Catherine S Greer

US Patent:

6767699, Jul 27, 2004

Filed:

May 31, 2001

Appl. No.:

09/872086

Inventors:

John M. Polo - Hayward CA
Catherine Greer - Oakland CA

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

C12Q 170

US Classification:

435 5, 435 4, 4353201, 435 34, 4351739, 4242181

Abstract:

Methods of production and purification for viruses and virus-derived vectors, including those related to alphaviruses, are disclosed. In one aspect, methods of purification that subject alphavirus replicon particle preparations to one or more steps of chromatographic purification, such as using an ion exchange resin, are provided. Also disclosed are methods of characterizing alphavirus replicon particles and utilizing these materials for vaccines and gene-based therapeutics.

US Patent:

20050112752, May 26, 2005

Filed:

Jun 29, 2004

Appl. No.:

10/881575

Inventors:

John Polo - Hayward CA, US
Catherine Greer - Oakland CA, US
Daniel De La Vega - San Diego CA, US
Thomas Dubensky - Piedmont CA, US

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

C12Q001/70
C12N015/86
C12N007/02

US Classification:

435239000, 435456000

Abstract:

Methods of production and purification for viruses and virus-derived vectors, including those related to alphaviruses, are disclosed. In one aspect, methods of purification that subject alphavirus replicon particle preparations to one or more steps of chromatographic purification, such as using an ion exchange resin, are provided. Also disclosed are methods of characterizing alphavirus replicon particles and utilizing these materials for vaccines and gene-based therapeutics.

US Patent:

20090104226, Apr 23, 2009

Filed:

May 20, 2005

Appl. No.:

11/597347

Inventors:

Silvia Perri - Castro Valley CA, US
John Polo - Danville CA, US
Yasushi Uematsu - Siena, IT
Catherine Greer - Oakland CA, US

Assignee:

NOVARTIS VACCINES AND DIAGNOSTICS INC. - Emeryville CA

International Classification:

A61K 39/00

US Classification:

4242011, 4242061, 4242041, 4242021

Abstract:

Described herein are compositions and methods for stimulating an immune response to one or more proteins derived from one or more respiratory pathogens. In particular, the invention relates to alphavirus replicons, alphavirus vector constructs, alphavirus replicon particles expressing one or more antigens derived from one or more respiratory pathogens as well as to method of making and using these immunogenic compositions.

US Patent:

20100055128, Mar 4, 2010

Filed:

Sep 18, 2008

Appl. No.:

12/212978

Inventors:

John M. Polo - Hayward CA, US
Catherine Greer - Oakland CA, US
Daniel De La Vega, JR. - San Diego CA, US

Assignee:

Novartis Vaccines and Diagnostics Inc - Emeryville CA

International Classification:

A61K 39/12
C12N 7/02

US Classification:

4242041, 435239

Abstract:

Methods of production and purification for viruses and virus-derived vectors, including those related to alphaviruses, are disclosed. in one aspect, methods of purification that subject alphavirus replicon particle preparations to one or more steps of chromatographic purification, such as using an ion exchange resin, are provided. Also disclosed are methods of characterizing alphavirus replicon particles and utilizing these materials for vaccines and gene-based therapeutics.

US Patent:

20110002958, Jan 6, 2011

Filed:

Jun 1, 2010

Appl. No.:

12/791140

Inventors:

Silvia Perri - Castro Valley CA, US
John Polo - Danville CA, US
Yasushi Uematsu - Siena, IT
Catherine Greer - Oakland CA, US

Assignee:

NOVARTIS VACCINES AND DIAGNOSTICS, INC. - Emeryville CA

International Classification:

A61K 39/215
A61P 31/14
A61P 31/16
A61P 31/04

US Classification:

4241991

Abstract:

Described herein are compositions and methods for stimulating an immune response to one or more proteins derived from one or more respiratory pathogens. In particular, the invention relates to alphavirus replicons, alphavirus vector constructs, and alphavirus replicon particles expressing one or more antigens derived from one or more respiratory pathogens, as well as to methods of making and using the immunogenic compositions.

US Patent:

20120231526, Sep 13, 2012

Filed:

Mar 27, 2012

Appl. No.:

13/430920

Inventors:

John M. Polo - Hayward CA, US
Catherine Greer - Oakland CA, US
Daniel De La Vega, JR. - San Diego CA, US

International Classification:

C12N 7/02

US Classification:

435239

Abstract:

Methods of production and purification for viruses and virus-derived vectors, including those related to alphaviruses, are disclosed. In one aspect, methods of purification that subject alphavirus replicon particle preparations to one or more steps of chromatographic purification, such as using an ion exchange resin, are provided. Also disclosed are methods of characterizing alphavirus replicon particles and utilizing these materials for vaccines and gene-based therapeutics