Brian M Whitaker

US Patent:

20100021477, Jan 28, 2010

Filed:

Aug 25, 2009

Appl. No.:

12/546850

Inventors:

Ping Tsui - Berwyn PA, US
Lei Shi - Radnor PA, US
Jin Lu - Radnor PA, US
John Wheeler - Radnor PA, US
Brian Whitaker - Radnor PA, US
Lionella Borozdina-Birch - San Diego CA, US
Juan C. Almagro - Radnor PA, US
Bernard Amegadzie - Radnor PA, US
Mark Tornetta - Radnor PA, US
Ramachandra Reddy - Radnor PA, US
David M. Knight - Radnor PA, US
Jinquan Luo - Radnor PA, US
Raymond W. Sweet - Radnor PA, US
Qiang Chen - San Diego CA, US

International Classification:

A61K 39/40
C12N 15/63
C12N 1/21
C07K 14/195
C07K 16/12
C40B 40/02
C40B 30/04

US Classification:

4241641, 4353201, 4352523, 530350, 5303871, 506 14, 506 9

Abstract:

Described and claimed herein are combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were built on scaffolds representing the most frequently used genes in human antibodies, which were diversified to mirror the variability of natural antibodies. After selection using a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. By a process called in-line maturation the affinity of some antibodies was improved up to one hundred-fold yielding low pM binders suitable for in vivo use. This work thus demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the foundations for studies on the structure-function relationship of antibodies.

US Patent:

20220348647, Nov 3, 2022

Filed:

Jun 29, 2022

Appl. No.:

17/853218

Inventors:

- Horsham PA, US
Alfred Del Vecchio - Spring House PA, US
John Kehoe - Spring House PA, US
Eilyn Lacy - Spring House PA, US
Lynne Murray - Melbourn, GB
Mary Ryan - Spring House PA, US
John Wheeler - Spring House PA, US
Brian Whitaker - Spring House PA, US
Alexey Teplyakov - Spring House PA, US

International Classification:

C07K 16/24

Abstract:

The present invention relates to antibodies specifically binding CCL17, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.

US Patent:

20210017267, Jan 21, 2021

Filed:

Oct 1, 2020

Appl. No.:

17/060362

Inventors:

- Horsham PA, US
Alfred Del Vecchio - Spring House PA, US
John Kehoe - Spring House PA, US
Eilyn Lacy - Spring House PA, US
Lynne Murray - Melbourn, GB
Mary Ryan - Spring House PA, US
John Wheeler - Spring House PA, US
Brian Whitaker - Spring House PA, US
Alexey Teplyakov - Spring House PA, US

International Classification:

C07K 16/24

Abstract:

The present invention relates to antibodies specifically binding CCL17, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.

US Patent:

20190062420, Feb 28, 2019

Filed:

Aug 24, 2018

Appl. No.:

16/111360

Inventors:

- Horsham PA, US
Brian Whitaker - Exton PA, US
Di Zhang - Hillsborough NJ, US

International Classification:

C07K 16/24
A61P 35/00
C07K 16/28

Abstract:

FN3 domains that specifically bind FcγRII, their conjugates and antibody fusions, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them.

US Patent:

20180171007, Jun 21, 2018

Filed:

Dec 8, 2017

Appl. No.:

15/835529

Inventors:

- Horsham PA, US
Alfred Del Vecchio - Spring House PA, US
John Kehoe - Spring House PA, US
Eilyn Lacy - Spring House PA, US
Lynne Murray - Melbourn, GB
Mary Ryan - Spring House PA, US
John Wheeler - Spring House PA, US
Brian Whitaker - Spring House PA, US
Alexey Teplyakov - Spring House PA, US

International Classification:

C07K 16/24
A61K 39/00

Abstract:

The present invention relates to antibodies specifically binding CCL17, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.

US Patent:

20170233461, Aug 17, 2017

Filed:

May 2, 2017

Appl. No.:

15/584235

Inventors:

- New York NY, US
- Horsham PA, US
Anthony LYNCH - Spring House PA, US
William STROHL - Spring House PA, US
Brian WHITAKER - Spring House PA, US
Mark CHIU - Spring House PA, US
Peter T. BUCKLEY - Spring House PA, US
Keri DORN - Spring House PA, US
Michelle KINDER - Spring House PA, US

International Classification:

C07K 16/12
C07K 14/78

Abstract:

The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a infection, including methicillin-resistant

US Patent:

20150210756, Jul 30, 2015

Filed:

Dec 9, 2014

Appl. No.:

14/565069

Inventors:

- New York NY, US
- Horsham PA, US
Anthony Lynch - Spring House PA, US
William Strohl - Spring House PA, US
Brian Whitaker - Spring House PA, US
Mark Chiu - Spring House PA, US
Peter T. Buckley - Spring House PA, US
Keri Dorn - Spring House PA, US
Michelle Kinder - Spring House PA, US

International Classification:

C07K 16/12
G01N 33/569

Abstract:

The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a infection, including methicillin-resistant

US Patent:

20150125458, May 7, 2015

Filed:

Nov 6, 2014

Appl. No.:

14/534525

Inventors:

- Horsham PA, US
Alfred Del Vecchio - Spring House PA, US
John Kehoe - Spring House PA, US
Eilyn Lacy - Spring House PA, US
Lynne Murray - Melbourn, GB
Mary Ryan - Spring House PA, US
John Wheeler - Spring House PA, US
Brian Whitaker - Spring House PA, US
Alexey Teplyakov - Spring House PA, US

International Classification:

C07K 16/24

US Classification:

4241391, 5303879, 5303873, 536 2353, 4353201, 435419, 435 696, 43525233, 43525231, 4352523, 43525234, 4352542, 43525421, 43525423, 435331

Abstract:

The present invention relates to antibodies specifically binding CCL17, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.