Charles S Pugh

US Patent:

6579696, Jun 17, 2003

Filed:

Jun 7, 1995

Appl. No.:

08/482191

Inventors:

Mohammed Saleh Shekhani - Madison WI
Robert W. Schatz - New Glarus WI
Charles Pugh - Middleton WI
Nicholas Panasik, Jr. - Madison WI
Douglas Stafford - Madison WI

Assignee:

Promega Corporation - Madison WI

International Classification:

C12P 2106

US Classification:

435 681, 514 2, 530300, 530333, 530350, 5303917

Abstract:

Compositions and methods are described for preventing and treating sepsis in humans and other animals. Surgical patients, low birth weight infants, burn and trauma victims, as well as other individuals at risk can be treated prophylactically. Methods for treating acute infections with advantages over current therapeutic approaches are provided.

US Patent:

20020012658, Jan 31, 2002

Filed:

Jun 16, 1999

Appl. No.:

09/334477

Inventors:

JAMES A. WILLIAMS - LINCOLN NE, US
LISA MARIE BYRNE - STOUGHTON WI, US
CHARLES S.G. PUGH - MADISON WI, US

International Classification:

A61K048/00
A01N063/00

US Classification:

424/093200

Abstract:

The present invention includes methods for generating neutralizing antitoxin directed against verotoxins. In preferred embodiments, the antitoxin directed against these toxins is produced in avian species using soluble recombinant verotoxin proteins. This antitoxin is designed so as to be administrable in therapeutic amounts and may be in any form (i.e., as a solid or in aqueous solution). These antitoxins are useful in the treatment of humans and other animals intoxicated with at least one bacterial toxin, as well as for preventive treatment, and diagnostic assays to detect the presence of toxin in a sample.

US Patent:

55457215, Aug 13, 1996

Filed:

Dec 17, 1993

Appl. No.:

8/169701

Inventors:

Sean B. Carroll - Cottage Grove WI
Joseph R. Firca - Vernon Hills IL
Charles Pugh - Madison WI
Nisha V. Padhye - Madison WI

Assignee:

Ophidian Pharmaceuticals, Inc. - Madison WI

International Classification:

C07K 1600
C07K 1700

US Classification:

5303917

Abstract:

Compositions and methods are described for preventing and treating sepsis in humans and other animals. Surgical patients, low birth weight infants, burn and trauma victims, as well as other individuals at risk can be treated prophylactically. Methods for treating acute infections with advantages over current therapeutic approaches are provided. Conjugates and methods of making conjugates for the prevention and treatment of sepsis are described.