson - Pasadena CA

Assignee:

The California Institute of Technology - Pasadena CA

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are treated with such compounds that are capable of catalyzing polynucleotide cleavage with light. Suitable compound include compounds of the formula: Rh(R. sub. 1)(R. sub. 2)(R. sub. 3). sup. 3+ where R. sub. 1 and R. sub. 2 are each indepenently aryl, heteroaryl, substituted aryl or substituted heteroaryl of 1 to 5 rings, and R. sub. 3 is a group of the formula ##STR1## where x and z are each independently an interger from 1 to 4 and y is an interger from 1 to 2, and R. sub. 4, R. sub. 5, and R. sub. 6 are independently H--, halo, HO--, H. sub. 2 N--, CN--, O. sub.