Cara Carthel Burns

US Patent:

7776521, Aug 17, 2010

Filed:

May 14, 2007

Appl. No.:

11/748359

Inventors:

Paul A. Rota - Decatur GA, US
Larry J. Anderson - Atlanta GA, US
William J. Bellini - Lilburn GA, US
Michael D. Bowen - Decatur GA, US
Cara Carthel Burns - Avondale Estates GA, US
Raymond Campagnoli - Decatur GA, US
Qi Chen - Marietta GA, US
James A. Comer - Decatur GA, US
Byron T. Cook - Augusta GA, US
Shannon L. Emery - Lusaka, ZM
Dean D. Erdman - Decatur GA, US
Cynthia S. Goldsmith - Lilburn GA, US
Jeanette Guarner - Decatur GA, US
Charles D. Humphrey - Lilburn GA, US
Joseph P. Icenogle - Atlanta GA, US
Thomas G. Ksiazek - Lilburn GA, US
Richard F. Meyer - Roswell GA, US
Stephan S. Monroe - Decatur GA, US
William Allan Nix - Bethlehem GA, US
M. Steven Oberste - Lilburn GA, US
Christopher D. Paddock - Atlanta GA, US
Teresa C. T. Peret - Atlanta GA, US
Pierre E. Rollin - Lilburn GA, US
Mark A. Pallansch - Lilburn GA, US
Anthony Sanchez - Lilburn GA, US
Wun-Ju Shieh - Norcross GA, US
Suxiang Tong - Alpharetta GA, US
Sherif R. Zaki - Atlanta GA, US

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention - Washington DC

International Classification:

C12Q 1/70
C07H 21/00
C12N 15/50

US Classification:

435 5, 536 2432, 536 2433

Abstract:

Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames, as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.

US Patent:

20080118530, May 22, 2008

Filed:

Oct 7, 2005

Appl. No.:

11/576941

Inventors:

Olen M. Kew - Alpharetta GA, US
Cara C. Burns - Avondale Estates GA, US
Jing Shaw - Decatur GA, US
Raymond Campagnoli - Decatur GA, US
Jacqueline Quay - Chapel Hill NC, US

International Classification:

A61K 39/00
C12N 15/00
A61K 39/12
A61K 39/02
A61P 37/00
A61K 39/002
C12N 15/74

US Classification:

4242071, 435440, 435471, 4241841, 4242041, 4242341, 4242691, 4242741, 4242211, 4242291, 4242191

Abstract:

Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.

US Patent:

7220852, May 22, 2007

Filed:

Apr 12, 2004

Appl. No.:

10/822904

Inventors:

Paul A. Rota - Decatur GA, US
Larry J. Anderson - Atlanta GA, US
William J. Bellini - Lilburn GA, US
Cara Carthel Burns - Avondale Estates GA, US
Raymond Campagnoli - Decatur GA, US
Qi Chen - Marietta GA, US
James A. Comer - Decatur GA, US
Shannon L. Emery - Lusaka, ZM
Dean D. Erdman - Decatur GA, US
Cynthia S. Goldsmith - Lilburn GA, US
Charles D. Humphrey - Lilburn GA, US
Joseph P. Icenogle - Atlanta GA, US
Thomas G. Ksiazek - Lilburn GA, US
Stephan S. Monroe - Decatur GA, US
William Allan Nix - Bethlehem GA, US
M. Steven Oberste - Lilburn GA, US
Teresa C. T. Peret - Atlanta GA, US
Pierre E. Rollin - Lilburn GA, US
Mark A. Pallansch - Lilburn GA, US
Anthony Sanchez - Lilburn GA, US
Suxiang Tong - Alpharetta GA, US
Sherif R. Zaki - Atlanta GA, US

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention - Washington DC

International Classification:

C12N 15/50
C12N 7/00

US Classification:

536 2372, 4352351

Abstract:

Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames, as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.

US Patent:

20200268865, Aug 27, 2020

Filed:

May 13, 2020

Appl. No.:

15/931336

Inventors:

- Atlanta GA, US
Cara Carthel Burns - Avondale Estates GA, US
Jing Shaw - Decatur GA, US
Raymond Campagnoli - Decatur GA, US
Jacqueline Quay - Chapel Hill NC, US

Assignee:

The Government of the USA as represented by the Secretary of the Dept. of Health and Human Services - Atlanta GA

International Classification:

A61K 39/108
A61K 39/00
C07K 14/245
C12N 15/67
C12N 7/00

Abstract:

Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.

US Patent:

20180264098, Sep 20, 2018

Filed:

May 31, 2018

Appl. No.:

15/994074

Inventors:

- Atlanta GA, US
Cara Carthel Burns - Avondale Estates GA, US
Jing Shaw - Decatur GA, US
Raymond Campagnoli - Decatur GA, US
Jacqueline Quay - Chapel Hill NC, US

Assignee:

The Government of the USA as represented by the Secretary of the Dept. of Health and Human Service - Atlanta GA

International Classification:

A61K 39/108

Abstract:

Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.

US Patent:

20170354727, Dec 14, 2017

Filed:

Aug 23, 2017

Appl. No.:

15/684355

Inventors:

- Atlanta GA, US
Cara Carthel Burns - Avondale Estates GA, US
Jing Shaw - Decatur GA, US
Raymond Campagnoli - Decatur GA, US
Jacqueline Quay - Chapel Hill NC, US

International Classification:

A61K 39/108
C12N 15/67
C12N 7/00
A61K 39/00
C07K 14/245

Abstract:

Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.

US Patent:

20140356390, Dec 4, 2014

Filed:

Aug 20, 2014

Appl. No.:

14/464619

Inventors:

- Atlanta GA, US
Cara Carthel Burns - Avondale Estates GA, US
Jing Shaw - Decatur GA, US
Raymond Campagnoli - Decatur GA, US
Jacqueline Quay - Chapel Hill NC, US

International Classification:

A61K 39/108
C12N 15/67

US Classification:

4241901, 435471, 4352523

Abstract:

Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.