Bruce S Simon

US Patent:

6955642, Oct 18, 2005

Filed:

Nov 26, 2002

Appl. No.:

10/304721

Inventors:

Bruce J. Simon - Mountain Lakes NJ, US

Assignee:

EBI, LP - Parsippany NJ

International Classification:

A61N001/00

US Classification:

600 14, 607 50

Abstract:

A noninvasive method and apparatus for treating living tissue with pulsed electromagnetic fields (PEMFs) having selectively reduced high-frequency signal components, with improved bioresponse provided by magnetic field amplitudes less than approximately 40 μT, and most preferably in the range of 4–10 μT. Such amplitude levels for the disclosed PEMF signal are particularly effective with a treatment duration in the range of 0. 25–2 hours/day.

US Patent:

7010353, Mar 7, 2006

Filed:

Jan 7, 2002

Appl. No.:

10/041850

Inventors:

Jean C. Gan - Morris Township NJ, US
Bruce J. Simon - Mountain Lakes NJ, US
Jay Penchina - Allendale NJ, US

Assignee:

EBI, L.P. - Parsippany NJ

International Classification:

A61N 1/36

US Classification:

607 50, 607 76

Abstract:

A method for treating a soft tissue wound is provided and includes the steps of providing a signal generator in electrical communication with first and second electrodes, disposing the first and second electrodes on a skin surface on opposing sides of the soft tissue wound and applying an electric field in the soft tissue wound by generating a voltage at a frequency within a range of 20 to 100 kHz and having a symmetrical waveform with an amplitude within a range of 0. 1 to 20 volts peak to peak through said first and second electrodes. In accordance with a first preferred embodiment the signal generator is an AC generator generating a sine wave voltage and in accordance with second and third preferred embodiments, the signal generator is a bipolar DC generator, all generating a symmetrical waveform at a frequency of 60 kHz, with an amplitude of about 5 volts peak to peak.

US Patent:

7520849, Apr 21, 2009

Filed:

Sep 20, 2004

Appl. No.:

10/945291

Inventors:

Bruce J. Simon - Mountain Lakes NJ, US

Assignee:

EBI, LP - Parsippany NJ

International Classification:

A61N 1/00

US Classification:

600 14

Abstract:

A pulsed electromagnetic field method of treating a soft tissue wound, wherein, in one embodiment, a patient in need of treatment for a soft tissue wound is administered a pulsed electromagnetic field (PEMF) having repetitive pulse bursts less than approximately 30 ms in duration, with a pulse burst repetition rate greater than approximately 5 Hz, the pulse bursts generated with a drive signal including pulses each having a first-polarity portion with a pulse width less than 1 ms and a second-polarity portion with a shorter pulse width, the electromagnetic field having a maximum amplitude less than approximately 4 mT and rising to its maximum amplitude during the first-polarity portion. According to another aspect of the invention, a soft tissue wound is treated by administering a pulsed electromagnetic field having substantially unipolar magnetic field pulses generated with a drive signal including a series of pulses each having a first-polarity portion with a pulse width less than 1 ms and a second-polarity portion with a longer pulse width, the electromagnetic field having a maximum amplitude less than 4 mT and rising to its maximum amplitude during the first-polarity portion.

US Patent:

7621963, Nov 24, 2009

Filed:

Apr 11, 2006

Appl. No.:

11/402312

Inventors:

Bruce J. Simon - Mountain Lakes NJ, US
Robert M. Ronk - Pierceton IN, US
Paul D'Antonio - Morristown NJ, US
Jeffrey D. Schwardt - Palo Alto CA, US

Assignee:

EBI, LLC - Parsippany NJ

International Classification:

A61F 2/28

US Classification:

623 2361, 623 2356, 623 2358, 623 1611, 623 2362, 623 2363, 424682, 424422, 424426

Abstract:

A bone graft material comprising about 50-90% quickly bioresorbable porogen particles and about 10-50% of a calcium matrix material. A bioactive substance can be included in the matrix material, the porogen particles, or both. Commercial packages containing the bone graft materials and methods for repairing bone therewith are also claimed.

