Chad Allen Wolfe

US Patent:

7417064, Aug 26, 2008

Filed:

Oct 24, 2003

Appl. No.:

10/532657

Inventors:

Serge Louis Boulet - Fishers IN, US
Sandra Ann Filla - Brownsburg IN, US
Peter Thaddeus Gallagher - Surrey, GB
Kevin John Hudziak - Indianapolis IN, US
Anette Margareta Johansson - Indianapolis IN, US
Rushad E. Karanjawala - Zionsville IN, US
John Joseph Masters - Fishers IN, US
Victor Giulio Matassa - Hirschberg, DE
Brian Michael Mathes - Indianapolis IN, US
Richard Edmund Rathmell - Ash Vale, GB
Maria Ann Whatton - Bracknell, GB
Chad Nolan Wolfe - Noblesville IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31/381
C07D 333/64

US Classification:

514443, 549 51

Abstract:

There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from C-Calkyl, C-Calkenyl, C-Ccycloalkyl and C-Ccycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, —CF, —CN and —CONH; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, 5 substituents each independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, nitro, acetyl, —CF, —SCFand cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C-Calkyl; Z is selected from H, ORor F, wherein Ris selected from H, C-Calkyl and phenyl C-Calkyl; Rand Rare each independently H or C-Calkyl; with the proviso that, when Z is H, then Y may not be optionally substituted phenyl or optionally substituted naphthyl.

US Patent:

20060058360, Mar 16, 2006

Filed:

Oct 24, 2003

Appl. No.:

10/532765

Inventors:

Serge Boulet - Fishers IN, US
Sandra Filla - Brownsburg IN, US
Peter Gallagher - Basingstoke GBN, US
Kevin Hudziak - Indianapolis IN, US
Anette Johansson - Indianapolis IN, US
Rushad Karanjawala - Zionsville IN, US
John Masters - Fishers IN, US
Brian Mathes - Indianapolis IN, US
Richard Rathmell - Basingstoke GBN, US
Maria Whatton - Basingstoke, GB
Victor Matassa - Heidelberg, DE
Chad Wolfe - Noblesville IN, US

International Classification:

A61K 31/428
A61K 31/425
C07D 277/62
C07D 275/06

US Classification:

514367000, 514373000, 548152000, 548207000

Abstract:

There is provided a heretoaryloxy/thio 3-substituted propanamine compound of formula (I) wherein A is selected from —)— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C-Calkyl and C-Calkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C-Calkyl, and C-Calkyl, C-Calkenyl, C-Ccycloalkyl and C-Ccycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl —S(O)— where n is 0, 1 or 2, —CF, —CN and —CONH; Y is selected from dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, and thienopyridyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is or , nitro acetyl, —CF, —SCFand cyano; Z is selected from H, ORor F, wherein Ris selected from H, C-Calkyl and phenyl CCalkyl; Rand Rare each independently H or C-Calkyl; and pharmaceutically acceptable salts thereof.

US Patent:

20060217372, Sep 28, 2006

Filed:

Sep 17, 2003

Appl. No.:

10/526960

Inventors:

Mark Chappell - Noblesville IN, US
Marta De La Torre - Madrid, ES
Nuria Diaz Buezo - Madrid, ES
James Fritz - McCordsville IN, US
William Holloway - Zionsville IN, US
James Matt - Fishers IN, US
Charles Mitch - Columbus IN, US
Concepcion Pedregal-Tercero - Madrid, ES
Miles Siegel - Indianapolis IN, US
Dana Smith - Westfield IN, US
Russell Stucky - Indianapolis IN, US
Kumiko Takeuchi - Indianapolis IN, US
Elizabeth Thomas - Columbus IN, US
Chad Wolfe - Noblesville IN, US

International Classification:

A61K 31/541
A61K 31/5377
A61K 31/501
A61K 31/506
A61K 31/497
A61K 31/496
C07D 417/02
C07D 413/02
C07D 403/02

US Classification:

514227500, 514234200, 514235500, 514252020, 514252110, 514252140, 514255050, 544060000, 544238000, 544295000, 544357000, 544405000

Abstract:

A compound of the formula (I) wherein the variables Xto X, Rto Rincluding R, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.

