Charles Lawrence Nicholson

US Patent:

51494140, Sep 22, 1992

Filed:

Nov 20, 1986

Appl. No.:

6/932835

Inventors:

John S. C. Chiang - Mercerville NJ
Charles J. Nicholson - New Hope PA

Assignee:

FMC Corporation - Philadelphia PA

International Classification:

G25B 1112

US Classification:

204294

Abstract:

The invention is a porous gas diffusion electrode suitable for manufacturing hydrogen peroxide by the reduction of oxygen in an alkaline electrolyte and of a process for fabricating the electrode.

US Patent:

20220257828, Aug 18, 2022

Filed:

May 9, 2022

Appl. No.:

17/662462

Inventors:

- Telford PA, US
Carissa Smoot - Harleysville PA, US
Dennis Shull - Phoenixville PA, US
Todd Crumbling - Perkasie PA, US
John D'Ottavio - Telford PA, US
Peter D. Gabriele - Frisco TX, US
Jeremy J. Harris - Doylestown PA, US
Charles Brendan Nicholson - Coopersburg PA, US
Jared Ely - Quakertown PA, US

International Classification:

A61L 27/18
A61L 27/54
A61K 31/522
B29C 67/24
B33Y 80/00

Abstract:

A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.

US Patent:

20210138109, May 13, 2021

Filed:

Jan 13, 2021

Appl. No.:

17/148130

Inventors:

- Telford PA, US
Carissa SMOOT - Harleysville PA, US
Dennis SHULL - Phoenixville PA, US
Todd CRUMBLING - Perkasie PA, US
John D'OTTAVIO - Telford PA, US
Peter D. GABRIELE - Frisco TX, US
Jeremy J. HARRIS - Doylestown PA, US
Charles Brendan NICHOLSON - Coopersburg PA, US
Jared ELY - Quakertown PA, US

International Classification:

A61L 27/18
A61L 27/54
A61K 31/522
B29C 67/24
B33Y 80/00

Abstract:

A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.

US Patent:

20210024686, Jan 28, 2021

Filed:

Oct 8, 2020

Appl. No.:

17/065971

Inventors:

- Telford PA, US
Carissa SMOOT - Harleysville PA, US
Charles Brendan NICHOLSON - Coopersburg PA, US
Jeremy J. HARRIS - Doylestown PA, US

International Classification:

C08G 63/12
A61K 47/55
C08G 63/81
C08G 63/133
C08G 63/123
C08G 63/06
C08G 63/78

Abstract:

A method includes combining an alcohol-pharmaceutical conjugate, a polyol, and an aqueous liquid in a vessel. The alcohol-pharmaceutical conjugate includes a pharmaceutical compound having at least one carboxyl group attached to the polyol by an ester bond. The method also includes adding an acid monomer to the vessel and heating and removing water from the vessel to produce the polymeric material. The polymeric material includes a polyester copolymer of the acid monomer and the polyol and the pharmaceutical compound.

US Patent:

20200101165, Apr 2, 2020

Filed:

Dec 4, 2019

Appl. No.:

16/702832

Inventors:

- Telford PA, US
Carissa SMOOT - Harleysville PA, US
Peter D. GABRIELE - Frisco TX, US
Jeremy J. HARRIS - Doylestown PA, US
Charles Brendan NICHOLSON - Coopersburg PA, US
Steven LU - Cambridge MA, US

International Classification:

A61K 47/59
A61K 47/34
C08J 3/12
C08G 63/12
C08L 67/00
C08K 3/013

Abstract:

A filler material of a thermoset resin of a diacid/polyol, such as PGS is provided. The filler useful in forming composites, such as those in which the filler and a resin matrix are of the same material to provide a homogenous polymeric composition. Composites in which at least one of the matrix, the filler or both are PGS are also provided. Methods of forming such filler materials and composites are also disclosed. The composites allow extrusion process to form articles from materials that would not otherwise be capable of being extruded.

US Patent:

20200061240, Feb 27, 2020

Filed:

Aug 21, 2019

Appl. No.:

16/547175

Inventors:

- Telford PA, US
Carissa SMOOT - Harleysville PA, US
Dennis SHULL - Phoenixville PA, US
Todd CRUMBLING - Perkasie PA, US
John D'OTTAVIO - Telford PA, US
Peter D. GABRIELE - Frisco TX, US
Jeremy J. HARRIS - Doylestown PA, US
Charles Brendan NICHOLSON - Coopersburg PA, US
Jared ELY - Quakertown PA, US

International Classification:

A61L 27/18
A61L 27/54
A61K 31/522
B33Y 80/00
B29C 67/24

Abstract:

A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.

US Patent:

20190016854, Jan 17, 2019

Filed:

Jul 11, 2018

Appl. No.:

16/032733

Inventors:

- Telford PA, US
Carissa SMOOT - Harleysville PA, US
Charles Brendan NICHOLSON - Coopersburg PA, US
Jeremy J. HARRIS - Buckingham PA, US

International Classification:

C08G 63/12
C08G 63/06
C08G 63/78

Abstract:

A method includes combining an alcohol-pharmaceutical conjugate, a polyol, and an aqueous liquid in a vessel. The alcohol-pharmaceutical conjugate includes a pharmaceutical compound having at least one carboxyl group attached to the polyol by an ester bond. The method also includes adding an acid monomer to the vessel and heating and removing water from the vessel to produce the polymeric material. The polymeric material includes a polyester copolymer of the acid monomer and the polyol and the pharmaceutical compound.

US Patent:

20170246316, Aug 31, 2017

Filed:

Feb 24, 2017

Appl. No.:

15/442055

Inventors:

- Telford PA, US
Carissa SMOOT - Harleysville PA, US
Peter D. GABRIELE - Frisco TX, US
Jeremy J. HARRIS - Buckingham PA, US
Charles Brendan NICHOLSON - Coopersburg PA, US
Steven LU - Ambler PA, US

International Classification:

A61K 47/48
A61K 47/34
C08G 63/12

Abstract:

A filler material of a thermoset resin of a diacid/polyol, such as PGS is provided. The filler useful in forming composites, such as those in which the filler and a resin matrix are of the same material to provide a homogenous polymeric composition. Composites in which at least one of the matrix, the filler or both are PGS are also provided. Methods of forming such filler materials and composites are also disclosed. The composites allow extrusion process to form articles from materials that would not otherwise be capable of being extruded.