Research Assistant at Case Western Reserve University: Control & Energy Systems Center Lab Cleveland, Ohio
Location:
Cleveland, Ohio
Industry:
Electrical/Electronic Manufacturing
Work:
Case Western Reserve University: Control & Energy Systems Center Lab Cleveland, Ohio - Cleveland/Akron, Ohio Area since Aug 2012
Research Assistant
Education:
Case Western Reserve University 2012 - 2013
Master of Engineering (MEng), Electrical and Electronics Engineering
Abilene Christian University, Abilene, Texas 2009 - 2011
Bachelors of Science Engineering, Engineering Management
South China University of Technology 2006 - 2009
Bachelor of Engineering (B.Eng.), Electrical and Electronics Engineering
Mathematics Office Equipment Powerpoint Soccer Boston Sports C Algebra Calculus Stamps Coins Chinese English England Lin Asia Collecting Posters Microsoft Word Java Medicine Microsoft Excel Cisco Networking Fair Use Typing Cantonese Cashiering Design Donuts Filing Mandarin Smoking
Itri
Senior Researcher
Itri Apr 2010 - Jun 2017
Researcher
National Renewable Energy Laboratory May 2011 - Nov 2011
Visiting Researcher
National Chiao Tung University Sep 2009 - Mar 2010
Post Study Doctor
Sep 2009 - Mar 2010
Associate Researcher
Education:
National Chiao Tung University 2005 - 2009
Doctorates, Doctor of Philosophy, Semiconductor Manufacturing, Philosophy
Skills:
Electronics Solar Cells Semiconductor Process Technology Semiconductor Device Tcad Semiconductor Memory Pecvd
Accurate Technologies
Business Manager
Accurate Technologies
Application Engineering Manager
Accurate Technologies Mar 2014 - May 2018
Application Engineer
Yokogawa Apr 2012 - Nov 2013
Engineer
Education:
Waseda University 2019 - 2021
Master of Business Administration, Masters
Udacity 2017 - 2018
Osaka University 2010 - 2012
Masters, Mechanical Engineering
Shanghai Jiao Tong University 2005 - 2009
Bachelors, Mechanical Engineering
Skills:
Python C/C++ Self Driving Car Basis Ecu Measurement/Calibration Tool Network and Communication Android Development Java
Languages:
Mandarin Japanese English
Certifications:
基本情報技術者試験(Fundamental Information Technology Engineer Examination) 応用情報技術者試験(Applied Information Technology Engineer Examination) エンベデッドシステムスペシャリスト試験(Embedded Systems Specialist Examination) 情報セキュリティマネジメント(Information Security Management)
Washington University School of Medicine In St. Louis Jan 1, 1990 - Dec 31, 1995
Doctorates, Doctor of Philosophy, Microbiology, Virology
Institute of Biochemistry, Academy Sinica Jan 1, 1985 - 1988
Master of Science, Masters, Biochemistry
Fudan University Jan 1, 1981 - Dec 31, 1985
Bachelors, Biochemistry
Skills:
Oncology Bioanalysis Ion Channels Synthetic Organic Chemistry Chemstation Study Coordination Nir Spectroscopy Genomics In Vivo Infectious Diseases Drug Development Hcv Assay Development Pharmacology Biomarker Discovery Biotechnology
Charles Schwab
Director, Risk Analytics and Modeling
Charles Schwab Nov 2015 - Jun 2018
Senior Manager, Risk Analytics and Modeling
Charles Schwab Jan 2015 - Oct 2015
Manager, Risk Analytics and Modeling
Citizens Financial Group, Inc. Jun 2013 - Dec 2014
Senior Quantitative Analyst, Assistant Vice President
Boston University Questrom School of Business Jun 2013 - Dec 2014
Education:
Boston University - School of Management 2012 - 2014
Master of Science (M.S.), Mathematical Finance
University of Pittsburgh 2008 - 2011
Bachelor of Business Administration (B.B.A.), Finance
Southwestern University of Finance and Economics 2007 - 2008
Skills:
R Statistics C++ Matlab Quantitative Analytics Photoshop Spreadsheets Time Series Analysis Credit Risk Stochastic Processes Quantitative Models Linear Regression Survival Analysis Data Visualization Sas Ipython Notebook Data Mining Machine Learning Python Sql Interest Rate Risk Management C# Language Integrated Query
Languages:
English Mandarin
Certifications:
Neural Networks and Deep Learning Improving Deep Neural Networks: Hyperparameter Tuning, Regularization and Optimization Structuring Machine Learning Projects Convolutional Neural Networks Sequence Models
Us Patents
Crystals Of Hepatitis C Virus Helicase Or Fragments Thereof Comprising A Helicase Binding Pocket
Joseph L. Kim - Natick MA, US Kurt Morgenstern - Derry NH, US Paul Caron - Malden MA, US Chao Lin - Brookline MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
A61K 39/29 A61K 38/43 G01N 33/53 C12N 9/00
US Classification:
4242281, 435 71, 435183, 514 2, 514 12
Abstract:
The invention relates to the X-ray crystal structure of the hepatitis C virus helicase domain. More specifically, the invention relates to crystallized complexes of HCV helicase and an oligonucleotide, to crystallizable compositions of HCV helicase and an oligonucleotide and to methods of crystallizing an HCV helicase-oligonucleotide complex. The invention further relates to a computer programmed with the structure coordinates of the HCV helicase oligonucleotide binding pocket or the HCV helicase nucleotide triphosphate pocket wherein said computer is capable of displaying a three-dimensional representation of that binding pocket.
