Carmen M Alvarez

US Patent:

6372747, Apr 16, 2002

Filed:

Dec 16, 1999

Appl. No.:

09/465553

Inventors:

Arthur G. Taveras - Denville NJ
Ronald J. Doll - Maplewood NJ
Alan B. Cooper - West Caldwell NJ
Johan A. Ferreira - Bensalem PA
Timothy Guzi - Chatham NJ
Dinanath F. Rane - Morganville NJ
Viyyoor M. Girijavallabhan - Parsippany NJ
Cynthia J. Aki - Rutherford NJ
Jianping Chao - Summit NJ
Carmen Alvarez - Roselle Park NJ
Joseph M. Kelly - Parlin NJ
Tarik Lalwani - Philadelphia PA
Jagdish A. Desai - Spotswood NJ
James J-S Wang - Westfield NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31496

US Classification:

51425303, 51425405, 51425501, 514252, 514290, 514326, 544361, 544370, 546 93, 546210

Abstract:

Disclosed are compounds of the formula: wherein R represents an imidazole ring; R represents a carbamate, urea, amide or sulfonamide group; R represents H when the alkyl chain between the amide group and the R imidazole group is substituted, or R represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R is H, and the alkyl chain between the amide group and the R imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

US Patent:

6387905, May 14, 2002

Filed:

Mar 1, 2001

Appl. No.:

09/797081

Inventors:

F George Njoroge - Union NJ
Arthur G. Taveras - Rockaway NJ
Ronald J. Doll - Maplewood NJ
Tarik Lalwani - Edison NJ
Carmen Alvarez - Roselle Park NJ
Stacy W. Remiszewski - Washington Township NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31496

US Classification:

51425303, 514290, 544361, 546 93

Abstract:

Novel compounds of the formula: are disclosed. Compounds of Formula 1. 0 are represented by the compounds of formulas: wherein R , R and R are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.

US Patent:

6410541, Jun 25, 2002

Filed:

Jan 24, 2001

Appl. No.:

09/768918

Inventors:

Stacy W. Remiszewski - Washington Township NJ
Ronald J. Doll - Maplewood NJ
Carmen Alvarez - Roselle Park NJ
Tarik Lalwani - Edison NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31496

US Classification:

51425303, 514290, 544361, 546 93

Abstract:

Novel compounds of the formula: are disclosed. In Formula 1. 0 a represents N or NO, R and R are halo, R and R are independently H or halo provided that at least one is H, X is C, CH or N, and R represents a cycloalkyl or a heterocycloalkyl ring that is substitued. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.

US Patent:

6440974, Aug 27, 2002

Filed:

Feb 20, 2001

Appl. No.:

09/788947

Inventors:

Ronald J. Doll - Maplewood NJ
Carmen Alvarez - Roselle Park NJ
Tarik Lalwani - Edison NJ
Yi-Tsung Liu - Morris Township NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31496

US Classification:

51425303, 544361, 544 59, 544121, 5142328, 5142282

Abstract:

Novel compounds of the formula: are disclosed. In Formula 1. 0 a represents N or NO, R and R are halo, R and R are independently H or halo provided that at least one is H, X is C, CH or N, and T represents a five or six membered heterocycloalkyl ring having one or two heteroatoms selected from S or O. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.

US Patent:

6740661, May 25, 2004

Filed:

Dec 20, 2001

Appl. No.:

10/026999

Inventors:

Arthur G. Taveras - Denville NJ
Ronald J. Doll - Maplewood NJ
Alan B. Cooper - West Caldwell NJ
Johan A. Ferreira - Bensalem PA
Timothy Guzi - Chatham NJ
Alan K. Mallams - Hackettstown NJ
Dinanath F. Rane - Morganville NJ
Viyyoor M. Girijavallabhan - Parsippany NJ
Adriano Afonso - West Caldwell NJ
Cynthia J. Aki - Rutherford NJ
Jianping Chao - Summit NJ
Carmen Alvarez - Roselle Park NJ
Joseph M. Kelly - Parlin NJ
Tarik Lalwani - Philadelphia PA
Jagdish A. Desai - Spotswood NJ
James J-S Wang - Westfield NJ
Jay Weinstein - Upper Montclair NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314545

US Classification:

514290, 514326, 51425501, 51425211, 51425303, 51425405, 514256, 546 93, 546210, 544361, 544370, 544333, 544357

Abstract:

Disclosed are compounds of the formula: wherein R represents an imidazole ring; R represents a carbamate, urea, amide or sulfonamide group; R represents H when the alkyl chain between the amide group and the R imidazole group is substituted, or R represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R is H, and the alkyl chain between the amide group and the R imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

US Patent:

7067661, Jun 27, 2006

Filed:

Sep 3, 2003

Appl. No.:

10/653776

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Carmen S. Alvarez - Livingston NJ, US
Tin-Yau Chan - Edison NJ, US
Chad Knutson - Garwood NJ, US
Vincent Madison - Mountain Lakes NJ, US
Thierry O. Fischmann - Scotch Plains NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley CA, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bristol PA, US
Haengsoon Park - Plainsboro NJ, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia Drug Discovery, Inc. - Crambury NJ

International Classification:

C07D 487/04

US Classification:

544281

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

7119200, Oct 10, 2006

Filed:

Feb 11, 2004

Appl. No.:

10/776988

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Alan Mallams - Hackettstown NJ, US
Carmen S. Alvarez - Livingston NJ, US
Kartik M. Keertikar - East Windsor NJ, US
Jocelyn Rivera - Monmouth Junction NJ, US
Tin-Yau Chan - Edison NJ, US
Vincent Madison - Mountain Lakes NJ, US
Thierry O. Fischmann - Scotch Plains NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley CA, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bristol PA, US
Haengsoon Park - Plainsboro NJ, US
Vidyadhar M. Hobbs - Somerville NJ, US
Douglas Walsh Hobbs - Yardley PA, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia Drug Discovery, Inc. - Cranbury NJ

International Classification:

C07D 487/04

US Classification:

544281

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

7161003, Jan 9, 2007

Filed:

Sep 3, 2003

Appl. No.:

10/654546

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Alan Mallams - Hackettstown NJ, US
Carmen S. Alvarez - Livingston NJ, US
Kartik M. Keertikar - East Windsor NJ, US
Jocelyn Rivera - Monmouth Junction NJ, US
Tin-Yau Chan - Edison NJ, US
Vincent Madison - Mountain Lakes NJ, US
Thierry O. Fischmann - Scotch Plains NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley NJ, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bristol PA, US
Haengsoon Park - Plainsboro NJ, US
Vidyadhar M. Paradkar - Somerville NJ, US
Douglas Walsh Hobbs - Yardley PA, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia Drug Discovery, Inc. - Cranbury NJ

International Classification:

C07D 487/04

US Classification:

544281

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

Address:

9468 NW 54 Doral Cir Ln, Doral, FL 33178

Phone:

3057169955

VIN:

WAUDF78EX7A115196

Make:

AUDI

Model:

A4

Year:

2007