Carl G Reppucci

US Patent:

20140073570, Mar 13, 2014

Filed:

Sep 11, 2013

Appl. No.:

14/024230

Inventors:

- Exeter, DE
Carl REPPUCCI - North Andover MA, US

International Classification:

A61K 9/00
A61K 47/22
A61K 9/107
A61K 38/08

US Classification:

514 113

Abstract:

Disclosed are compositions and methods for treating a patient with a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins, wherein the pharmaceutical composition is in the form of an emulsified nasal spray comprising: a macrocyclic permeation enhancer, a liquid carrier comprising water, and a therapeutically effective amount of a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins; wherein the macrocyclic permeation enhancer is a Hsieh enhancer emulsified in the liquid carrier.

US Patent:

20160199296, Jul 14, 2016

Filed:

Mar 24, 2016

Appl. No.:

15/079576

Inventors:

- Wilmington, DE
Carl Reppucci - North Andover MA, US
Zhengmao Li - New Market NH, US

International Classification:

A61K 9/00
A61K 31/365
A61K 31/5513

Abstract:

The present invention provides pharmaceutical compositions for intranasal delivery of a benzodiazepine. The composition may contain a therapeutically effective amount of a benzodiazepine or a pharmaceutically acceptable salt thereof, and a permeation enhancer. The permeation enhancer may be propylene glycol or a Hsieh permeation enhancer. The present compositions have excellent bioavailability. After administration of the present compositions, therapeutically effective plasma levels of the benzodiazepine may be achieved rapidly. The present pharmaceutical composition may be used to treat a patient suffering from anxiety, epilepsy, insomnia, agitation, seizures, muscular disorders, alcohol dependence, and drug withdrawal.