Charles G Nicholson

US Patent:

51494140, Sep 22, 1992

Filed:

Nov 20, 1986

Appl. No.:

6/932835

Inventors:

John S. C. Chiang - Mercerville NJ
Charles J. Nicholson - New Hope PA

Assignee:

FMC Corporation - Philadelphia PA

International Classification:

G25B 1112

US Classification:

204294

Abstract:

The invention is a porous gas diffusion electrode suitable for manufacturing hydrogen peroxide by the reduction of oxygen in an alkaline electrolyte and of a process for fabricating the electrode.

US Patent:

20210371811, Dec 2, 2021

Filed:

Aug 18, 2021

Appl. No.:

17/405168

Inventors:

- Telford PA, US
Jeremy J. HARRIS - Doylestown PA, US
Charles Brendan NICHOLSON - Coopersburg PA, US
Steven LU - Somerville MA, US
Brian GINN - Harleysville PA, US

International Classification:

C12N 5/00
A61L 27/18
C08G 63/685
C08K 5/17
C08G 63/91
A61L 27/50
C08K 3/32
C08K 3/26
A61L 27/58
C08L 67/00
A61L 27/38

Abstract:

A pH-modulating poly(glycerol sebacate) composition includes poly(glycerol sebacate) and at least one pH-modulating agent associated with the poly(glycerol sebacate). A process of making a pH-modulating poly(glycerol sebacate) composition includes forming a poly(glycerol sebacate) by a water-mediated reaction from glycerol and sebacic acid and associating at least one pH-modulating agent with the poly(glycerol sebacate). A process of modulating a pH of a buffered aqueous solution includes placing a pH-modulating poly(glycerol sebacate) composition in a buffered aqueous solution. The pH-modulating agent is released into the buffered aqueous solution during degradation of the poly(glycerol sebacate) to reduce a decrease in pH of the buffered aqueous solution caused by degradation of the poly(glycerol sebacate).

US Patent:

20210138073, May 13, 2021

Filed:

Jan 21, 2021

Appl. No.:

17/154164

Inventors:

- Telford PA, US
Charles Brendan NICHOLSON - Coopersburg PA, US
Peter D. GABRIELE - Frisco TX, US
Jared ELY - Quakertown PA, US
Brian GINN - Chalfont PA, US

International Classification:

A61K 47/59
A61K 47/34
A61L 24/06
C08K 3/013
C08G 63/12
C08J 3/12
A61P 19/00
C08L 67/00
A61L 27/48
A61L 27/18
A61L 27/56

Abstract:

A bone filling composition includes a bone filler. The bone filler includes microparticles of at least one elastomeric material. The at least one elastomeric material includes a poly(glycerol sebacate)-based thermoset. The poly(glycerol sebacate)-based thermoset may be porous thermoset poly(glycerol sebacate) flour, thermoset poly(glycerol sebacate) microspheres, or a combination thereof. In some embodiments, the bone filling composition is a bone filling composite that further includes a carrier material including a poly(glycerol sebacate) resin. A method of forming a bone filling composite includes selecting a bone filler and mixing the bone filler with a carrier material to form the bone filling composite. A method of treating a bony defect includes molding a bone filling composite and placing the bone filling composite in the bony defect. The bone filling composite includes a bone filler mixed with a carrier material.

US Patent:

20210121576, Apr 29, 2021

Filed:

Jan 5, 2021

Appl. No.:

17/141918

Inventors:

- Telford PA, US
Jeremy J. HARRIS - Doylestown PA, US
Carissa SMOOT - Harleysville PA, US
Charles Brendan NICHOLSON - Coopersburg PA, US
Stephanie REED - Conshohocken PA, US
Ryan R. SMALLEY - Lansdale PA, US

International Classification:

A61K 47/34
A61P 17/02
A61K 9/70
A61K 45/06
A61Q 19/00
A61K 8/37
A61K 8/85

Abstract:

A method of forming a skin care product includes combining at least one additive including at least one active ingredient with at least one glycerol-sebacate component having repeating units of (glycerol sebacate), water, a co-solvent, and at least one of an emulsifier, a surfactant, and a bodying agent to form the skin care product. A dermocosmetic composition includes at least one additive including at least one active ingredient and at least one glycerol-sebacate component having repeating units of (glycerol sebacate). A method of skin care includes applying a dermocosmetic composition to a skin surface.