Chao Lin - Winchester MA, US Kai Lin - Waltham MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C12N 7/00 C07H 21/04
US Classification:
4242181, 536 231
Abstract:
The present invention is directed to mutants of HCV NS3/4A protease. More particularly, the present invention identifies mutant of HCV NS3/4A protease that are resistant to drug treatment.
The present invention relates to HCV variants, particularly variants that are resistant to a protease inhibitors such as VX-950. Also provided are methods and compositions related to the HCV variants. Further provided are methods of isolating, identifying, and characterizing multiple viral variants from a patient.
Chao Lin - Winchester MA, US Kai Lin - Waltham MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07H 23/00 C12N 7/00 C12Q 1/70
US Classification:
536 2371, 4353201, 435 691, 4352351, 435 6
Abstract:
The present invention is directed to mutants of HCV NS3/4A protease. More particularly, the present invention identifies mutant of HCV NS3/4A protease that are resistant to drug treatment.
Combination Therapy For The Treatment Of Hcv Infection
Ann Kwong - Cambridge MA, US Nagraj Mani - Natick MA, US Yi Zhou - Lexington MA, US Chao Lin - Winchester MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
A01N 43/04 A61K 31/70
US Classification:
514 49, 514 43, 514 50, 514 51
Abstract:
The present invention relates to therapeutic combinations comprising a protease inhibitor and a polymerase inhibitor for the treatment of HCV. The present invention also relates to therapeutic combinations comprising VX-950 and a polymerase inhibitor. Also within the scope of the invention are methods using the therapeutic combinations of the present invention for treating HCV infection or alleviating one or more symptoms thereof in a patient. The present invention also provides kits comprising the combinations of the present invention.
The present invention relates to HCV variants, particularly variants that are resistant to a protease inhibitors such as VX-950. Also provided are methods and compositions related to the HCV variants. Further provided are methods of isolating, identifying, and characterizing multiple viral variants from a patient.
Crystallizable Compositions Comprising A Hepatitis C Virus Ns3 Protease Domain/Ns4A Complex
Joseph Kim - Natick MA, US Kurt Morgenstern - Derry NH, US Chao Lin - Cambridge MA, US Ted Fox - Maynard MA, US John Thomson - Belmont MA, US
Assignee:
Vertex Pharmaceuticals, Incorporated
International Classification:
C12Q001/70 C12N009/50 C12N007/00
US Classification:
435/005000, 435/219000, 435/235100
Abstract:
The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
Chao Lin - Brookline MA, US Anne Kwong - Cambridge MA, US
International Classification:
C12Q001/68 C12P019/34
US Classification:
435/006000, 435/091200
Abstract:
The present invention provides a method of accurately assaying the amount of nucleic acids in a biological source. According to another embodiment, the present invention provides a method of accurately assaying HCV in a biological source. The present invention also provides a method of simultaneously screening the effect of a plurality of compounds on the replication of a whole or part of a genome of a biological source. The present invention provides a method of simultaneously screening the effect of a plurality of compounds on the replication of the whole or part of the HCV genome in a biological source.
lead author), Robert Scharpf and Paul Winnard. Collaborators from the Virginia Polytechnic Institute and State University are Ivan Akhrymuk (joint study lead author), Kylene Kehn-Hall, Lauren Panny and Amy Smith. Shih-Chao Lin from the National Taiwan Ocean University also contributed to the study.