Charles C Gill

US Patent:

6221859, Apr 24, 2001

Filed:

Aug 27, 1999

Appl. No.:

9/387709

Inventors:

Karen L. Dorso - Franklin Park NJ
Jesse J. Jackson - Howell NJ
Charles J. Gill - Beachwood NJ
Joyce Kohler - Woodbridge NJ
Lynn L. Silver - Westfield NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3143
A61K 31395

US Classification:

514199

Abstract:

The present invention relates to novel 2-(naphthosultamyl)methyl-carbapenem antibacterial agents or pharmaceutically acceptable salts thereof in combination with other. beta. -lactams, which are useful in treating and preventing enterococcal infections. The combinations have anti-PBP5 activity as well as activity against the critical PBPs of sensitive isolates. The antibacterial compositions of the present invention thus comprise an important contribution to therapy for treating infections caused by these difficult to control pathogens. This combination is also useful against gram positive microorganisms, especially methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant Staphylococcus epidermidis (MRSE), and methicillin resistant coagulase negative Staphylococci (MRCNS).

US Patent:

20210346364, Nov 11, 2021

Filed:

Jul 26, 2021

Appl. No.:

17/385258

Inventors:

- Rahway NJ, US
Reynalda DE JESUS - East Brunswick NJ, US
Charles J. GIll - Beachwood NJ, US
Ginny Dai HO - Murray Hill NJ, US
Sookhee N. HA - Warren NJ, US
Sandra J. KOSEOGLU - Fanwood NJ, US
Marc A. LABROLI - West Point PA, US
Sang Ho LEE - Berkeley Heights NJ, US
Mihir MANDAL - Westfield NJ, US
Terry ROEMER - Cranford NJ, US
Jing SU - Scotch Plains NJ, US
Christopher Michael TAN - Scotch Plains NJ, US
Zheng TAN - Westfield NJ, US
Haifeng TANG - Metuchen NJ, US
Hao WANG - Scotch Plains NJ, US
Christine YANG - New Brunswick NJ, US
Shu-Wei YANG - Edison NJ, US

Assignee:

MERCK SHARP & DOHME CORP. - Rahway NJ

International Classification:

A61K 31/4439
A61P 31/04
A61K 31/407
A61K 31/421
A61K 31/422
A61K 31/427
A61K 31/431
A61K 31/4375
A61K 31/438
A61K 31/4709
A61K 31/5377
A61K 31/5383
C07D 263/26
C07D 413/04
C07D 413/06
C07D 413/12
C07D 413/14
C07D 417/12
C07D 471/04
C07D 491/048
C07D 495/04
C07D 498/04

Abstract:

Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.

US Patent:

20200261436, Aug 20, 2020

Filed:

Dec 13, 2016

Appl. No.:

16/061519

Inventors:

- Rahway NJ, US
Reynalda DE JESUS - East Brunswick NJ, US
Charles J. GIll - Beachwood NJ, US
Ginny Dai HO - Murray Hill NJ, US
Sookhee N. HA - Warren NJ, US
Sandra J. KOSEOGLU - Fanwood NJ, US
Marc A. LABROLI - West Point PA, US
Sang Ho LEE - Berkeley Heights NJ, US
Mihir MANDAL - Westfield NJ, US
Terry ROEMER - Cranford NJ, US
Jing SU - Scotch Plains NJ, US
Christopher Michael TAN - Scotch Plains NJ, US
Zheng TAN - Westfield NJ, US
Haifeng TANG - Metuchen NJ, US
Hao WANG - Scotch Plains NJ, US
Christine YANG - New Brunswick NJ, US
Shu-Wei YANG - Edison NJ, US

Assignee:

MERCK SHARP & DOHME CORP. - Rahway NJ

International Classification:

A61K 31/4439
A61K 31/407
A61K 31/431
C07D 413/12
C07D 471/04
C07D 263/26
C07D 495/04
C07D 491/048
C07D 417/12
C07D 413/14
C07D 413/06
C07D 413/04
C07D 498/04
A61K 31/4709
A61K 31/438
A61K 31/421
A61K 31/4375
A61K 31/422
A61K 31/427
A61K 31/5377
A61K 31/5383
A61P 31/04

Abstract:

Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.