Described herein are methods and compositions for killing or preventing the growth of microbes. It has been discovered that a class of porphyrins can kill or prevent the growth of microbes. The porphyrins can be used in a number of different applications where microbes grow.
Novel Antibacterial And Herbicidal Compounds And System For Screening The Same
C. Poulter - Salt Lake City UT, US Frederick Hahn - Paia HI, US Rita Cornish - Salt Lake City UT, US Charles Testa - Salt Lake City UT, US
International Classification:
C12N001/21
US Classification:
435/252330, 435/252340
Abstract:
A transgenic bacterial host cell that can be used as a screen for novel antibiotics and herbicides is provided. The genome of the transgenic bacterial host cell comprises disruptions in a first endogenous gene in the MEP pathway) and a transgene that functionally replaces the disrupted first gene. In other embodiments, the genome comprises a disruption in a first endogenous gene in the MEP pathway and a second endogenous gene which is located downstream of the first gene in the MEP pathway. A transgene that functionally replaces the disrupted downstream gene is cloned into the host cell. A mini operon containing the essential genes for the MVA pathway may also be cloned into the host cell. The transgenic host cell may be used in a method for screening compounds for antibiotic and herbicidal properties. The agents determined by the screening method may be used to kill bacteria or plants.
Substituted Internal Vinyl-Boronic Acids And Boronic Acid Derivatives
Shivanand K. Math - North Logan UT, US Homayoun H. Mokri - North Logan UT, US James B. LaMunyon - Richmond UT, US Dustin R. Cefalo - Hyrum UT, US Charles A. Testa - Salt Lake City UT, US
Disclosed herein are vinyl-bromides, vinyl-boronic acids and vinyl-boronic acid derivatives useful as synthetic intermediates for the preparation of therapeutic agents. Also disclosed are methods of synthesis of vinyl-bromides, vinyl-boronic acids and vinyl-boronic acid derivatives.
- Salt Lake City UT, US Hariprasada R. Kanna Reddy - Salt Lake City UT, US Travis J. Haussener - Salt Lake City UT, US Charles A. Testa - North Salt Lake UT, US Seth Grant - West Jordan UT, US Carmela Napolitano - Verona, IT Fabio Maria Sabbatini - Verona, IT
The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.
Compositions For Killing Or Preventing The Growth Of Microbes
Described herein are methods and compositions for killing or preventing the growth of microbes. It has been discovered that a class of porphyrins can kill or prevent the growth of microbes. The porphyrins can be used in a number of different applications where microbes grow.
Name / Title
Company / Classification
Phones & Addresses
Charles Testa Owner
Island Kitchens & Baths General Contractors-Single-Family Houses
60 W Main St, Canaan Lake, NY 11772 Website: islandkitchens.com
Charles Testa Owner
Island Management Services Ltd Carpentry Work
60 W Main St, Canaan Lake, NY 11772
Charles Testa Director Anti-infective Development
Echelon Biosciences, Inc Commercial Physical and Biological Research