Bruce Albert Malcolm

age ~67

from Bayside, NY

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Also known as:

Bruce A Malcolm
Bruce A Malcom
Bruce A Howe
Paul B Farrey
Loretta A Knox

Phone and address:: 2836 210Th Pl, Flushing, NY 11360

Connected to:

Bruce Malcolm Phones & Addresses

2836 210Th Pl, Bayside, NY 11360
Springfield, NJ
344 Paoli Woods, Paoli, PA 19301
Westfield, NJ
Newton, MA
Oakland, CA
Berkeley, CA
Chester, PA

Work

Company:

Elizabeth truck center inc.
Address:

888 North Ave E, Elizabeth, NJ 07201
Phones:

9083559200
Position:

Finance executive
Industries:

Top, Body, and Upholstery Repair Shops and Paint Shops

Resumes

Senior Director Drug Discovery And Early

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Location:

Springfield, NJ

Industry:

Pharmaceuticals

Work:

Senior Director Drug Discovery and Early
Tibotec
Senior Director Drug Discovery and Early Development, Infectious Diseases and Vaccines
Wyeth Collegeville Pa 2005 - 2008
Research Fellow, Cardiovascular and Metabolic Diseases
Schering-Plough Research Institute 1997 - 2005
Senior Research Fellow, Anti-Infectives Division

Education:

University of California, Berkeley
Doctorates, Doctor of Philosophy, Biochemistry

Skills:

Drug Discovery
Infectious Diseases
Vaccines
Metabolism
Lifesciences
Drug Development
Biotechnology
Clinical Development
Pharmaceutical Industry
Medicinal Chemistry
Molecular Biology
Virology
Immunology
Protein Chemistry
Assay Development
Elisa
Drug Design
High Throughput Screening
In Vitro
Cell
Biochemistry
Pharmacology
In Vivo

Bruce Malcolm

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Bruce Malcolm

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Bruce Malcolm

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Bruce Malcolm

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Bruce Malcolm

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Bruce Malcolm

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Bruce Malcolm

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Name / Title

Company / Classification

Phones & Addresses

Bruce Malcolm
Finance Executive

Elizabeth Truck Center Inc.
Top, Body, and Upholstery Repair Shops and Pa...

888 North Ave E, Elizabeth, NJ 07201

Bruce Malcolm
Chief Financial Officer

Elizabeth Truck Center Inc.
Local Trucking With Storage

888 North Ave E, Elizabeth, NJ 07201

888 N North Ave E, Elizabeth, NJ 07201

Bruce J Malcolm
Director

MALCOLM AVIATION CONSULTING, INC

Bruce Malcolm
MM

EA2000, LLC

Bruce J. Malcolm
General Partner

Tne Limited Partnership
Holding Company

Us Patents

Single-Chain Recombinant Complexes Of Hepatitis C Virus Ns3 Protease And Ns4A Cofactor Peptide
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US Patent:

6653127, Nov 25, 2003
Filed:

Oct 6, 2000
Appl. No.:

09/684881
Inventors:

Bruce A. Malcolm - Westfield NJ
S. Shane Taremi - Upper Montclair NJ
Patricia C. Weber - Yardley PA
Nanhua Yao - Irvine CA
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

C12N 1574
US Classification:

4353201, 435 691, 435 697, 435219, 536 232, 536 2372, 536 242
Abstract:

Covalent HCV NS4A-NS3 complexes comprising the central hydrophobic domain of native HCV NS4A peptide, a linker, and the HCV NS3 serine protease domain, wherein the hydrophobic domain of native HCV NS4A peptide is tethered by the linker to the amino terminus of the HCV NS3 protease domain.

Diaryl Peptides As Ns3-Serine Protease Inhibitors Of Hepatitis C Virus
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US Patent:

6911428, Jun 28, 2005
Filed:

Dec 10, 2001
Appl. No.:

10/013071
Inventors:

Zhaoning Zhu - East Windsor NJ, US
Srikanth Venkatraman - Woodbridge NJ, US
F. George Njoroge - Warren NJ, US
Ashok Arasappan - Bridgewater NJ, US
Bruce A. Malcolm - Westfield NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Raymond G. Lovey - West Caldwell NJ, US
Kevin X. Chen - Iselin NJ, US
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

A61K038/17
A61K031/33
C07K007/64
US Classification:

514 9, 530317, 540455, 514183
Abstract:

The present invention is directed to certain diaryl amide compounds as NS3-Serine protease inhibitors of hepatitis C virus. A particularly preferred compound is of the formula:.

