Brian James Jensen

US Patent:

7075209, Jul 11, 2006

Filed:

Jul 18, 2001

Appl. No.:

10/333302

Inventors:

Larry L. Howell - Orem UT, US
Matthew Parkinson - Ann Arbor MI, US
Brian D. Jensen - Ann Arbor MI, US
Gregory M. Roach - Springville UT, US

Assignee:

Brigham Young University - Provo UT

International Classification:

H02N 1/00
G01P 15/02

US Classification:

310309, 200181, 7351401, 7351421, 7351432

Abstract:

A method for designing and optimnizing compliant mechanisms is provided, in addition to bistable compliant mechanism designs. According to the method, a selected compliant structure may be modeled analytically, and the characteristics of the analytical model may be optimized. Multiple recursive optimization algorithms may be used, for example, to determine the general location of a global optimum, and then to determine the values of the analytical model characteristics that obtain the global optimum or a feasible configuration for the selected compliant structure. Geometric characteristics of the selected compliant structure may be derived from the values of the analytical model characteristics. Bistable compliant designs may have a shuttle disposed between a pair of base members. The shuttle () may be linked to the base members () by a pair of legs (), via flexural pivots.

US Patent:

20100248343, Sep 30, 2010

Filed:

Jun 15, 2010

Appl. No.:

12/816183

Inventors:

Quentin T. Aten - Orem UT, US
Larry L. Howell - Orem UT, US
Brian D. Jensen - Orem UT, US
Sandra Burnett - Saratoga Springs UT, US

International Classification:

C12M 1/00

US Classification:

4352853, 4352831

Abstract:

Devices and methods for constraining or holding a cell are provided. In one aspect, for example, a cellular constraint device is provided. Such a device can include a support surface and at least one constraining arm movably coupled to the support surface. The constraining arm has a first position in which the constraining arm is substantially parallel and substantially adjacent to the support surface. Additionally, at least a portion of the constraining arm is movable away from the support surface to a second position where the constraining arm is operable to constrain a single cell.

US Patent:

20100323419, Dec 23, 2010

Filed:

Jul 9, 2008

Appl. No.:

12/668369

Inventors:

Quentin T. Aten - Orem UT, US
Larry L. Howell - Orem UT, US
Brian D. Jensen - Orem UT, US
Sandra Burnett - Saratoga Spring UT, US

International Classification:

C12N 13/00
C12M 1/42

US Classification:

4351731, 4352851

Abstract:

Systems and methods for manipulating molecular material are provided. In one aspect, for example, a method for manipulating molecular material may include positioning an uncharged needle structure in electrical proximity with a charged molecular material at a first locus in a liquid environment, charging the needle structure such that at least a portion of the charged molecular material becomes associated with the needle structure, moving the needle structure and the first locus relative to one another, and discharging the needle structure to disassociate the charged molecular material at a second locus.

US Patent:

20120295345, Nov 22, 2012

Filed:

May 18, 2012

Appl. No.:

13/475401

Inventors:

Quentin T. Aten - Orem UT, US
Sandra H. Burnett - Saratoga Springs UT, US
Brian D. Jensen - Orem UT, US
Larry L. Howell - Orem UT, US

International Classification:

C12N 5/071
C12M 1/00
C12N 5/07
C12N 5/04
C12N 1/14
C12N 1/16

US Classification:

435348, 4352541, 4352551, 435349, 435410, 435375, 4352831

Abstract:

Systems, devices, and methods for protecting a biological material during delivery into a biological structure are provided. In one aspect, for example, a device for protecting and delivering a preselected biological material into a biological structure can include a lance operable to maintain a charge capable of associating a biological material thereto and at least one protective region formed on or in the lance, where the protective region protects the biological material during delivery into a biological structure.

US Patent:

20120301960, Nov 29, 2012

Filed:

May 24, 2012

Appl. No.:

13/480083

Inventors:

Quentin T. Aten - Orem UT, US
Sandra H. Burnett - Saratoga Springs UT, US
Brian D. Jensen - Orem UT, US
Larry L. Howell - Orem UT, US

Assignee:

Brigham Young University - Provo UT

International Classification:

C12M 1/00
C12N 5/071

US Classification:

435375, 4352831

Abstract:

Systems, devices, and methods for delivering a biological material into a cell are provided. In one example, a lance device for introducing biological material into a cell and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a lance having a tip region and a shaft region, wherein the lance is structurally configured to allow entry and movement of the tip region into the cell along an elongate axis of the tip region and along a focal plane of the microscope. In another example, the lance can be configured to allow substantially horizontal entry and movement of the tip region into the cell.

US Patent:

20130005040, Jan 3, 2013

Filed:

Apr 26, 2012

Appl. No.:

13/456856

Inventors:

Quentin T. Aten - Orem UT, US
Sandra H. Burnett - Saratoga Springs UT, US
Brian D. Jensen - Orem UT, US
Larry L. Howell - Orem UT, US

International Classification:

C12N 15/89
C12M 1/00

US Classification:

435455, 435375, 4352851, 4352831

Abstract:

Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell includes bringing into proximity a lance and a preselected biological material outside of a cell and charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance. The method also includes penetrating an outer portion of the cell with the lance and directing and inserting the lance into an organelle, discharging the lance to release at least a portion of the biological material into the organelle, and withdrawing the lance from the cell.

US Patent:

20130177977, Jul 11, 2013

Filed:

Jun 29, 2012

Appl. No.:

13/539184

Inventors:

Quentin T. Aten - Orem UT, US
Walter Fazio - Albuquerque NM, US
Jason Mathew Lund - Orem UT, US
Gregory H. Teichert - Provo UT, US
Sandra H. Burnett - Saratoga Springs UT, US
Brian D. Jensen - Orem UT, US
Larry L. Howell - Orem UT, US

Assignee:

Brigham Young University - Provo UT

International Classification:

C12M 1/12
C12N 15/89

US Classification:

435325, 4352831

Abstract:

Systems, devices, and methods for restraining a biological structure are provided. In one example, a biological structure restraining device can include a barrier structure, an opening defined in the barrier structure, and at least two contact points positioned adjacent to the opening and oriented to contact the biological structure, wherein the barrier structure and the opening are structurally positioned to receive the cell at the contact points. In another aspect, the device can also include a biological structure manipulator having a structure operable to press the biological structure against the contact points. In yet another aspect, the device can further include a biological structure injector having a structure operable to be inserted through the opening and into the biological structure, wherein the biological structure manipulator is operable to maintain the biological structure against the contact points as the biological structure injector is inserted into the biological structure.

US Patent:

20130177988, Jul 11, 2013

Filed:

Nov 19, 2012

Appl. No.:

13/681260

Inventors:

Brigham Young University - Provo UT, US
Regis A. David - Provo UT, US
Sandra H. Burnett - Saratoga Springs UT, US
Brian D. Jensen - Orem UT, US
Larry L. Howell - Orem UT, US

Assignee:

BRIGHAM YOUNG UNIVERSITY - Provo UT

International Classification:

C12N 13/00

US Classification:

435461, 4351736, 4352831

Abstract:

Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell can include bringing into proximity outside of a cell a lance and a preselected biological material, charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance, and penetrating an outer portion of the cell with the lance and directing and inserting the lance into the cell but outside of the organelle. The method can further include discharging the lance to release at least a portion of the biological material, charging the lance with an opposite polarity and charge sufficient to electrophoretically drive at least a portion of the biological material into the organelle, and withdrawing the lance from the cell.