Charles F Mann

US Patent:

7166622, Jan 23, 2007

Filed:

Jun 9, 2003

Appl. No.:

10/457641

Inventors:

Anthony Frank Kreft - Langhorne PA, US
Derek Cecil Cole - New City NY, US
Kevin Roger Woller - Ayer MA, US
Joseph Raymond Stock - Monroe NY, US
Kristina Martha Kutterer - Westwood NJ, US
Dennis Martin Kubrak - Philadelphia PA, US
Charles William Mann - North Wales PA, US
William Jay Moore - Collegeville PA, US
David Scott Casebier - Carlisle MA, US

Assignee:

Wyeth - Madison NJ
ArQule, Inc. - Woburn MA

International Classification:

C07C 311/17
C07D 209/14
C07D 271/12
C07D 307/52
C07D 317/08
A61K 31/18
A61K 31/34
A61K 31/357
A61K 31/4245

US Classification:

514361, 514364, 514415, 514452, 514459, 514602, 514604, 548125, 548506, 549430, 549495, 564 84, 564 90, 564 92, 564 93

Abstract:

Compounds of Formula I,.

US Patent:

7531542, May 12, 2009

Filed:

May 9, 2006

Appl. No.:

11/431266

Inventors:

Daniel M. Green - Ambler PA, US
Diane B. Hauze - Radnor PA, US
Charles W. Mann - Philadelphia PA, US
Jeffrey C. Pelletier - Lafayette Hill PA, US
Matthew D. Vera - Royersford PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/497
C07D 413/00
C07D 417/00
C07D 419/00

US Classification:

51425402, 544368

Abstract:

The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists.

US Patent:

7601722, Oct 13, 2009

Filed:

Dec 12, 2007

Appl. No.:

11/955018

Inventors:

Casey Cameron McComas - Phoenixville PA, US
Stephen Todd Cohn - Spring TX, US
Andrew Fensome - Wayne PA, US
Joel Adam Goldberg - Philadelphia PA, US
Charles William Mann - Plymouth Meeting PA, US
Michael Anthony Marella - Limerick PA, US
David John O'Neill - Collegeville PA, US
Joseph Peter Sabatucci - Collegeville PA, US
Eugene Anthony Terefenko - Center Valley PA, US
Eugene John Trybulski - Huntingdon Valley PA, US
An Thien Vu - Pottstown PA, US
Puwen Zhang - Audubon PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/496
A61K 31/5377
C07D 413/06
C07D 403/06

US Classification:

51425403, 5142342, 544134, 544368

Abstract:

The present invention is directed to aryl sulfamide derivatives of formula I:.

US Patent:

7671075, Mar 2, 2010

Filed:

Sep 27, 2006

Appl. No.:

11/528001

Inventors:

Anthony Frank Kreft - Langhorne PA, US
Derek Cecil Cole - New City NY, US
Kevin Roger Woller - Ayer MA, US
Joseph Raymond Stock - Monroe NY, US
Kristina Martha Kutterer - Westwood NJ, US
Dennis Martin Kubrak - Philadelphia PA, US
Charles William Mann - North Wales PA, US
William Jay Moore - Collegewille PA, US
David Scott Casebier - Carlisle MA, US

Assignee:

Wyeth - Madison NJ
ArQule, Inc. - Woburn MA

International Classification:

A61K 31/18
A61K 31/34
A61K 31/357
A61K 31/4245
C07C 311/17
C07D 209/14
C07D 271/12
C07D 307/52
C07D 317/08

US Classification:

514361, 514415, 514452, 514459, 514602, 514604

Abstract:

Compounds of Formula I,wherein R-Rare defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer's Disease and Down's syndrome are also described.