Codon-Optimized Β-Secretase And Methods Of Refolding And Processing
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US Patent:

7166454, Jan 23, 2007
Filed:

May 22, 2003
Appl. No.:

10/443949
Inventors:

Brian M. Beyer - Lincroft NJ, US
Bruce A. Malcolm - Westfield NJ, US
Corey O. Strickland - Martinsville NJ, US
Wenyan Wang - Edison NJ, US
Eileen Wilson - Raritan NJ, US
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

C12N 9/48
C12N 15/00
C12N 1/20
C12N 1/14
C12N 5/10
C12N 5/00
C07H 21/04
US Classification:

435212, 536 232, 4353201, 4352523, 43525411, 435419, 435325, 43525233
Abstract:

The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. Polypeptides used herein are derived from human BACE which is also known by the synonyms “mamapsin 2”, “human β-site APP-cleaving enzyme, and Asp2”. The present application also relates to crystalline forms of uncomplexed BACE and the three-dimensional structure of BACE, as determined from the crystals. In addition, the present application relates to the use of crystalline forms of BACE to identify ligands, preferably inhibitors (antagonists), which bind to, and preferably inhibit the enzymatic activity of, BACE. Furthermore, the present application relates to nucleic acid sequences encoding BACE polypeptide, and methods for making BACE in greater quantity than prior methods, resulting in more effective crystallization.

Treatments For Virus Infection
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US Patent:

7524831, Apr 28, 2009
Filed:

Mar 1, 2006
Appl. No.:

11/365008
Inventors:

Bruce A. Malcolm - Westfield NJ, US
Robert Palermo - New York NY, US
Xiao Tong - East Brunswick NJ, US
Boris Feld - New Milford NJ, US
Hung Le - Rockaway NJ, US
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

A01N 43/04
A61K 31/70
US Classification:

514 49, 514 42, 514 43, 514 52
Abstract:

The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.

Method For Making Β-Secretase Co-Crystals Complexed With A Ligand
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US Patent:

7569391, Aug 4, 2009
Filed:

Dec 6, 2006
Appl. No.:

11/634737
Inventors:

Brian M. Beyer - Lincroft NJ, US
Bruce A. Malcolm - Paoli PA, US
Corey O. Strickland - Martinsville NJ, US
Wenyan Wang - Edison NJ, US
Eileen Wilson - Raritan NJ, US
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

G01N 31/00
G01N 33/00
US Classification:

436 4, 435183, 117927
Abstract:

The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. The present application also relates to crystalline forms of uncomplexed BACE and the three-dimensional structure of BACE, as determined from the crystals. In addition, the present application relates to the use of crystalline forms of BACE to identify ligands, preferably inhibitors (antagonists), which bind to, and preferably inhibit the enzymatic activity of, BACE. Furthermore, the present application relates to nucleic acid sequences encoding human BACE polypeptide, and methods for making BACE in greater quantity than prior methods, resulting in more effective crystallization.

Pharmaceutical Formulations And Methods Of Treatment Using The Same
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US Patent:

7772178, Aug 10, 2010
Filed:

May 31, 2006
Appl. No.:

11/444078
Inventors:

Bruce A. Malcolm - Paoli PA, US
Prudence K. Bradley - Cranford NJ, US
Anastasia Pavlovsky - Morris Plains NJ, US
Wing-Kee Philip Cho - Princeton NJ, US
Zhihui Qiu - Bridgewater NJ, US
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

A61K 38/12
US Classification:

514 2, 514 9, 514 16, 514 17, 514 18
Abstract:

Pharmaceutical formulations containing at least one compound of Formulae I-XXVI herein and at least one surfactant. Pharmaceutically acceptable carriers and excipients may also be included in the formulations. The formulations of the present invention are suited for use in single unit dosages.

Treatments For Flaviviridae Virus Infection
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US Patent:

7816339, Oct 19, 2010
Filed:

Mar 27, 2009
Appl. No.:

12/412967
Inventors:

Bruce A. Malcolm - Paoli PA, US
Robert Palermo - Seattle WA, US
Xiao Tong - Short Hills NJ, US
Boris Feld - New Milford NJ, US
Hung Le - Rockaway NJ, US
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

A01N 43/04
A61K 31/70
US Classification:

514 49, 514 42, 514 43, 514 52
Abstract:

The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.

Refolded Recombinant Β-Secretase Crystals And Methods For Preparing And Using The Same
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US Patent:

8063185, Nov 22, 2011
Filed:

May 4, 2009
Appl. No.:

12/434897
Inventors:

Brian M. Beyer - Matawan NJ, US
Bruce A. Malcolm - Paoli PA, US
Corey O. Strickland - Martinsville NJ, US
Wenyan Wang - Edison NJ, US
Eileen Wilson - Raritan NJ, US
Assignee:

Schering Corp. - Kenilworth NJ
International Classification:

C12N 1/12
US Classification:

530380
Abstract:

The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. The present application also relates to crystalline forms of uncomplexed BACE and the three-dimensional structure of BACE, as determined from the crystals. In addition, the present application relates to the use of crystalline forms of BACE to identify ligands, preferably inhibitors (antagonists), which bind to, and preferably inhibit the enzymatic activity of, BACE. Furthermore, the present application relates to nucleic acid sequences encoding BACE polypeptide, and methods for making BACE in greater quantity than prior methods, resulting in more effective crystallization.