Bryan Leo Roth

US Patent:

6489488, Dec 3, 2002

Filed:

Jan 11, 2002

Appl. No.:

10/042220

Inventors:

Richard A. Glennon - Midlothian VA
Bryan Roth - Moreland Hills OH

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

C07D20956

US Classification:

548439

Abstract:

Compounds which have enhanced affinity and selectivity for 5-HT receptors have been identified. These compounds can be used therapeutically in the treatment of mental disorders via administration in a pharmacologically acceptable delivery route to a patient in need thereof, or can be used to identify antagonists of 5-HT receptors by well known screening methodologies which could themselves be used in the treatment of mental disorders.

US Patent:

6518297, Feb 11, 2003

Filed:

Jan 11, 2002

Appl. No.:

10/042265

Inventors:

Richard A. Glennon - Midlothian VA
Bryan Roth - Moreland Hills OH

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

C07D20904

US Classification:

514415, 548491

Abstract:

Compounds which have enhanced affinity and selectivity for 5-HT receptors have been identified. These compounds can be used therapeutically in the treatment of mental disorders via administration in a pharmacologically acceptable delivery route to a patient in need thereof, or can be used to identify antagonists of 5-HT receptors by well known screening methodologies which could themselves be used in the treatment of mental disorders.

US Patent:

7655691, Feb 2, 2010

Filed:

Sep 27, 2005

Appl. No.:

11/237318

Inventors:

Howard P. Sard - Arlington MA, US
Louis Shuster - Brighton MA, US
Bryan Roth - Moreland Hills OH, US
Cynthia Morency - Andover MA, US
Govindaraj Kumaran - Woburn MA, US
Liang Xu - Woburn MA, US

International Classification:

A61K 31/404
C07F 9/06
C07D 209/14

US Classification:

514415, 548414, 548491

Abstract:

Novel indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.

US Patent:

7687538, Mar 30, 2010

Filed:

Jul 29, 2005

Appl. No.:

11/192925

Inventors:

Jordan Zjawiony - Oxford MS, US
Hesham Fahmy - Brookings SD, US
David Jeremy Stewart - Brevard NC, US
Bryan Roth - Moreland Hills OH, US

Assignee:

University of Mississippi - University MS
Case Western Reserve University - Cleveland OH

International Classification:

A61K 31/35
C07D 493/00

US Classification:

514455, 549280

Abstract:

Compounds and compositions that are salvinorin A and salvinorin B derivatives that demonstrate selectivity and/or potency for the k-opioid receptor (KOR), allowing for their use as medicines, as well as chemical probes (both radiolabeled and cold) for fields utilizing the techniques of radiolabeled binding assays.

US Patent:

8071786, Dec 6, 2011

Filed:

Dec 14, 2009

Appl. No.:

12/637600

Inventors:

Howard P. Sard - Arlington MA, US
Louis Shuster - Brighton MA, US
Bryan Roth - Moreland Hills OH, US
Cynthia Morency - Andover MA, US
Govindaraj Kumaran - Woburn MA, US
Liang Xu - Woburn MA, US

Assignee:

Galenea Corp. - Cambridge MA

International Classification:

C07D 209/14

US Classification:

548506

Abstract:

Novel indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.

US Patent:

8492591, Jul 23, 2013

Filed:

Feb 3, 2011

Appl. No.:

13/576819

Inventors:

Alan Kozikowski - Chicago IL, US
Bryan Roth - Durham NC, US
Andreas Svennebring - Nacka, SE
Sung Jin Cho - Daejeon, KR

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL
The University of North Carolina at Chapel Hikll - Chapel Hill NC

International Classification:

C07C 211/00
C07C 23/00

US Classification:

564455, 564152, 564457

Abstract:

Highly selective 5-HT(2C) receptor agonists receptors are disclosed. The 5-HT(2C) receptor agonists are used in the treatments of disease and conditions wherein modulation of 5-HT(2C) receptors provides a benefit, such as obesity and psychiatric disorders.

US Patent:

20090203750, Aug 13, 2009

Filed:

Aug 24, 2006

Appl. No.:

12/064447

Inventors:

Alan Kozikowski - Chicago IL, US
Toru Kurome - Hyogo, JP
Vincent Setola - Ocean Pines MD, US
Bryan Roth - Durham NC, US

International Classification:

A61K 31/135
A61K 31/4409
C07C 211/17
C07C 211/19
C07D 213/36
A61P 3/00

US Classification:

514357, 514646, 514657, 564305, 564428, 546329

Abstract:

This invention relates to compounds which modulate receptors of the 5-HT2 family of receptors, and particularly to compounds which modulate 5-HT2C receptors. Compounds of the invention include agonists and selective agonists for the 5-HT2C receptor Compounds of the invention include selective agonists for the 5-HT2C receptor which exhibit significantly less or no agonist activity on the 5-HT2A receptor and/or the 5-HT2B receptor. Compounds of this invention are those of Formula I and pharmaceutically acceptable salts, esters and solvates (including hydrates) wherein variables are defined in the specification hereof.

US Patent:

20090318527, Dec 24, 2009

Filed:

Feb 11, 2009

Appl. No.:

12/369659

Inventors:

Howard Sard - Arlington MA, US
Yiliang Zhang - Lowell MA, US
Jie Li - Baltimore MD, US
Louis Shuster - Brookline MA, US
Bryan Roth - Durham NC, US
Niels Jensen - Carrboro NC, US

International Classification:

A61K 31/404
C07D 209/14

US Classification:

514415, 548491

Abstract:

Novel indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.