Bryan T O'Hara

US Patent:

20010039348, Nov 8, 2001

Filed:

Apr 30, 2001

Appl. No.:

09/845428

Inventors:

Jonathan Bloom - Nyack NY, US
Kevin Curran - Nyack NY, US
Martin DiGrandi - Piermont NY, US
Russell Dushin - Garrison NY, US
Stanley Lang - Carlsbad CA, US
Emily Norton - Nyack NY, US
Adma Ross - Rockland NY, US
Bryan O'Hara - Norwood NJ, US

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

C07D217/12
C07D215/12

US Classification:

546/139000, 546/176000, 558/418000, 564/027000

Abstract:

Compounds having the formula: wherein R-Rare independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO, —COR, —COR, —OR, —SR, —SOR, —SOR, —CONRR, —NRN(RR), —N(RR) or W-Y-(CH)-Z provided that at least one of R-Ris not hydrogen; or Rand Ror Rand R, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; Rand Rare independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; Ris hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or Rand R, taken together may form a 3 to 7 membered heterocycloalkyl; W is O, NR, or is absent; Y is —(CO)— or —(CO)—, or is absent; Z is alkyl of 1 to 4 carbon atoms, —CN, —COR, COR, —CONRR, —OCOR, —NRCOR, —OCONR, —OR, —SR, —SOR, —SOR, SR6N(R7R8), —N(RR) or phenyl; G is aryl or fused bicyclic heteroaryl; X is a bond, —NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

US Patent:

20020026055, Feb 28, 2002

Filed:

Mar 12, 2001

Appl. No.:

09/804510

Inventors:

Jonathan Bloom - Nyack NY, US
Martin DiGrandi - Piermont NY, US
Russell Dushin - Garrison NY, US
Stanley Lang - Carlsbad CA, US
Bryan O'Hara - Norwood NJ, US

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

C 07D 4 1/02
C07D213/44

US Classification:

546/262000, 546/279100, 546/308000

Abstract:

Compounds of the formula wherein A is heteroaryl; R-Rare independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R, and Ror Rand Rmay be taken together to form aryl of 5 to 7 carbon atoms; W is O, NR, or is absent; G is aryl or heteroaryl; and X is a bond X is a bond, —NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; and J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or a pharmaceutical salt thereof, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

US Patent:

20030007983, Jan 9, 2003

Filed:

Dec 6, 2001

Appl. No.:

10/006626

Inventors:

Stephen Goff - Tenafly NJ, US
Gilda Tachedjian - East Malvern, AU
Bryan O'Hara - Norwood NJ, US

International Classification:

C12Q001/70
C12P021/06
C12P019/34
A61K039/00
A61K039/38
A61K039/21

US Classification:

424/208100, 424/207100, 424/184100, 435/005000, 435/091100, 435/069100

Abstract:

This invention provides methods of determining whether a compound inhibits HIV-1 reverse transcriptase. This invention provides methods of determining whether a compound inhibits formation of a complex between a p66 and p51 subunit polypeptides of HIV-1 reverse transcriptase. This invention provides a method of determining whether a compound enhances formation of a complex between a p66 and p51 subunit polypeptides of HIV-1 reverse transcriptase. This invention provides methods of determining whether a compound inhibits formation of a complex between two p66 subunit polypeptides of HIV-1 reverse transcriptase. This invention provides methods of determining whether a compound enhances formation of a complex between two p66 subunit polypeptides of HIV-1 reverse transcriptase.

