Carol A Nacy

US Patent:

59194596, Jul 6, 1999

Filed:

Jun 6, 1995

Appl. No.:

8/467101

Inventors:

Carol A. Nacy - Bethesda MD
John W. Holaday - Bethesda MD

Assignee:

EntreMed, Inc. - Rockville MD

International Classification:

A61K 3900
A61K 4500
A61K 39385
A61K 4505

US Classification:

4241921

Abstract:

The present invention encompasses methods for reducing or inhibiting growth factor in cancer cells and tissues. More particularly immunogenic growth factor-containing compositions are administered to a human or animal with a cancer or tumor. The immunogenic compositions elicit the production of antibodies specific for growth factor which reduce the level of circulating growth factor, thus reducing or eliminating the proliferation of cancer. The present invention encompasses growth factor-containing liposomes and vesicles having portions of growth factor externally presented on their surfaces. The present invention also includes antibodies specific for growth factor. Thus, according to the present invention, growth factor levels are reduced either by active immunization of an individual using immunogenic growth factor-containing compositions or by passive immunization via administering to the individual an antibody or a group of antibodies specific for growth factor.