Charles Wynn Goolsby

US Patent:

20070105165, May 10, 2007

Filed:

Nov 4, 2005

Appl. No.:

11/267948

Inventors:

Charles Goolsby - Winfield IL, US
T. Shankey - Miami FL, US
David Hedley - Toronto, CA
James Jacobberger - Chesterland OH, US
Stanley Shackney - Pittsburgh PA, US

International Classification:

G01N 33/574

US Classification:

435007230

Abstract:

The present invention is directed to methods for establishing a composite marker profile for a sample derived from an individual suspected having a neoplastic condition. A composite marker profile of the invention allows for identification of prognostically and therapeutically relevant subgroups of neoplastic conditions and prediction of the clinical course of an individual. The methods of the invention provide tools useful in choosing a therapy for an individual afflicted with a neoplastic condition, including methods for assigning a risk group, methods of predicting an increased risk of relapse, methods of predicting an increased risk of developing secondary complications, methods of choosing a therapy for an individual, methods of determining the efficacy of a therapy in an individual, and methods of determining the prognosis for an individual. In particular, the method of the present invention discloses a method for establishing a composite marker profile that can serve as a prognostic indicator to predict whether the course of a neoplastic condition in a individual will be aggressive or indolent, thereby aiding the clinician in managing the patient and evaluating the modality of treatment to be used. In particular embodiments disclosed herein, the methods of the invention are directed to establishing a composite marker profile for a leukemia selected from the group consisting of Chronic Lymphocytic Leukemia (CLL), Acute Myelogenous Leukemia (AML), Chronic Myelogenous Leukemia (CML), and Acute Lymphocytic Leukemia (ALL).

US Patent:

20100261204, Oct 14, 2010

Filed:

Jan 29, 2010

Appl. No.:

12/696702

Inventors:

Charles GOOLSBY - Winfield IL, US
T. Vincent Shankey - Miami FL, US
David Hedley - Toronto, CA
James Jacobberger - Chesterland OH, US
Stanley Shackney - Pittsburgh PA, US

Assignee:

Beckman Coulter, Inc. - Brea CA

International Classification:

G01N 33/574

US Classification:

435 723

Abstract:

The present invention is directed to methods for establishing a composite marker profile for a sample derived from an individual suspected having a neoplastic condition. A composite marker profile of the invention allows for identification of prognostically and therapeutically relevant subgroups of neoplastic conditions and prediction of the clinical course of an individual. The methods of the invention provide tools useful in choosing a therapy for an individual afflicted with a neoplastic condition, including methods for assigning a risk group, methods of predicting an increased risk of relapse, methods of predicting an increased risk of developing secondary complications, methods of choosing a therapy for an individual, methods of determining the efficacy of a therapy in an individual, and methods of determining the prognosis for an individual. In particular, the method of the present invention discloses a method for establishing a composite marker profile that can serve as a prognostic indicator to predict whether the course of a neoplastic condition in a individual will be aggressive or indolent, thereby aiding the clinician in managing the patient and evaluating the modality of treatment to be used. In particular embodiments disclosed herein, the methods of the invention are directed to establishing a composite marker profile for a leukemia selected from the group consisting of Chronic Lymphocytic Leukemia (CLL), Acute Myelogenous Leukemia (AML), Chronic Myelogenous Leukemia (CML), and Acute Lymphocytic Leukemia (ALL).

US Patent:

20130210034, Aug 15, 2013

Filed:

Feb 28, 2013

Appl. No.:

13/781312

Inventors:

Beckman Coulter, Inc. - , US
Charles Goolsby - Winfield IL, US
David Hedley - Toronto, CA
Vincent Shankey - Miami FL, US
Phillip Woost - North Ridgeville OH, US
Sue Chow - Markham, CA
James Marvin - Evanston IL, US

Assignee:

BECKMAN COULTER, INC. - Brea CA

International Classification:

G01N 33/68

US Classification:

435 723, 435 721

Abstract:

The present specification discloses methods for determining a phosphoprotein activation profile in hematopoietic cells, methods for detecting a signal transduction activation state in an individual having or suspected of having a disease or condition associated with activation of a signal transduction pathway, methods for detecting leukemia, and kits for determining a phosphoprotein activation profile in a sample containing hematopoietic cells.