Cato Thomas Laurencin

US Patent:

6689166, Feb 10, 2004

Filed:

Oct 8, 2002

Appl. No.:

10/267133

Inventors:

Cato T. Laurencin - Elkins Park PA
Frank K. Ko - Philadelphia PA

Assignee:

Drexel University - Philadelphia PA

International Classification:

A61F 202

US Classification:

623 1111, 623 2374

Abstract:

Tissue engineering devices with enhanced cell adhesion, cell proliferation and directional growth are provided which are prepared from nonwoven nanofibril matrices.

US Patent:

7235295, Jun 26, 2007

Filed:

Sep 10, 2004

Appl. No.:

10/938493

Inventors:

Cato T. Laurencin - Earlysville VA, US
Lakshmi Sreedharan Nair - Charlottesville VA, US
Subhabrata Bhattacharyya - Charlottesville VA, US
Harry R. Allcock - State College PA, US
Jared D. Bender - State College PA, US
Paul W. Brown - State College PA, US
Yaser E. Greish - State College PA, US

International Classification:

D02G 3/00
A61F 2/02
A61B 17/06
B29C 70/08

US Classification:

428364, 623 2374, 623 1111, 606222, 428 363

Abstract:

Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, either non-degradable or degradable. In a preferred embodiment demonstrated in the following examples, nanofibers are formed of biodegradable and non biodegradable polyphosphazenes, their blends with other polyphosphazenes or with organic, inorganic/organometallic polymers as well as composite nanofibers of polyphosphazenes with nanosized particles such as hydroxyapatites.

US Patent:

7727539, Jun 1, 2010

Filed:

Mar 14, 2002

Appl. No.:

10/469617

Inventors:

Cato T. Laurencin - Earlysville VA, US
Archel M. A. Ambrosio - San Diego CA, US
Janmeet S. Sahota - New Providence NJ, US

Assignee:

Drexel University - Philadelphia PA

International Classification:

A61K 9/00

US Classification:

424400, 977700

Abstract:

A bioresorbable composite of a non-crystalline calcium phosphate ceramic synthesized within an encapsulating microspheres of bioresorbable polymeric material for use in bone repair and replacement is provided. Also provides are methods for producing these composites as well as porous, 3-dimensional scaffold produced by sintering together microspheres of this bioresorbable composite.

US Patent:

8137972, Mar 20, 2012

Filed:

May 30, 2007

Appl. No.:

11/755254

Inventors:

Cato T. Laurencin - Elkins Park PA, US
Solomon R. Pollack - North Wales PA, US
Elliot Levine - Cherry Hill NJ, US
Edward Botchwey - Philadelphia PA, US
Helen H. Lu - New York NY, US
Mohammed Yusuf Khan - Philadelphia PA, US

Assignee:

Drexel University - Philadelphia PA
The Wistar Institute - Philadelphia PA
The Trustees Of The University of Pennsylvania - Philadelphia PA

International Classification:

C12N 5/00
C12N 5/02
C12N 5/07
C12N 11/08
C12N 11/04
A61F 2/00

US Classification:

435396, 424423, 424 937, 435180, 435182, 435325

Abstract:

Scaffolds for tissue engineering prepared from biocompatible, biodegradable polymer-based, lighter than or light as water microcarriers and designed for cell culturing in vitro in a rotating bioreactor are provided. Methods for preparation and use of these scaffolds as tissue engineering devices are also provided.

US Patent:

8486143, Jul 16, 2013

Filed:

Dec 30, 2009

Appl. No.:

12/649913

Inventors:

Cato T. Laurencin - Avon CT, US
Mark T. Aronson - Midlothian VA, US
Lakshimi Sreedharan Nair - Avon CT, US

Assignee:

Soft Tissue Regeneration, Inc. - New Haven CT

International Classification:

A61F 2/08

US Classification:

623 1314

Abstract:

A multi-region device for repair, regeneration or reconstruction in articular tissue injury such as torn ligaments and tendons is provided. The device comprises at least one degradable material and biocompatible non-degradable polymeric fiber-based material, in a three-dimensional braided scaffold. The two end sections are designed for attachment of the device at the site of implantation and are designed to allow bone cell ingrowth, and one or more middle regions are designed to allow ligament or tendon cell ingrowth.

US Patent:

8536230, Sep 17, 2013

Filed:

Jan 25, 2007

Appl. No.:

12/162057

Inventors:

Cato T. Laurencin - Earlysville VA, US
Lakshmi Sreedharan Nair - Charlottesville VA, US

Assignee:

University of Virginia Patent Foundation - Charlottesville VA

International Classification:

A61K 47/04
A61K 47/36

US Classification:

514769, 524777

Abstract:

The present invention provides a method for preparing chitosan solutions to allow regulating the conditions in which the chitosan solution will gel. The present invention also provides methods for using chitosan solutions as compositions and for using chitosan solutions in vitro and in vivo.

US Patent:

8614189, Dec 24, 2013

Filed:

Sep 21, 2009

Appl. No.:

12/586345

Inventors:

Cato T. Laurencin - Avon CT, US
Syam Prasad Nukavarapu - New Britain CT, US
Sangamesh G. Kumbar - South Windsor CT, US

Assignee:

University of Connecticut - Farmington CT

International Classification:

A61P 19/08
A61K 38/18
A61F 2/28

US Classification:

514 167, 514 76, 623 2372, 623 2373, 977742, 977745, 977748, 977752, 977753, 977778, 977904, 977908

Abstract:

The present invention provides biocompatible composite materials that can be fabricated into a scaffold having properties suitable for bone repair and regeneration. These scaffolds have sufficient mechanical strength to be useful for the repair and regeneration of cortical bone.

US Patent:

20020133229, Sep 19, 2002

Filed:

Jun 11, 2001

Appl. No.:

09/878641

Inventors:

Cato Laurencin - Elkins Park PA, US
Frank Ko - Philadelphia PA, US
James Cooper - Philadelphia PA, US
Helen Lu - Philadelphia PA, US
Mohammed Attawia - Wayne PA, US

International Classification:

A61F002/08

US Classification:

623/013170, 623/013190

Abstract:

Degradable, polymeric fiber-based, three-dimensional braided scaffolds for use as graft materials in ligament and tendon repair, reconstruction and replacement are provided. Also provided are methods for preparing these scaffolds.