Brian A Ross

US Patent:

6567684, May 20, 2003

Filed:

Dec 6, 2000

Appl. No.:

09/732362

Inventors:

Thomas L. Chenevert - Ann Arbor MI
Alnawaz Rehemtulla - Plymouth MI
Brian D. Ross - Ann Arbor MI

Assignee:

Regents of the University of Michigan - Ann Arbor MI

International Classification:

A61B 5055

US Classification:

600410, 600419, 600544, 600545, 324309

Abstract:

The invention provides a computer-implemented method for detecting changes in rates of water diffusion in a tissue. The invention also provides a computer program product for use in the detection of changes in rates of water diffusion in a tissue using magnetic resonance imaging (MRI) comprising a computer useable medium comprising a computer readable program code embodied therein, wherein the computer program product is capable of storing and analyzing data input from a MRI device. The invention also provides a computer system, comprising a processor and a computer program product of the invention. The invention also provides a tissue imaging system, comprising a magnetic resonance imaging (MRI) device capable of outputting data to a processor; a processor; and, a computer program product of the invention embodied within the processor.

US Patent:

7007232, Feb 28, 2006

Filed:

Apr 7, 2000

Appl. No.:

09/545316

Inventors:

Brian Dale Ross - Ann Arbor MI, US
Lauren Daniel Stegman - Ann Arbor MI, US
Alnawaz Rehemtulla - Plymouth MI, US

Assignee:

Neoplasia Press, Inc. - Ann Arbor MI

International Classification:

G06F 15/00

US Classification:

715530, 715500, 715505, 715751

Abstract:

An improved method for facilitating the peer review process in scholarly publications is presented. This improved method streamlines and compresses the review process, eliminating unnecessary delays and costs inherent in the traditional process. The present invention implements a computer based manuscript tracking process the uses the World Wide Web to allow ubiquitous access to the manuscript under review. This ubiquitous access works in conjunction with automatic generation of potential reviewers and instant notification to authors, editors, and reviewers of significant milestones in the peer review process. Authors are allowed to communicate with anonymous reviewers to reduce the number of revisions leading to approval. Additionally, multiple authors are allowed to collaborate during the manuscript creation process as well as the manuscript review process. This allows several geographically disperse authors to conveniently co-author a manuscript.

US Patent:

7378078, May 27, 2008

Filed:

Jun 2, 2003

Appl. No.:

10/452184

Inventors:

Brian D. Ross - Ann Arbor MI, US
Alnawaz Rehemtulla - Plymouth MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

A61K 49/00
A61K 38/48
A61B 5/00
A01N 63/00
C12P 21/04
C12N 15/00
C12N 5/00

US Classification:

424 91, 424 9321, 424 96, 424 931, 424 9463, 435 697, 4353201, 435325, 435455

Abstract:

The invention provides compositions and methods for non-invasive imaging of enzyme (e. g. , protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The invention provides a chimeric polypeptide having a bioluminescent or chemiluminescent polypeptide, or a heterologous kinase, and at least one silencing moiety, and a protease cleavage motif positioned between the first and second domains. The imaging can be by computer assisted tomography (CAT), magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), or bioluminescence imaging (BLI).

US Patent:

7539938, May 26, 2009

Filed:

Jan 20, 2006

Appl. No.:

11/336489

Inventors:

Brian Dale Ross - Ann Arbor MI, US
Lauren Daniel Stegman - Ann Arbor MI, US
Alnawaz Rehemtulla - Plymouth MI, US

Assignee:

Neoplasia Press, Inc. - Ann Arbor MI

International Classification:

G06F 17/00

US Classification:

715255, 715200, 715751, 715221

Abstract:

An improved method for facilitating the peer review process in scholarly publications is presented. This improved method streamlines and compresses the review process, eliminating unnecessary delays and costs inherent in the traditional process. The present invention implements a computer based manuscript tracking process the uses the World Wide Web to allow ubiquitous access to the manuscript under review. This ubiquitous access works in conjunction with automatic generation of potential reviewers and instant notification to authors, editors, and reviewers of significant milestones in the peer review process. Authors are allowed to communicate with anonymous reviewers to reduce the number of revisions leading to approval. Additionally, multiple authors are allowed to collaborate during the manuscript creation process as well as the manuscript review process. This allows several geographically disperse authors to conveniently co-author a manuscript.

