Cary Hsu

US Patent:

20080050341, Feb 28, 2008

Filed:

Oct 7, 2005

Appl. No.:

11/576621

Inventors:

Richard Morgan - Columbia MD, US
Steven Rosenberg - Potomac MD, US
Cary Hsu - Washington DC, US

Assignee:

GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH - Rockville MD

International Classification:

A61K 48/00
A61P 35/00
C12N 5/10

US Classification:

424093200, 435372300

Abstract:

The invention provides for compositions, e.g., pharmaceutical compositions, comprising a T lymphocyte, or a population thereof, expressing at least one recombinant polynucleotide encoding a cytokine that enhances T lymphocyte survival during the contraction phase of an immune response. The invention further provides an isolated T lymphocyte, or population thereof, expressing at least one recombinant polynucleotide encoding the cytokine, wherein the polynucleotide comprises a non-native coding sequence encoding the cytokine. Also provided is the use of such compositions and T lymphocytes, or populations thereof, for the treatment or prevention of a medical condition e.g., cancer. A method of preparing the a T lymphocyte with enhanced T cell survival is further provided herein.