Carl P Ciosek

US Patent:

47074949, Nov 17, 1987

Filed:

Aug 26, 1986

Appl. No.:

6/900564

Inventors:

Ravi K. Varma - Belle Mead NJ
Carl P. Ciosek - New Hope PA
Eric M. Gordon - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 31557
C07D30700

US Classification:

514469

Abstract:

7-Oxabicyclo(2. 2. 1)heptane analogs are disclosed having the general formula ##STR1## wherein R. sub. 1 is lower alkyl, alkenyl, substituted alkenyl or alkynyl; R. sub. 2 is lower alkyl, alkenyl or alkynyl; A is --CH. sub. 2 --CH. dbd. CH-- or a single bond; X is --CH. sub. 2, --CH(CH. sub. 3) or --C(CH. sub. 3). sub. 2 ; n is an integer from 0 to 9, with the proviso that when A is a single bond, n is an integer from 1 to 9; including all stereoisomers. These new compounds have been found to be inhibitors of arachidonic acid cyclooxygenase and are therefore useful as antiinflammatory antipyretic and analgesic agents.