Catherine A Patterson

US Patent:

20140350052, Nov 27, 2014

Filed:

Aug 29, 2012

Appl. No.:

14/241388

Inventors:

- Tampa FL, US
Catherine Newton - Land of Lakes FL, US
Catherine Patterson - Lutz FL, US
Marisela Agudelo - Miami FL, US

International Classification:

A61K 31/454

US Classification:

514322

Abstract:

The present disclosure provides methods and pharmaceutical compositions for reducing the serum level of immunoglobulin IgE in an animal or human subject. It has been found that reducing or inhibiting the activity of the cannabinoid receptor CB2 leads to an increase in IgE in serum levels. Conversely, activation of the CB2 receptor by an agonist results in a reduction in IgE serum levels. The compositions and methods of the disclosure, therefore, provide a means to reduce or eliminate symptoms of immune system-related conditions resulting from IgE generation, such as an allergy, hay fever, and the like.