US Patent:

20030036653, Feb 20, 2003

Filed:

Mar 15, 2002

Appl. No.:

10/099695

Inventors:

Jonathan Bloom - Nyack NY, US
Martin DiGrandi - Piermont NY, US
Russell Dushin - Garrison NY, US
Stanley Lang - Carlsbad CA, US
Bryan O'Hara - Norwood NJ, US

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

C07D217/14
C07D215/14
C07D223/16
C07D209/04

US Classification:

546/146000, 546/175000, 540/593000, 548/503000, 560/016000

Abstract:

Compounds of the formula R-Rare independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO, —COR, —COR, —OR, —SR, —SOR, —SOR, —CONRR, —NRN(RR), —(RR) or W—Y—(CH)—Z; or Rand Ror Rand R, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; Rand Rare independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; Ris hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or Rand R, taken together may form a 3 to 7 membered heterocycloalkyl; A is heteroaryl;

US Patent:

62077155, Mar 27, 2001

Filed:

Nov 22, 1999

Appl. No.:

9/444897

Inventors:

Jonathan Bloom - Nyack NY
Kevin Curran - Nyack NY
Martin DiGrandi - Piermont NY
Russell Dushin - Garrison NY
Stanley Lang - Carlsbad CA
Emily Norton - Nyack NY
Adma Ross - Suffern NY
Bryan O'Hara - Norwood NJ

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

A01N47/28

US Classification:

514580

Abstract:

Compounds of the formula: ##STR1## are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpes virus.

US Patent:

56333480, May 27, 1997

Filed:

Jan 4, 1996

Appl. No.:

8/582719

Inventors:

Stephen V. Johann - Pearl River NY
Marja van Zeijl - Cornwall NY
Bryan M. O'Hara - Pearl River NY

Assignee:

American Cyanamid Company - Madison NJ

International Classification:

C07K 14435
C12N 1512

US Classification:

530350

Abstract:

The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence coding for an amphotropic retrovirus receptor. This receptor is referred to as GLVR2 and has approximately 62% homology with the GLVR1 gene encoding for Gibbon Ape Leukemia Virus (GALV). Differences for the type of retroviruses interacting with the receptors exist. The protein encoding by the GLVR2 gene, cells transformed or transfected by the gene and vectors containing the gene are also disclosed.

US Patent:

62620827, Jul 17, 2001

Filed:

Sep 25, 2000

Appl. No.:

9/669483

Inventors:

Jonathan Bloom - Nyack NY
Martin DiGrandi - Piermont NY
Russell Dushin - Garrison NY
Stanley Lang - Carlsbad CA
Bryan O'Hara - Norwood NJ

International Classification:

C07D40112
A61K 3144

US Classification:

514336

Abstract:

Compounds of the formula ##STR1## wherein R. sub. 1 -R. sub. 5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, --CN, --NO. sub. 2, --CO. sub. 2 R. sub. 6, --COR. sub. 6, --OR. sub. 6, --SR. sub. 6, --SOR. sub. 6, --SO. sub. 2 R. sub. 6, --CONR. sub. 7 R. sub. 8, --NR. sub. 6 N(R. sub. 7 R. sub. 8), --N(R. sub. 7 R. sub. 8) or W--Y--(CH. sub. 2). sub. n --Z; or R. sub. 2 and R. sub. 3 or R. sub. 3 and R. sub. 4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R. sub. 6 and R. sub. 7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R. sub. 8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R. sub. 7 and R. sub.

US Patent:

58520155, Dec 22, 1998

Filed:

Jan 27, 1997

Appl. No.:

8/789038

Inventors:

Yakov Gluzman - late of Upper Saddle River NJ
James P. LaRocque - Highland Mills NY
Bryan M. O'Hara - Pearl River NY
John E. Morin - Cold Spring NY
George A. Ellestad - Pearl River NY
Boris Mitsner - Nanuet NY
Wei-Dong Ding - Nanuet NY
Yuri E. Raifeld - Tarrytown NY
Antonina A. Nikitenko - Tarrytown NY

Assignee:

American Cyanamid Company - Madison NJ

International Classification:

C07D40310
A61K 3153

US Classification:

514245

Abstract:

This invention provides triazine ring containing anionic compounds, pharmaceutical compositions containing these compounds and methods utilizing these compounds for treating viral infections, particularly infections by respiratory syncitial virus, the compounds having the general structure: ##STR1## and the pharmaceutically acceptable salt thereof.