US Patent:

20190255180, Aug 22, 2019

Filed:

Feb 21, 2019

Appl. No.:

16/281516

Inventors:

- Telford PA, US
Jeremy J. HARRIS - Doylestown PA, US
Carissa SMOOT - Harleysville PA, US
Charles Brendan NICHOLSON - Coopersburg PA, US
Stephanie REED - Conshohocken PA, US
Ryan R. SMALLEY - Lansdale PA, US

International Classification:

A61K 47/34
A61K 9/70
A61K 45/06
A61P 17/02

Abstract:

A method of forming a skin care product includes combining at least one additive including at least one active ingredient with at least one glycerol-sebacate component having repeating units of (glycerol sebacate), water, a co-solvent, and at least one of an emulsifier, a surfactant, and a bodying agent to form the skin care product. A dermocosmetic composition includes at least one additive including at least one active ingredient and at least one glycerol-sebacate component having repeating units of (glycerol sebacate). A method of skin care includes applying a dermocosmetic composition to a skin surface.

US Patent:

20190231890, Aug 1, 2019

Filed:

Jan 31, 2019

Appl. No.:

16/263064

Inventors:

- Telford PA, US
Charles Brendan NICHOLSON - Coopersburg PA, US
Peter D. GABRIELE - Frisco TX, US
Jared ELY - Quakertown PA, US
Brian GINN - Chalfont PA, US

International Classification:

A61K 47/59
A61K 47/34
A61L 24/06
C08K 3/013
C08L 67/00
C08G 63/12
C08J 3/12
A61P 19/00

Abstract:

A bone filling composition includes a bone filler. The bone filler includes microparticles of at least one elastomeric material. The at least one elastomeric material includes a poly(glycerol sebacate)-based thermoset. The poly(glycerol sebacate)-based thermoset may be porous thermoset poly(glycerol sebacate) flour, thermoset poly(glycerol sebacate) microspheres, or a combination thereof. In some embodiments, the bone filling composition is a bone filling composite that further includes a carrier material including a poly(glycerol sebacate) resin. A method of forming a bone filling composite includes selecting a bone filler and mixing the bone filler with a carrier material to form the bone filling composite. A method of treating a bony defect includes molding a bone filling composite and placing the bone filling composite in the bony defect. The bone filling composite includes a bone filler mixed with a carrier material.

US Patent:

20190218506, Jul 18, 2019

Filed:

Jan 17, 2019

Appl. No.:

16/250690

Inventors:

- Telford PA, US
Jeremy J. HARRIS - Doylestown PA, US
Charles Brendan NICHOLSON - Perkasie PA, US
Steven LU - Ambler PA, US
Brian GINN - Norristown PA, US

International Classification:

C12N 5/00

Abstract:

A pH-modulating poly(glycerol sebacate) composition includes poly(glycerol sebacate) and at least one pH-modulating agent associated with the poly(glycerol sebacate). A process of making a pH-modulating poly(glycerol sebacate) composition includes forming a poly(glycerol sebacate) by a water-mediated reaction from glycerol and sebacic acid and associating at least one pH-modulating agent with the poly(glycerol sebacate). A process of modulating a pH of a buffered aqueous solution includes placing a pH-modulating poly(glycerol sebacate) composition in a buffered aqueous solution. The pH-modulating agent is released into the buffered aqueous solution during degradation of the poly(glycerol sebacate) to reduce a decrease in pH of the buffered aqueous solution caused by degradation of the poly(glycerol sebacate).

US Patent:

20190218507, Jul 18, 2019

Filed:

Jan 17, 2019

Appl. No.:

16/250457

Inventors:

- Telford PA, US
Jeremy J. HARRIS - Doylestown PA, US
Charles Brendan NICHOLSON - Perkasie PA, US
Steven LU - Ambler PA, US
Jeffrey H. ROBERTSON - Sellersville PA, US
Gael PERON - Winston-Salem NC, US

International Classification:

C12N 5/00
C12M 1/00
C12M 1/12

Abstract:

A biocontainment vessel includes a vessel structure including a structural composition and an enhancement composition associated with the structural composition. The enhancement composition includes a co-polymer. The co-polymer is a poly(glycerol sebacate) or a poly(glycerol sebacate urethane). The enhancement composition may also include an augmentation agent associated with the co-polymer. The enhancement composition is located with respect to the structural composition such that the enhancement composition benefits biological cells contained in the biocontainment vessel. A composition includes a co-polymer and an augmentation agent contained by the co-polymer. A method of containing biological cells includes placing the biological cells in an augmented biocontainment vessel and storing them in the augmented biocontainment vessel under predetermined conditions. An augmented substrate includes a substrate and an enhancement composition coating a surface of the substrate.