Charles V Hopper

US Patent:

6603010, Aug 5, 2003

Filed:

Nov 6, 2001

Appl. No.:

09/993046

Inventors:

Charles R. Hopper - Plainfield IN
Ramiah Murugan - Indianapolis IN
L. Mark Huckstep - Avon IN
Eric F. V. Scriven - Greenwood IN

Assignee:

Reilly Industries, Inc. - Indianapolis IN

International Classification:

C07D21302

US Classification:

546304

Abstract:

Described are preferred processes for producing extrusion-granulated supernucleophilic 4-amino-substituted pyridine catalysts, and granular products obtainable thereform. Also described are preferred activation-substitution-deactivation processes for producing 4-aminopyridine compounds, which involve the use of acrylic acid or acrylamide or analogs thereof for activation, and substitution steps conducted under mild basic conditions in an excess of the amine reagent for 4-substitution. Such processes provide improved reacted masses which are more readily processed to recover the products in pure, heat-stable form. Further, described are processes for preparing 4-substituted-pyridines via pyridine betaines.

US Patent:

6958400, Oct 25, 2005

Filed:

Apr 29, 2003

Appl. No.:

10/425504

Inventors:

Marudai Balasubramanian - Indianapolis IN, US
Joel R. Calvin - Carmel IN, US
Eric F. V. Scriven - Greenwood IN, US
Charles R. Hopper - Plainfield IN, US
Ramiah Murugan - Indianapolis IN, US
L. Mark Huckstep - Avon IN, US

Assignee:

Reilly Industries, Inc. - Indianapolis IN

International Classification:

C07D213/02

US Classification:

546304

Abstract:

Processes for preparing a 4-(secondary or tertiary)aminopyridine are provided. The processes comprise reacting a 4-substituted pyridine base having a leaving group as the 4-substituent, with an activating agent so as to form a corresponding 1,4-substituted pyridine; reacting the 1,4-substituted pyridine with a primary or secondary amine to substitute an amino group at the 4-position, and thereby form a corresponding 1-substituted-4-(secondary or tertiary) aminopyridine, wherein the reacting is conducted in a substitution reaction medium essentially free from strong base; and treating the 1-substituted-4-aminopyridine compound to remove the 1-substituent and thereby form a product medium including the 4-(secondary or tertiary) amino-pyridine.

US Patent:

7151181, Dec 19, 2006

Filed:

Feb 10, 2006

Appl. No.:

11/351783

Inventors:

Martin Grendze - Indianapolis IN, US
Ramiah Murugan - Indianapolis IN, US
L. Mark Huckstep - Avon IN, US
Charles R. Hopper - Avon IN, US

Assignee:

Reilly Industries, Inc. - Indianapolis IN

International Classification:

C07D 211/02

US Classification:

546249

Abstract:

Methods are provided for improving production of 3,5-diethyl-1,2-dihydro-1-phenyl-2-propylpyridine (DHP). In one illustrative embodiment, the methods involve controlling the rate of reaction and temperature of the reaction during formation of DHP. In another illustrative embodiment, the methods involve neutralizing the acid catalyst subsequent to DHP formation.

US Patent:

60463368, Apr 4, 2000

Filed:

Jul 31, 1998

Appl. No.:

9/127542

Inventors:

Joe W. Curtis - Plainfield IN
Charles R. Hopper - Plainfield IN
Ramiah Murugan - Indianapolis IN
L. Mark Huckstep - Danville IN
Marudai Balasubramanian - Indianapolis IN
Joel R. Calvin - Carmel IN
Eric F. V. Scriven - Greenwood IN

Assignee:

Reilly Industries, Inc. - Indianapolis IN

International Classification:

C07D21302

US Classification:

546304

Abstract:

Described are preferred processes for producing extrusion-granulated supernucleophilic 4-amino-substituted pyridine catalysts, and granular products obtainable therefrom. Also described are preferred activation-substitution-deactivation processes for producing 4-aminopyridine compounds, which involve the use of acrylic acid or acrylamide or analogs thereof for activation, and substitution steps conducted under mild basic conditions in an excess of the amine reagent for 4-substitution. Such processes provide improved reacted masses which are more readily processed to recover the products in pure, heat-stable form. Further, described are processes for preparing 4-substituted-pyridines via pyridine betaines.