The invention provides a method of inducing a protective response in cells by activating a heat shock response, via heat shock transcription factor (HSF), without stressing the cells. The invention is based on the surprising discovery that HSF can be activated in non-stressed cells by disrupting interaction with the repressive cognate protein, Hsc70. As described herein, non-steroidal anti-inflammatory drugs (NSAID), including salicylic acid and ibuprofen, can stimulate HSF DNA binding, Hsp70 transcription and Hsp70 protein synthesis in non-stressed cells. By activating HSF, the degenerative effects of certain neurodegenerative proteins such as polyglutamine repeat proteins (Huntington's disease) and the α-synuclein protein (Parkinson's disease) can be offset. The invention thus provides a method of ameliorating symptoms of neurodegenerative disease.
Name / Title
Company / Classification
Phones & Addresses
Carl Parker CTO
Pride Foundation Inc Individual and Family Social Services
1122 E Pike St # 1001, Seattle, WA 98122
Carl Parker CEO
Nutritional Sounds Construction Materials
7218 Sw 257Th Ct. - 7218 Sw 257Th Ct, North Bend, WA 98068
Carl Parker CTO
Pride Foundation Inc Noncommercial Research Organization · Human Rights Organizations · Research and Development in the Social Sciences and Humaniti · Other Individual and Family Services
1122 E Pike St, Seattle, WA 98122 2063233318, 2063231017
Carl Parker Treasurer
Marriage Fulfillment - Presbyterian Expression, Inc
8221 Westchester Dr, Vienna, VA 22182 2611 S 288 St, Auburn, WA 98003 52 NE Is Dr NE, Northeast, MD 21901 14152 Choco Rd, Apple Valley, CA 92307
ETERNITY PRODUCTIONS Eternity Noun: Infinite or unending time. A state to which time has no application; timelessness Eternity Productions is a graphics company in which we work hard to give you the ...
"This next system is really going to be a very significant storm for a lot of the country," said Carl Parker, a meteorologist for The Weather Channel. "It's going to grab up plenty of moisture off the Atlantic, throw it back and into the Northeast."
Date: Dec 13, 2013
Category: U.S.
Source: Google
The Weather Channel 's Hurricane Sandy Coverage Garners the Network's ...
everything! Their hype of Isaac and then general neglect of reporting about the real after-effects was profane. Likewise last year with Irene. Oh well New York City or New Orleans didnt get wiped off the map, lets head home to Atlanta with Carl Parker and Alexandra whats-er-face in the studio.