Catherine K Kuo from 1902 T St NW, Washington, DC 20009, age 51

Us Patents

Scaffolds For Tissue Engineering And Regenerative Medicine
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US Patent:

20110293685, Dec 1, 2011
Filed:

Oct 5, 2009
Appl. No.:

13/122414
Inventors:

Catherine K. Kuo - Boston MA, US
Nathan Zamarripa - Freeport ME, US
Amelia H. Thomas - Medford MA, US
Assignee:

TRUSTEES OF TUFTS COLLEGE - Medford MA
International Classification:

A61K 9/70
A61P 17/00
A61K 35/12
US Classification:

424422, 424400, 424 937
Abstract:

The methods and compositions described herein relate to novel 3-dimensional porous scaffolds useful for tissue re-generation, enhancement, or tissue repair. Electrospinning or other methods are used to create mats comprised of fibers that can be seeded with cells and subsequently rolled into a desired shape/form to replace a desired tissue.

Bioreactor Chamber Apparatus, And Method And System For Fabricating And Mechanically Stimulating Natural And Engineered Tissues
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US Patent:

20080274545, Nov 6, 2008
Filed:

Mar 2, 2006
Appl. No.:

11/885488
Inventors:

Catherine K. Kuo - Boston MA, US
Rocky S. Tuan - Bethesda MD, US
Mard A. Winslow - Carver MN, US
Assignee:

Government of the US, as represented by the Secret - Rockville MD
International Classification:

C12N 5/02
C12M 3/00
US Classification:

435395, 4352891, 4352921
Abstract:

A bioreactor chamber assembly including a bioreactor chamber and an outer chamber assembly is provided. In one design, the bioreactor chamber includes an upper grip assembly having a plurality of struts extending downward terminating in upper grips, each strut terminating in an upper grip, and a lower grip assembly containing one or more sample compartments and a lower grip. A sample can be formed in situ via injection into a sleeve contained within the sample compartment, where the sleeve encloses the upper and lower grips and enables a construct to form attached to these grips. In a second design, a split mold is received in the bioreactor chamber, the split mold having a cavity for receiving the upper and lower grips. Tissue explants and engineered constructs can be held within these grips. Medium level in the sample compartment is controlled, and different lengths of samples can be accommodated in the sample compartment. The height of the upper grip is adjustable by raising or lowering an extension rod that passes through a dynamic seal to the environment outside the chamber. The bioreactor chamber sample compartment includes a window to permit visualization of the sample as well as light-mediated transformation of biomaterials within the sample compartment. The samples held by grips within these chambers can be subject to uniaxial mechanical stimulation. Medium is perfused around the samples, and medium may be sampled via access ports.

Enhancing Tissue Mechanical Properties
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US Patent:

20200268935, Aug 27, 2020
Filed:

Feb 25, 2020
Appl. No.:

16/800151
Inventors:

- Rochester NY, US
Catherine K. Kuo - Rochester NY, US
Assignee:

University of Rochester - Rochester NY
International Classification:

A61L 27/24
A61L 27/38
A61B 5/00
A61L 27/54
Abstract:

The present invention relates to enhancing mechanical properties of tissue such as collagenous or collagen-containing or elastin-containing tissue (e.g., tendons, ligaments, and cartilage) and treating related musculoskeletal and non-musculoskeletal conditions or injuries.