US Patent:

20080255152, Oct 16, 2008

Filed:

Mar 21, 2008

Appl. No.:

12/052994

Inventors:

Mark Donald Chappell - Noblesville IN, US
Marta Garcia De La Torre - Madrid, ES
Nuria Diaz Buezo - Madrid, ES
James Erwin Fritz - McCordsville IN, US
William Glen Holloway - Zionsville IN, US
James Edward Matt - Flshers IN, US
Charies Howard Mitch - Columbus IN, US
Concepcion Pedregal-Tercero - Madrid, ES
Steven James Quimby - Noblesville IN, US
Miles Goodman Siegel - Indianapolis IN, US
Dana Rae Smith - Westfield IN, US
Russell Dean Stucky - Indianapolis IN, US
Kumiko Takeuchi - Indianapolis IN, US
Elizabeth Marie Thomas - Columbus IN, US
Chad Nolan Wolfe - Noblesville IN, US

International Classification:

A61K 31/497

US Classification:

51425505

Abstract:

A compound of the formula (I) wherein the variables Xto X, Rto Rincluding R, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.

US Patent:

20080269296, Oct 30, 2008

Filed:

Mar 21, 2008

Appl. No.:

12/052972

Inventors:

Mark Donald Chappell - Noblesville IN, US
Marta Garcia De La Torre - Madrid, ES
Nuria Diaz Buezo - Madrid, ES
James Erwin Fritz - McCordsville IN, US
William Glen Holloway - Zionsville IN, US
James Edward Matt - Fishers IN, US
Charles Howard Mitch - Columbus IN, US
Concepcion Pedregal-Tercero - Madrid, ES
Steven James Quimby - Noblesville IN, US
Miles Goodman Siegel - Indianapolis IN, US
Dana Rae Smith - Westfield IN, US
Russell Dean Stucky - Indianapolis IN, US
Kumiko Takeuchi - Indianapolis IN, US
Elizabeth Marie Thomas - Columbus IN, US
Chad Nolan Wolfe - Noblesville IN, US

International Classification:

A61K 31/4433
A61P 25/32

US Classification:

514336

Abstract:

A compound of the formula (I) wherein the variables Xto X, Rto Rincluding R, E, v, y, z. A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.

US Patent:

7410996, Aug 12, 2008

Filed:

Oct 24, 2003

Appl. No.:

10/533328

Inventors:

Serge Louis Boulet - Fishers IN, US
Sandra Ann Filla - Brownsburg IN, US
Peter Thaddeus Gallagher - Surrey, GB
Kevin John Hudziak - Indianapolis IN, US
Anette Margareta Johansson - Indianapolis IN, US
Rushad E. Karanjawala - Zionsville IN, US
John Joseph Masters - Fishers IN, US
Victor Giulio Matassa - Hirschberg, DE
Brian Michael Mathes - Indianapolis IN, US
Richard Edmund Rathmell - Ash Vale, GB
Maria Ann Whatton - Bracknell, GB
Chad Nolan Wolfe - Noblesville IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31/381
C07D 333/64

US Classification:

514443, 549 51

Abstract:

There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C-Calkyl and C-Calkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C-Calkyl, and C-Calkyl, C-Calkenyl, C-Ccycloalkyl and C-Ccycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, —CF, —CN and —CONH; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, nitro, acetyl, —CF, —SCFand cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C-Calkyl; Z is selected from ORor F, wherein Ris selected from H, C-Calkyl and phenyl C-Calkyl; Rand Rare each independently H or C-Calkyl; and pharmaceutically acceptable salts thereof with the proviso that when Y is optionally substituted phenyl or optionally substituted 1,3-benzodioxolyl and Z is ORand X is optionally substituted phenyl then A is —S—.