US Patent:

8185186, May 22, 2012

Filed:

Apr 11, 2008

Appl. No.:

12/101753

Inventors:

Brian D. Ross - Ann Arbor MI, US
Alnawaz Rehemtulla - Plymouth MI, US
Thomas L. Chenevert - Ann Arbor MI, US
Charles R. Meyer - Ann Arbor MI, US
Kuei C. Lee - San Antonio TX, US
Kenneth Pienta - Ann Arbor MI, US
Maha Hussein - Ann Arbor MI, US
Anne Schott - Ann Arbor MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

A61B 5/055
G06K 9/00

US Classification:

600410, 382128

Abstract:

The present invention provides systems and methods for monitoring tissue regions. In particular, the present invention provides systems and methods for detecting changes in tissue regions over a period of time. In some embodiments, the systems and methods of the present invention are used to evaluate the effectiveness of a particular treatment of a tissue region. In some embodiments, the systems and methods employ functional diffusion map algorithms for imaging changes in tissue regions over time and/or in response to therapeutic interventions.

US Patent:

8404121, Mar 26, 2013

Filed:

Aug 11, 2009

Appl. No.:

12/462878

Inventors:

Joel Bias - Southgate MI, US
Brian Ross - Lansing MI, US

Assignee:

Anaergia Inc. - Burlington, Ontario

International Classification:

C02F 1/24

US Classification:

210703, 210744, 210109, 210143, 2102211

Abstract:

The disclosure relates to a separation process. An aerated inlet mixture of fluid and solids is fed to a flotation separation vessel and is separated into an upper float layer and a lower clarified layer. The upper float layer is withdrawn from the vessel when the height of the upper float layer exceeds the height of an overflow conduit and forms a concentrated solids effluent. The lower clarified layer is withdrawn from the separation vessel as a clarified fluid effluent. The separation process is performed continuously using a control process that maintains a relatively stable distribution between the lower clarified layer and the upper float layer. The control process is a closed loop process that monitors the instantaneous height of the vessel contents and computes an error function based on the instantaneous height and a set-point height. The error function is used to periodically adjust the outlet flowrate of the clarified fluid effluent. The resulting process has improved stability (e. g.

US Patent:

20020073441, Jun 13, 2002

Filed:

Dec 13, 2000

Appl. No.:

09/737255

Inventors:

Brian Ross - Ann Arbor MI, US
Alnawaz Rehemtulla - Plymouth MI, US

International Classification:

A01K067/027
C12Q001/00
C07H021/04
C12N009/02
C12N005/06

US Classification:

800/018000, 435/004000, 435/189000, 536/023200, 530/350000, 435/354000

Abstract:

The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The invention provides a chimeric polypeptide having a bioluminescent or chemiluminescent polypeptide, or a heterologous kinase, and at least one silencing moiety, and a protease cleavage motif positioned between the first and second domains. The imaging can be by computer assisted tomography (CAT), magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), or bioluminescence imaging (BLI).

US Patent:

20020122806, Sep 5, 2002

Filed:

Mar 5, 2001

Appl. No.:

09/734628

Inventors:

Arul Chinnaiyan - Canton MI, US
Alnawaz Rehemtulla - Plymouth MI, US
Brian Ross - Ann Arbor MI, US

International Classification:

A61K039/395
C07H021/04

US Classification:

424/178100, 435/325000, 536/023500

Abstract:

The invention provides compositions and methods for imaging cells and tissues in vivo and in situ. Compositions and methods are provided for administration to enhance the imaging of cells and tissues by, e.g., computer assisted tomography (CAT), magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), or bioluminescence imaging (BLI). Thus, the invention provides compositions and methods for identifying sites of primary and metastatic tumors and tumor neovasculature.