Candace E Johnson

US Patent:

20050234009, Oct 20, 2005

Filed:

Mar 29, 2005

Appl. No.:

11/093123

Inventors:

Candace Johnson - Amherst NY, US
Donald Trump - Buffalo NY, US

International Classification:

A61K031/7076
A61K031/7072
A61K031/59

US Classification:

514045000, 514049000, 514167000

Abstract:

The present invention relates to a method of inhibiting solid tumor cell or leukemia cell proliferation by first administering to a solid tumor cell or leukemia cell either vitamin D or a derivative thereof and subsequently administering at least one anti-metabolic nucleoside analog to the solid tumor cell or the leukemia cell. Also disclosed is a method of treating a cancerous condition. Methods of down regulating a p-AKt survival signaling pathway and modulating activity of a pro-apoptotic caspases is also disclosed.

US Patent:

20060148752, Jul 6, 2006

Filed:

Feb 28, 2006

Appl. No.:

11/363667

Inventors:

Candace Johnson - Amherst NY, US
Donald Trump - Buffalo NY, US

International Classification:

A61K 31/7072
A61K 31/7076
A61K 31/59

US Classification:

514045000, 514049000, 514167000

Abstract:

The present invention relates to a method of inhibiting solid tumor cell or leukemia cell proliferation by first administering to a solid tumor cell or leukemia cell either vitamin D or a derivative thereof and subsequently administering at least one anti-metabolic nucleoside analog to the solid tumor cell or the leukemia cell. Also disclosed is a method of treating a cancerous condition. Methods of down regulating a p-AKt survival signaling pathway and modulating activity of a pro-apoptotic caspases is also disclosed.

US Patent:

20080003304, Jan 3, 2008

Filed:

Jan 29, 2007

Appl. No.:

11/668330

Inventors:

Candace Johnson - Buffalo NY, US
Donald Trump - Pittsburgh PA, US

Assignee:

University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61K 31/59
A61K 33/24
A61P 35/00

US Classification:

424649000, 514167000

Abstract:

This invention relates to combination chemotherapy, particularly involving vitamin D or a derivative thereof hi one aspect, the invention provides a method of killing a cell by first administering to the cell vitamin D (or a derivative) and subsequently administering to the cell a cytotoxic agent. Where this strategy is applied to an intact tumor, the present invention provides a method of retarding the growth of the tumor by first administering vitamin D (or a derivative) to the tumor and subsequently administering the cytotoxic agent. A further aspect of the invention concerns a method of treating prostate cancer within a patient by co-administration of vitamin D (or a derivative) and a glucocorticoid to the patient. In yet a further aspect, the invention provides an improved method of treating a patient with vitamin-D involving the adjunctive administration of zoledronate.