Charles Mcqueen

US Patent:

6844010, Jan 18, 2005

Filed:

Jul 18, 2000

Appl. No.:

09/618577

Inventors:

Jean A. Setterstrom - Alpharetta GA, US
John E. Van Hamont - Fort Meade MD, US
Robert H. Reid - Kensington MD, US
Elliot Jacob - Silver Spring MD, US
Ramasubbu Jeyanthi - Columbia MD, US
Edgar C. Boedeker - Chevy Chase MD, US
Charles E. McQueen - Olney MD, US
Daniel L. Jarboe - Silver Spring MD, US
Frederick Cassels - Ellicott City MD, US
William Brown - Denver CO, US
Curt Thies - Ballwin MO, US
Thomas R. Tice - Birmington AL, US
F. Donald Roberts - Dover MA, US
Phil Friden - Bedford MA, US

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 950

US Classification:

424501, 424486, 424499, 424422, 424491, 424493, 424426, 514570, 514 2, 514 12, 530350, 530300

Abstract:

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100/0 to 1/99.

US Patent:

6902743, Jun 7, 2005

Filed:

Apr 6, 1998

Appl. No.:

09/055505

Inventors:

Jean A. Setterstrom - Alpharetta GA, US
Thomas R. Tice - Birmingham AL, US
Elliot Jacob - Silver Spring MD, US
Robert H. Reid - Kensington MD, US
John van Hamont - West Point NY, US
Edgar C. Boedecker - Crownsville MD, US
Phil Friden - Bedford MA, US
F. Donald Roberts - Dover MA, US
Charles E. McQueen - Olney MD, US
Apurba Bhattacharjee - Kensington MD, US
Alan Cross - Chevy Chase MD, US
Jerald Sadoff - Washington DC, US
Wendell Zollinger - Silver Spring MD, US

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K009/14
A61K039/40
A61K009/48
A61K009/26
A61K009/16

US Classification:

424489, 424177, 424179, 424451, 424470, 424482, 424490

Abstract:

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.

US Patent:

63096692, Oct 30, 2001

Filed:

Jan 27, 1997

Appl. No.:

8/789734

Inventors:

Jean A. Setterstrom - Alpharetta GA
John E. Van Hamont - Fort Meade MD
Robert H. Reid - McComas CT
Elliot Jacob - Silver Spring MD
Ramasubbu Jeyanthi - Columbia MD
Edgar C. Boedeker - Chevy Chase MD
Charles E. McQueen - Olney MD
Daniel L. Jarboe - Silver Spring MD
Frederick Cassels - Ellicott City MD
William Brown - Denver CO
Curt Thies - Ballwin MO
Thomas R. Tice - Birmington AL
F. Donald Roberts - Dover MA
Phil Friden - Beford MA

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 952
A61K 4730

US Classification:

424486

Abstract:

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group and end-capped forms ranging in ratios from 100/0 to 1/99.