US Patent:

20080161366, Jul 3, 2008

Filed:

Dec 12, 2007

Appl. No.:

11/955195

Inventors:

Casey Cameron McComas - Phoenixville PA, US
Stephen Todd Cohn - Spring TX, US
Matthew Lantz Crawley - Phoenixville PA, US
Andrew Fensome - Wayne PA, US
Joel Adam Goldberg - Philadelphia PA, US
Douglas John Jenkins - Cincinnati OH, US
Callain Younghee Kim - Collegeville PA, US
Paige Erin Mahaney - Pottstown PA, US
Charles William Mann - Plymouth Meeting PA, US
Michael Anthony Marella - Limerick PA, US
David John O'Neill - Collegeville PA, US
Joseph Peter Sabatucci - Collegeville PA, US
Eugene Anthony Terefenko - Center Valley PA, US
Eugene John Trybulski - Huntingdon Valley PA, US
An Thien Vu - Pottstown PA, US
Richard Page Woodworth - North Wales PA, US
Puwen Zhang - Audubon PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/433
C07D 285/14
A61P 15/00
A61P 25/00
A61P 1/00
A61P 3/00

US Classification:

514362, 548135

Abstract:

The present invention is directed to aminoalkyl-substituted aryl sulfamide derivatives of formula I:

US Patent:

20080171737, Jul 17, 2008

Filed:

Dec 12, 2007

Appl. No.:

11/954466

Inventors:

Andrew Fensome - Wayne PA, US
Joel Adam Goldberg - Philadelphia PA, US
Casey Cameron McComas - Phoenixville PA, US
Charles William Mann - Plymouth Meeting PA, US
Edward George Melenski - Collegeville PA, US
Joseph Peter Sabatucci - Collegeville PA, US
Richard Page Woodworth - North Wales PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/551
C07D 279/02
A61K 31/5415
C07D 291/08
A61P 1/00
A61P 25/00
A61P 13/00
A61P 15/00
C07D 285/15
C07D 243/08

US Classification:

514218, 544 49, 5142265, 544 2, 5142228, 544 5, 540575

Abstract:

The present invention is directed to cyclic sulfonamide derivatives of formula I:or a pharmaceutically acceptable salt thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behaviorial disorder, cognitive disorder, diabetic neuropathy, pain, and other diseases or disorders.

US Patent:

20080194654, Aug 14, 2008

Filed:

Dec 12, 2007

Appl. No.:

11/955204

Inventors:

Casey Cameron McComas - Phoenixville PA, US
Andrew Fensome - Wayne PA, US
Joel Adam Goldberg - Philadelphia PA, US
Charles William Mann - Plymouth Meeting PA, US
David John O'Neill - Collegeville PA, US
Joseph Peter Sabatucci - Collegeville PA, US
Eugene Anthony Terefenko - Center Valley PA, US
Eugene John Trybulski - Huntingdon Valley PA, US
An Thien Vu - Pottstown PA, US
Puwen Zhang - Audubon PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/433
C07D 285/14
A61P 15/00
A61P 1/00
A61P 21/00
A61P 25/24
A61P 7/12
A61P 29/00

US Classification:

514361, 548126

Abstract:

The present invention is directed to hydroxy-substituted aryl sulfamide derivatives of formula I:or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

US Patent:

20090054392, Feb 26, 2009

Filed:

Aug 19, 2008

Appl. No.:

12/194235

Inventors:

Jeffrey Claude Pelletier - Lafayette Hill PA, US
Luciana de Araujo Felix - Broomall PA, US
Daniel Michael Green - Ambler PA, US
Diane Barbara Hauze - Wayne PA, US
Charles William Mann - Plymouth Meeting PA, US
John Francis Mehlmann - King of Prussia PA, US
Matthew Douglas Vera - Collegeville PA, US
Albert John Molinari - Pottstown PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/397
C07D 239/24
A61K 31/505
C07D 243/08
C07D 413/14
A61K 31/496
A61P 19/08
A61P 25/28
A61P 35/00
A61K 31/5377
A61K 31/551
C07D 403/02
A61K 31/55

US Classification:

5142102, 544330, 514275, 540575, 514218, 540601, 51421706, 544121, 5142358, 51425214

Abstract:

The present invention relates to naphthylpyrimidine analogs, methods of making naphthylpyrimidine analogs, compositions comprising a naphthylpyrimidine analog, and methods for treating canonical Wnt-β-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analog.