Xiaoyong Fu - Edison NJ, US Jianguo Yin - Edison NJ, US Timothy McAllister - Westfield NJ, US Cesar Colon - Rio Piedras PR, US
International Classification:
C07C069/73
US Classification:
560/060000, 560/183000
Abstract:
A single batch process for preparing (R)-benzyl-4-hydroxy-2-pentynoate by reacting (R)-3-butyn-2-ol with 1,1,1,3,3,3-hexamethyldisilazane to silylate the starting alcohol, followed by deprotonation with an alkyl lithium compound, then a reaction with a haloformate compound, and finally a hydrolysis reaction to arrive at the product ester.
Process For Preparing Albuterol, Acetal, Hemi-Acetal, And Hydrates Of Arylglyoxal Intermediates Thereof
T. K. Thiruvengadam - Edison NJ John Chiu - Parsippany NJ Michael Green - Paterson NJ Timothy L. McAllister - Fords NJ Cesar Colon - Rahway NJ Junning Lee - Springfield NJ
Assignee:
Schering Corp. - Kenilworth NJ
International Classification:
C07C 6976 C07F 502
US Classification:
560 53
Abstract:
The preparation of arylethanolamines, and in particular albuterol (salbutamol), together with their novel boron, acetal and hemi-acetal intermediates is described.
Xiaoyong Fu - Edison NJ Timothy L. McAllister - Westfield NJ John S. Chiu - Parsippany NJ Cesar Colon - Rahway NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D205/08;263/26
US Classification:
540200
Abstract:
This invention provides a process for preparing the hypocholesterolemic compound ##STR1## comprising: (a) reacting p-fluorobenzoylbutyric acid with pivaloyl chloride and acylating the product with a chiral auxiliary to obtain a ketone of formula IV: ##STR2## (b) reducing the ketone of formula IV in the presence of a chiral catalyst to an alcohol: (c) reacting the chiral alcohol of step (b), an imine and a silyl protecting agent, then condensing the protected compounds to obtain a. beta. -(substituted-amino)amide of formula VII: ##STR3## (d) cyclizing the. beta. -(substituted-amino)amide of formula VII with a silylating agent and a fluoride ion catalyst to obtain a protected lactam of the formula VIII: ##STR4## and removing the protecting groups. The intermediates of formulas VII and VIII are also claimed.
Process For The Stereospecific Synthesis Of Azetidinones
Junning Lee - Springfield NJ Timothy McAllister - Fords NJ Cesar Colon - Rahway NJ Derek H. R. Barton - College Station TX Ronald Breslow - Englewood NJ Anantha Sudhakar - East Brunswick NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D20508
US Classification:
540200
Abstract:
This invention provides an improved process for producing azetidinones. More particularly, this invention provides the steps of producing an trans-azetidinone represented by the formula ##STR1## from a carboxylic acid R. sup. 2 --D--CH. sub. 2 COOH, an aldehyde R. sup. 1 --A--CHO and an amine RNH. sub. 2, by the steps of: (a1) converting a carboxylic acid to the corresponding acid chloride; (b1) deprotonating a chiral oxazolidinone and treating the resulting anion with the product of step (a1); (c1) enolizing the product of step (b1) and condensing with the aldehyde; (d1) hydrolyzing the product of step (c1); (e1) condensing the product of step (d1) with the amine; and (f1) cyclizing the product of step (e1). Alternatively, the process comprises (a2) enolizing the product of step (b1) and condensing, in the presence of a Lewis acid, with a Schiff's base prepared from the aldehyde and the amine; and (b2) cyclizing the product of step (a2).
John S. Chiu - Parsippany NJ Cesar Colon - Roselle Park NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
A61K 3171 C07H 1522 C07D 704
US Classification:
536 139
Abstract:
A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2' positions, and optionally at the 4' position, converting the 1-amino substituent to a 1-N-imino substituent, converting the imino to an ethylamino, deprotecting the compound and recovering netilmicin. Also disclosed are novel intermediate compounds.
Process For Preparing Delta 9, 11 And 21-Chlorocorticosteroids
Xiaoyong Fu - Edison NJ Junning Lee - Gillette NJ Cesar Colon - Rahway NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07J 7500
US Classification:
552581
Abstract:
Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl. sub. 5, PCl. sub. 3, POCl. sub. 3 or either SO. sub. 2 Cl. sub. 2 and imidazole, or PPh. sub. 3 and CCl. sub. 4. The disclosed process selectively forms. DELTA. sup. 9,11 steroids from either 11-. alpha. - or 11-. beta. -hydroxy steroids, and can also be used for the one-step conversion of 11,21 -dihydroxy steroids to 21-chloro-. DELTA. sup. 9,11 steroids. Also disclosed are processes for the regioselective conversion of 11-. beta. -chloro steroids to. DELTA. sup. 9,11 steroids, and for regioselectively converting an 11,17,21-trihydroxy streoid to a 21-chloro-11,17-dihydroxy steroid.