US Patent:

7744869, Jun 29, 2010

Filed:

Nov 7, 2005

Appl. No.:

11/268696

Inventors:

Bruce Simon - Mountain Lakes NJ, US

Assignee:

EBI, LLC - Parsippany NJ

International Classification:

A01N 65/00
C12N 5/00
C12N 5/02

US Classification:

424 937, 424 931, 435325

Abstract:

Methods of modifying stem cells and compositions of modified stem cells, in particular mesenchymal stem cells, using electric or electromagnetic fields. In various embodiments, the present invention's methods are for the treatment of a human or other mammal subject in need thereof, comprising providing an in vitro culture comprising mesenchymal stem cells, administering an electric stimulation to the in vitro culture, and implanting the mesenchymal stem cells into the subject. Methods also include treatment of a human or other mammal subject, comprising implanting mesenchymal stem cells into the subject, and administering an electric stimulation to the mesenchymal stem cells in situ. Other embodiments include methods of administering electric stimulation in conjunction with growth factors to stem cells.

US Patent:

8041428, Oct 18, 2011

Filed:

Nov 4, 2009

Appl. No.:

12/612177

Inventors:

Joseph P. Errico - Green Brook NJ, US
Bruce Simon - Mountain Lakes NJ, US
Steven Mendez - Brookside NJ, US

Assignee:

ElectroCore LLC - Morris Plains NJ

International Classification:

A61N 1/00

US Classification:

607 44

Abstract:

The present invention includes methods and devices for treating hypotension, such as in cases of shock, including septic shock, anaphylactic shock and hypovolemia. The method includes the step of applying at least one electrical impulse to at least one selected region of a parasympathetic nervous system of the patient. The electrical impulse is sufficient to modulate one or more nerves of the parasympathetic nervous system to increase the ratio of blood pressure to heart rate and relieve the condition and/or extend the patient's life.

US Patent:

8082038, Dec 20, 2011

Filed:

Jul 7, 2005

Appl. No.:

11/176588

Inventors:

Bruce J. Simon - Mountain Lakes NJ, US
Jean C. Gan - Morris Township NJ, US

Assignee:

EBI, LLC - Parsippany NY

International Classification:

A61N 1/32

US Classification:

607 43

Abstract:

A method for treatment of degenerative disc disease using capacitively coupled electrical stimulation. In one embodiment, a subject diagnosed as having degenerative disc disease is treated by placing first and second electrodes on the subject's body at the site of an identified disc in a state of degenerative disc disease, and applying an electric field to the identified disc via the first and second electrodes with the intent to treat the degenerative disc disease. The electric field is created with an electrical signal having a frequency within a range of 20 to 100 kHz and having a symmetrical waveform with an amplitude within a range of 0. 1 to 20 volts peak-to-peak, preferably a frequency of approximately 60 kHz and an amplitude of approximately 5 volts peak-to-peak.

US Patent:

8142774, Mar 27, 2012

Filed:

Jun 1, 2010

Appl. No.:

12/791333

Inventors:

Bruce Simon - Mountain Lakes NJ, US

Assignee:

EBI, LLC - Parsippany NJ

International Classification:

A01N 63/00
A01N 65/00
C12N 5/00
C12N 5/02

US Classification:

424 937, 424 931, 435325

Abstract:

Methods of modifying stem cells and compositions of modified stem cells, in particular mesenchymal stem cells, using electric or electromagnetic fields. In various embodiments, the present invention's methods are for the treatment of a human or other mammal subject in need thereof, comprising providing an in vitro culture comprising mesenchymal stem cells, administering an electric stimulation to the in vitro culture, and implanting the mesenchymal stem cells into the subject. Methods also include treatment of a human or other mammal subject, comprising implanting mesenchymal stem cells into the subject, and administering an electric stimulation to the mesenchymal stem cells in situ. Other embodiments include methods of administering electric stimulation in conjunction with growth factors to stem cells.