Cecily J Periana

US Patent:

20070215538, Sep 20, 2007

Filed:

Mar 20, 2006

Appl. No.:

11/378484

Inventors:

Cecily Periana - Cambridge MA, US
Mark Davis - Millville MA, US
Ron Sostek - Newton MA, US

Assignee:

Harvard Apparatus, Inc. - Holliston MA

International Classification:

B01D 63/00

US Classification:

210321600, 210500100, 210500270, 422101000

Abstract:

This invention relates to equilibrium dialysis systems and methods. More particularly, the invention relates to pre-assembled or ready-to-use single-well or multi-well dialysis systems that are disposable in their entirety, comprising a molded block for performing equilibrium dialysis of one or more samples. Such equilibrium dialysis systems can be used for protein binding assays, molecule-molecule interaction studies, tissue cultures and many other biological and chemical applications. Such equilibrium dialysis systems are suitable for use in manual or high throughput formats.

US Patent:

20050254995, Nov 17, 2005

Filed:

May 12, 2004

Appl. No.:

10/843615

Inventors:

Ronald Sostek - Holliston MA, US
Cecily Periana - Holliston MA, US
Mark Davis - Holliston MA, US

Assignee:

Harvard Apparatus, Inc. - Holliston MA

International Classification:

G01N021/00

US Classification:

422056000, 422070000

Abstract:

The invention provides devices and methods using assemblies of shaped inserts coated with diverse binder materials optionally positioned inside conformal housings. The devices are capable of immobilizing target analytes of interest (e.g., specific or groups of biomolecules) and are optionally usable as single units, linear strips or array formats. The coatings on the inserts and, optionally also on the inside walls of the housings, create variable gaps with narrow fluid paths resulting in enhanced diffusion and absorption of target analytes from transiting fluid samples while exhibiting minimal resistance to flow or back pressure commonly seen in conventional plug-type packings. The devices are intended for sample preparations requiring: filtering, enriching, separating, purifying of target analytes by selective absorption/elution as part of desalting, buffer exchange and/or enrichment applications in analyses by mass spectrometry and/or electrophoresis; purifying biomolecules; culturing cells; analytical separation processes, and general chemical, biological and/or biochemical separations in manual or automated systems.