Carlos M Morales

US Patent:

8110144, Feb 7, 2012

Filed:

Sep 17, 2004

Appl. No.:

10/944635

Inventors:

Carlos R. Morales - Cumming GA, US

Assignee:

Chemence Medical, Inc. - Alpharetta GA

International Classification:

A61L 2/00
G01N 31/00

US Classification:

422 1, 436 1

Abstract:

Disclosed are processes for sterilization of cyanoacrylate adhesive compositions, the compositions, comprising 2-cyanoacrylate ester monomers, so produced and a method for assaying the effectiveness of the sterilization process. The process comprises heating the adhesive composition to from about 70 C. to about 140 C. for an effective amount of time. The effectiveness of the process can be assayed by disposing bacterial spores in the cyanoacrylate monomer, exposing the composition to a dry heat sterilization process, transferring the cyanoacrylate composition to a sterile aldose solution, transferring and exposing the sample to a nutrient medium which supports germination and growth of viable spores, incubating the samples, and determining the presence or absence of growth.

US Patent:

20070248486, Oct 25, 2007

Filed:

Apr 24, 2006

Appl. No.:

11/379994

Inventors:

Carlos Morales - Cumming GA, US

Assignee:

CLAST TRADING LTD - Hong Kong

International Classification:

A61K 31/785
A61L 2/00

US Classification:

422022000, 424078270

Abstract:

The present invention provides a novel method of sterilizing 2-Cyanoacrylate ester compositions using a combination of chemical and irradiation means, and the resulting novel compositions. The combination of monomeric 2-Cyanoacrylate and irradiation have a lethal effect on microbials, rendering sterilized compositions when the appropriate sterilization condition is achieved and when the method is applied to 2-Cyanoacrylates in sealed containers. Samples are sterilized using electron beam at doses as low as about 1 to about 5 Kgy.

US Patent:

20080311323, Dec 18, 2008

Filed:

Jun 12, 2007

Appl. No.:

11/762018

Inventors:

Carlos R. Morales - Cumming GA, US

Assignee:

CHEMENCE, INC. - Alpharetta GA

International Classification:

B65D 85/00
A61L 2/04

US Classification:

428 357, 422 1

Abstract:

Disclosed are processes for sterilization of cyanoacrylate adhesive compositions; the compositions, comprising 2-cyanoacrylate ester monomers, so produced and a method for assaying the effectiveness of the sterilization process. A typical process comprises heating the adhesive composition to from about 70 C. to about 140 C. for an effective amount of time. The effectiveness of a process can be assayed by disposing bacterial spores in the cyanoacrylate monomer, exposing the composition to a dry heat sterilization process, transferring the cyanoacrylate composition to a sterile aldose solution, transferring and exposing the sample to a nutrient medium which supports germination and growth of viable spores, incubating the samples, and determining the presence or absence of growth.

US Patent:

20100213096, Aug 26, 2010

Filed:

Dec 8, 2009

Appl. No.:

12/633795

Inventors:

Carlos R. Morales - Cumming GA, US

Assignee:

CLAST TRADING LIMITED - Hong Kong

International Classification:

B65D 85/00
A61L 2/04

US Classification:

2065241, 422 22

Abstract:

The viscosity of 2-cyanoacrylate monomer based adhesives is increased by combining the monomers with suitable thickeners according to a certain process. The resulting formulations may be heat sterilized without degrading the viscosity or causing premature polymerization. The effectiveness of the sterilization process is assayed by disposing bacterial spores in the formulation, exposing it to a dry heat sterilization process, transferring it to a sterile aldose solution, transferring and exposing the sample to a nutrient medium which supports germination and growth of viable spores, incubating the samples, and determining the presence or absence of growth.

US Patent:

20120128903, May 24, 2012

Filed:

Jan 26, 2012

Appl. No.:

13/358690

Inventors:

Carlos R. Morales - Cumming GA, US

Assignee:

CHEMENCE MEDICAL, INC. - Alpharetta GA

International Classification:

B32B 1/02
A61L 2/04
C09J 135/04

US Classification:

428 344, 524533, 422 22, 428 341, 428 357

Abstract:

Adhesive 2-cyanoacrylate compositions are adjusted to a preferred initial viscosity of 400 to 600 centipoises by the addition of polycyanoacrylate thickeners, and are sterilized in a preferred method by heating them at a temperature of no greater than about 110 C. for no more than about 120 minutes. Articles of manufacture are vials or squeezable tubes made of compatible glass, aluminum, or plastic.

US Patent:

20130011589, Jan 10, 2013

Filed:

Sep 14, 2012

Appl. No.:

13/616947

Inventors:

Carlos R. Morales - Cumming GA, US

Assignee:

CHEMENCE MEDICAL, INC. - Alpharetta GA

International Classification:

C09J 133/14

US Classification:

428 344, 524555, 428 357

Abstract:

The viscosities of 2-cyanoacrylate adhesive compositions are adjusted by the addition of polymeric thickeners to a preferred initial viscosity that will not increase significantly when sterilized by heating them at a temperature of no greater than about 110 C. for no more than about 120 minutes. Articles of manufacture are vials or squeezable tubes containing these compositions.