Process For Preparing Delta 9,11 And 21-Chloro Corticosteroids
Xiaoyong Fu - Edison NJ Junning Lee - Gillette NJ Cesar Colon - Rahway NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07J 500 C07J 700 C07J 7500
US Classification:
552595
Abstract:
Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl. sub. 5, PCl. sub. 3, POCl. sub. 3 or either SO. sub. Cl. sub. 2 and imidazole, or PPh. sub. 3 and CCl. sub. 4. The disclosed process selectively forms. increment. sup. 9,11 steroids from either 11-. alpha. - or 11-. beta. -hydroxy steroids, and can also be used for the one-step conversion of 11,21-dihydroxy steroids to 21-chloro-. increment. sup. 9,11 steroids.
Customer Accounts Manager / Sales Manager / GMIT at Aarons
Location:
Atlanta, Georgia
Industry:
Retail
Work:
Aarons - Greater Atlanta Area since Jul 2012
Customer Accounts Manager / Sales Manager / GMIT
Georgia Retail - Marietta, Georgia Jul 2007 - Mar 2012
Store Manager
G L E D R - Cartersville, Georgia Jan 2008 - Sep 2010
Vice Chairmen / COO
Fast Cash Check Cashing - Miami/Fort Lauderdale Area May 2005 - Jun 2007
Director of Operations
Blockbuster, Inc Aug 1997 - Jan 2005
District Operations Manager
Education:
Enterprise State Jr. College 1994 - 1996
Associates, Business
MannHeim American H.S. 1989 - 1993
Diploma, Business,Accounting
Skills:
Multilingual Able To Multi-task PowerPoint Excel Profitability Analysis Forklift Operator Loss Prevention Shrink Reduction Inventory Management HR Policies HR Strategy Training & Development Mentoring Business Turnaround Spanish Cash Management Organizational Leadership Operations Management Microsoft Office Multi-site Sales Management E-Verify ADP Payroll Coaching Staff Training Staff Management Staffing Analysis Retail Warehouse Management Problem Solving Leadership Development Team Leadership Strategic Leadership
Blockbuster District MVP 1998, Customer Service Award (100% Secret Shop) 2002, Top Sells in the region 2003, Highest mystery shop avg. in the region award 2003, Outstanding Compliance in 2001, exceptional training district store leader 2000, top district trainer in the region 2001 and 2002, customer service company award 2002, best store appearance in the region 2001 and 2002.
Was invited to be part of the Children Miracle Network and Blockbuster commercial featuring NFL Star Steve Young in 2004.
Received recognition of participation in the support of: Glades Masters Bass Youth Club Tournament 2002 thru 2004, City of Coconut Creek Parks and Recreation Teen Club 1999 and 2000, Regency lakes Social Commitee 1999, Big Brothers and Big Sisters of Palm Beach County 2003, Childrens Miracle Network 1997 thru 2004
In 1996, Mr. Colón helped out to bring the first Puerto Rican Olympic Softball team to Enterprise, Alabama.
Languages:
English Spanish
Awards:
Perfect Year 100% Secret Shop Blockbuster Inc. Received 100% score on all secret shops through out the 2002 year. Highest Regional Shop Average Blockbuster Inc. Had the highest mystery shop average for 2003 in the Region. Customer Service Award Blockbuster Inc. Providing the best customer satisfaction Best Store Appearance Award Blockbuster Best store appearance in the Region. I also got the same award in 2002 Outstanding Compliance Award Blockbuster Meeting and exceding all companies goals Exceptional Training Leader Blockbuster Providing the best district training Top District Trainer in the Region Blockbuster Provided the best training and also I received this award for 2002. District MVP Louis Santiago I got the MVP for providing the best customer service, company compliance and turning arround several stores. Tope Sells Award Blockbuster Having the highest sells in the Region Recognition for successful first half of the year Mike Roemer (EVP, COO) Successful first half of the year and for providing outstanding customer service. 100+ PHONE SHOP AWARD Aarons Phone shop award for the month of October. Received 120 (100 plus 20 bonus points) on secret phone shop. Ultimate Double Pro Certification Aarons Finished all training for all departments in Aarons. Usually takes over a year to received this certification.
Cesar Colon (1985-1986), John Bush (1996-2000), Mary Sieli (1975-1979), Patrick Bifulco (1974-1978), Tara Covell (1988-1992), Matthew Troiano (1972-1976)