Carl D Wright

US Patent:

6825921, Nov 30, 2004

Filed:

Nov 10, 2000

Appl. No.:

09/710061

Inventors:

Douglas N. Modlin - Palo Alto CA
John C. Owicki - Palo Alto CA
Jon F. Petersen - Redwood City CA
Todd E. French - Cupertino CA
Carl L. Wright - Kilauea HI
Jeanne A. Ruiz - Sunnyvale CA
Lorne E. Bechtel - Los Altos CA

Assignee:

Molecular Devices Corporation - Sunnyvale CA

International Classification:

G01N 2100

US Classification:

356 73, 235454

Abstract:

Apparatus and methods for combining multiple modes and methods of optical detection, postprocessing, and/or feedback loops in bioanalytical measurements. The methods may include (1) positioning a composition at an examination site in a multi-mode instrument; (2) detecting light transmitted form the composition using the multi-mode instrument in a first optical measurement mode; (3) detecting light transmitted from the composition using the multi-mode instrument in a second optical measurement mode, the second mode being different than the first mode; and (4) computing a quantity related to a property of the composition using the light detected in at least one of the optical measurement modes. These steps may be performed on one or more samples, simultaneously and/or sequentially. The quantity may relate to photoluminescence, chemiluminescence, absorption, and/or scattering, among others.