Catherine Odom Greer

US Patent:

6602705, Aug 5, 2003

Filed:

Dec 30, 1999

Appl. No.:

09/475515

Inventors:

Susan W. Barnett - San Francisco CA
Jan zur Megede - San Francisco CA
Catherine Greer - Oakland CA
Mark Selby - San Francisco CA

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

C12N 1500

US Classification:

4353201, 536 231, 536 2372, 4241841, 4241851, 4241871, 4241881, 4242071

Abstract:

The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.

US Patent:

6767699, Jul 27, 2004

Filed:

May 31, 2001

Appl. No.:

09/872086

Inventors:

John M. Polo - Hayward CA
Catherine Greer - Oakland CA

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

C12Q 170

US Classification:

435 5, 435 4, 4353201, 435 34, 4351739, 4242181

Abstract:

Methods of production and purification for viruses and virus-derived vectors, including those related to alphaviruses, are disclosed. In one aspect, methods of purification that subject alphavirus replicon particle preparations to one or more steps of chromatographic purification, such as using an ion exchange resin, are provided. Also disclosed are methods of characterizing alphavirus replicon particles and utilizing these materials for vaccines and gene-based therapeutics.

US Patent:

7112330, Sep 26, 2006

Filed:

Aug 13, 1999

Appl. No.:

09/762762

Inventors:

Daniela Tornese Buonamassa - Siena, IT
Catherine E. Greer - Oakland CA, US
Cesira L. Galeotti - Montegriggioni, IT
Giuliano Bensi - Firenze, IT
Roberto Petracca - Siena, IT

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

A61K 39/12

US Classification:

4242041, 435 691, 4352351

Abstract:

Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLPs induced the production conformational antibodies against both L1 proteins upon administration to mice.

US Patent:

7494787, Feb 24, 2009

Filed:

Apr 13, 2006

Appl. No.:

11/404063

Inventors:

Daniela Tornese Buonamassa - Siena, IT
Catherine E. Greer - Oakland CA, US
Cesira L. Galeotti - Montegriggioni, IT
Giuliano Bensi - Florence, IT
Roberto Petracca - Siena, IT

Assignee:

Novartis Vaccines and Diagnostics, Inc. - Emeryville CA

International Classification:

C12P 21/06

US Classification:

435 691, 4353201

Abstract:

Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLPs induced the production of conformational antibodies against both L1 proteins upon administration to mice.

US Patent:

7718401, May 18, 2010

Filed:

Feb 6, 2008

Appl. No.:

12/026619

Inventors:

Susan W. Barnett - San Francisco CA, US
Jan zur Megede - San Francisco CA, US
Indresh Srivastava - Concord CA, US
Ying Lian - Vallejo CA, US
Karin Hartog - Piedmont CA, US
Hong Liu - Castro Valley CA, US
Catherine Greer - Emeryville CA, US
Mark Selby - San Francisco CA, US
Christopher Walker - Blacklick OH, US

Assignee:

Novartis Vaccines and Diagnostics, Inc. - Emeryville CA

International Classification:

C12N 15/00
A61K 39/21

US Classification:

435 691, 4353201, 4242081

Abstract:

The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.

US Patent:

7897155, Mar 1, 2011

Filed:

Dec 11, 2008

Appl. No.:

12/316310

Inventors:

Daniela Tornese Buonamassa - Siena, IT
Catherine E. Greer - Oakland CA, US
Cesira L. Galeotti - Montegriggioni, IT
Giuliano Bensi - Florence, IT
Roberto Petracca - Siena, IT

Assignee:

Novartis Vaccines & Diagnostics, Inc. - Emeryville CA

International Classification:

A61K 39/12

US Classification:

4242041, 435 691

Abstract:

Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLPs induced the production of conformational antibodies against both L1 proteins upon administration to mice.

US Patent:

8168418, May 1, 2012

Filed:

Apr 30, 2010

Appl. No.:

12/770905

Inventors:

Susan W Barnett - San Francisco CA, US
Jan Zur Megede - San Francisco CA, US
Indresh Srivastava - Concord CA, US
Ying Lian - Vallejo CA, US
Karin Hartog - Piedmont CA, US
Hong Liu - Castro Valley CA, US
Catherine Greer - Oakland CA, US
Mark Selby - San Francisco CA, US
Christopher Walker - Blacklick OH, US

International Classification:

C12N 7/00
A61K 39/21

US Classification:

4352351, 4242081

Abstract:

The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.

US Patent:

20030223964, Dec 4, 2003

Filed:

Mar 11, 2003

Appl. No.:

10/387336

Inventors:

Susan Barnett - San Francisco CA, US
Jan Megede - San Francisco CA, US
Ying Lian - Vallejo CA, US
Karin Hartog - Piedmont CA, US
Hong Liu - Castro Valley CA, US
Catherine Greer - Oakland CA, US
Mark Selby - Berkeley CA, US

International Classification:

A61K048/00
C12N007/01
C12N015/867

US Classification:

424/093200, 435/456000, 435/235100, 435/325000

Abstract:

The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.