Carol Ann Toth

US Patent:

6949251, Sep 27, 2005

Filed:

Sep 21, 2001

Appl. No.:

09/960789

Inventors:

Paresh S. Dalal - Shrewsbury MA, US
Godofredo R. Dimaano - Edison NJ, US
Carol Ann Toth - Sharon MA, US
Shailesh C. Kulkarni - Natick MA, US

Assignee:

Stryker Corporation - Kalamazoo MI

International Classification:

A61F002/00
C12N011/14
C07K017/14

US Classification:

424423, 424426, 435176, 530811

Abstract:

A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and inducing bone formation are also provided.

US Patent:

7357941, Apr 15, 2008

Filed:

Mar 29, 2005

Appl. No.:

11/093429

Inventors:

Paresh S Dalal - Shrewsbury MA, US
Godofredo R Dimaano - Edison NJ, US
Carol A Toth - Sharon MA, US
Shailesh C Kulkarni - Natick MA, US

Assignee:

Stryker Corporation - Kalamazoo MI

International Classification:

A61F 2/00
C12N 11/14
C07K 17/14
A01N 37/18
A61K 31/7088

US Classification:

424423, 424426, 435176, 514 2, 514 44, 530811

Abstract:

A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and inducing bone formation are also provided.

US Patent:

7390498, Jun 24, 2008

Filed:

Mar 29, 2005

Appl. No.:

11/093818

Inventors:

Paresh S Dalal - Shrewsbury MA, US
Godofredo R Dimaano - Edison NJ, US
Carol A Toth - Sharon MA, US
Shailesh C Kulkarni - Natick MA, US

Assignee:

Stryker Corporation - Kalamazoo MI

International Classification:

A61F 2/00
C12N 11/14
C07K 17/14

US Classification:

424423, 424426, 435176, 530811

Abstract:

A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and inducing bone formation are also provided.

US Patent:

20030049328, Mar 13, 2003

Filed:

Mar 2, 2001

Appl. No.:

09/798518

Inventors:

Paresh Dalal - Shrewsbury MA, US
Godofredo Dimaano - Edison NJ, US
Carol Toth - Sharon MA, US
Shailesh Kulkarni - Natick MA, US

International Classification:

A61K009/14
A61K033/42

US Classification:

424/602000

Abstract:

A porous -tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 m, preferably 50-125 m. The porous -TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. The invention provides a kit and an implant device comprising the porous -TCP, and one or more additional components including a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous -TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous -TCP material and inducing bone formation are also provided.

US Patent:

20070196342, Aug 23, 2007

Filed:

Dec 13, 2006

Appl. No.:

11/638087

Inventors:

Khalid Sadozai - Shrewsbury MA, US
Carol Toth - Webster NY, US

International Classification:

A61K 35/12
A61K 38/18
A61K 31/728
A61K 9/70

US Classification:

424093700, 514012000, 514054000, 424443000, 536053000

Abstract:

A composite for treating an articular defect includes a hyaluronic acid derivative; and at least one member of the group consisting of a cell, a cellular growth factor and a cellular differentiation factor, which is impregnated in, or coupled to, the hyaluronic acid derivative. In one embodiment, carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N-acylurea or O-acyl isourea, or both N-acylurea and O-acyl isourea. In another embodiment, the hyaluronic acid derivative is prepared by reacting an uncrosslinked hyaluronic acid with a biscarbodimide in the presence of a pH buffer in a range of between about 4 and about 8. The composite can be used for regenerating or stimulating regeneration of meniscal tissues in a subject in need thereof.

US Patent:

20090110743, Apr 30, 2009

Filed:

Feb 21, 2008

Appl. No.:

12/072105

Inventors:

Paresh S. Dalal - Shrewsbury MA, US
Godofredo R. Diamaano - Edison NJ, US
Carol Ann Toth - Sharon MA, US
Shailesh C. Kulkarni - Natick MA, US

International Classification:

A61K 9/50
A61P 19/00

US Classification:

424499

Abstract:

A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and inducing bone formation are also provided.