Charles N Carpenter

US Patent:

57889686, Aug 4, 1998

Filed:

Jun 5, 1995

Appl. No.:

8/461661

Inventors:

Howard L. Weiner - Brookline MA
David Allen Hafler - West Newton MA
Charles B. Carpenter - Weston MA
Mohamed Sayegh - Brookline MA
Zhengyi Zhang - Malden MA

Assignee:

AutoImmune, Inc. - Lexington MA

International Classification:

A61K 3900
A61K 3938
C07K 100
C07K 1400

US Classification:

4241841

Abstract:

Disclosed herein are methods for suppressing allograft rejection in mammals comprising administering to a mammal about to undergo or having undergone allograft surgery an agent selected from the group consisting of splenic tissue from an allograft donor, splenic extracts, cultured lymphocytes from an allograft donor, extracts of said cultured lymphocytes, MHC antigens, transplantation rejection suppressive fragments and analogs of MHC antigens in an oral or aerosol form. Also disclosed herein are pharmaceutical formulations and dosage forms for use in said methods.

US Patent:

39522881, Apr 20, 1976

Filed:

Sep 30, 1974

Appl. No.:

5/510787

Inventors:

Charles Howe Carpenter - Belmont MA
Thomas Raymond Stodolski - Cambridge MA

Assignee:

Bell & Howell Company - Chicago IL

International Classification:

H04Q 1102

US Classification:

340171R

Abstract:

A linear filter network incorporating active elements, and which obeys the relation f. sub. t. varies. sqroot. G. sub. 1 G. sub. 2, where f. sub. t is the band-pass center frequency of the network; and G. sub. 1 and G. sub. 2 are the conductance values of certain network circuit elements, has its transfer function for bandpass output controlled by a group of switchable conductances (G. sub. 1 G. sub. 2) in a digitally-controllable switching system that reduces the number of conductances required to achieve a given number of discrete pass-bands all having the same, or constant, bandwidth. A network that is switchable among 10 or more frequencies is used in a tone-responsive paging system for response to one or more of a series of calling tones or frequencies that follow each other in equal frequency intervals or steps ". DELTA. f" chosen so that for a series of "n" steps no tone in the series is harmonically related to any of the others.

US Patent:

56815565, Oct 28, 1997

Filed:

Nov 29, 1993

Appl. No.:

8/159044

Inventors:

Howard L. Weiner - Brookline MA
David Allen Hafler - West Newton MA
Charles B. Carpenter - Weston MA
Mohamed Sayegh - Brookline MA
Zhengyi Zhang - Malden MA

Assignee:

Autoimmune Inc. - Lexington MA

International Classification:

A61K 4505
A61K 3816
C07K 100
C07K 1400

US Classification:

424 851

Abstract:

Disclosed herein are methods for suppressing allograft rejection in mammals comprising administering to a mammal about to undergo or having undergone allograft surgery an agent selected from the group consisting of splenic tissue from an allograft donor, splenic extracts, cultured lymphocytes from an allograft donor, extracts of said cultured lymphocytes, MHC antigens, transplantation rejection suppressive fragments and analogs of MHC antigens in an oral or aerosol form. Also disclosed herein are pharmaceutical formulations and dosage forms for use in said methods.

US Patent:

45172897, May 14, 1985

Filed:

Aug 18, 1982

Appl. No.:

6/409183

Inventors:

Edgar L. Milford - Dover MA
Charles B. Carpenter - Weston MA
Jean M. Paradysz - Brighton MA

Assignee:

Brigham and Women's Hospital - Boston MA

International Classification:

G01N 3354
C12N 500
C12N 1500
C12R 191
A61K 39395

US Classification:

435 7

Abstract:

Immortal, antibody-producing, hybridomally-produced clones which produce antibodies that react specifically with human HLA antigens and which are produced from rat lymphocyte cells sensitized against cells from a rat strain having different histocompatibility antigens are disclosed along with methods of producing the clones and antibodies and methods of using the antibodies in tissue crossing tests.

US Patent:

55936989, Jan 14, 1997

Filed:

Mar 5, 1993

Appl. No.:

8/027127

Inventors:

Howard L. Weiner - Brookline MA
David A. Hafler - West Newton MA
Charles B. Carpenter - Weston MA
Mohamed Sayegh - West Roxbury MA
Zhengyi Zhang - Needham MA

Assignee:

Autoimmune, Inc. - Lexington MA

International Classification:

A61K 3514
A01N 6300
C07K 100
C07K 1400

US Classification:

424534

Abstract:

Described are methods for: (a) suppressing the ability of T-cells from a mammal to proliferate in response to stimulation by nonself mammalian tissue; and (b) suppressing immune response which leads to allograft rejection in a mammal receiving an allograft from a donor mammal. The methods involve orally administering to the mammal to be thus treated a composition comprising at least one of: (i) a major histocompatibility complex Class II antigen from a second nonself mammal or from tissue of a mammal syngeneic to said nonself mammal; (ii) at least one synthetic peptide corresponding to a T-cell suppressive fragment of said Class II antigen, said composition being administered in an amount effective to suppress said proliferation. The foregoing compositions are also described.