Cheng Ji

US Patent:

58885463, Mar 30, 1999

Filed:

Aug 28, 1995

Appl. No.:

8/519738

Inventors:

Cheng Ji - Los Angeles CA
Guido Guglielmi - Santa Monica CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 910

US Classification:

424484

Abstract:

A multipurpose ointment (MPOc) in a semisolid-semiliquid form and a multipurpose particle (MPPc) in a solid soft particulate form are prepared by combining a matrix base in a aqueous solution with a liquid oil base and added modifiers and medications to form either an ointment or suspension of particles for endovascular disposition for embolizing abnormal microvascular beds or nidi. The ointment or particles are formed from a albumin (human serum or chicken egg) matrix or equivalent material or combination of the same in an aqueous solution, typically contrast-medium solution, which has been emulsified with a radiopaque oil base such as ETHIODOL, and then heated to modify the mobility, viscosity, deformability, elasticity, surface tension and friction along with the inclusion of medications and modifiers for the desired physical characteristics and biological end effects.

US Patent:

60247185, Feb 15, 2000

Filed:

Sep 4, 1997

Appl. No.:

8/923609

Inventors:

Hank H. Chen - St. Louis MO
Cheng Ji - Los Angeles CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 1720
A61B 1732

US Classification:

604 22

Abstract:

An ultrasound catheter comprises a coaxial cable of electrical conductors with a piezoelectric element at its distal end. The piezoelectric element is shaped and disposed according to the desired ultrasonic field. When an electrical signal from a signal generator is connected to the electrical conductors, the piezoelectric element mechanically deforms in response and generates ultrasonic energy. An alternative embodiment of the present invention is a hollow tubular catheter of flexible polymer has at its distal end a cylindrical piezoelectric element connected to electrical conductors running the length of the catheter. The piezoelectric cylinder may be tapered, segmented, shortened, etc. according to the desired focusing of the ultrasonic field, which is preferably forwardly focused. In either embodiment the catheter is threaded through a patient's vasculature and brought in close proximity to a vascular occlusion.

US Patent:

58940227, Apr 13, 1999

Filed:

Oct 7, 1997

Appl. No.:

8/946608

Inventors:

Cheng Ji - Los Angeles CA
Guido Guglielmi - Santa Monica CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61F 1300
A61K 914

US Classification:

424422

Abstract:

The present invention is an endovascular embolic composition. The embolic composition comprises a hydrophilic insoluble matrix having a microscopic mesh-like structure. The voids or intricacies of the matrix enclose droplets of aqueous solution as well as liquid oil. This structure is essentially equivalent to a "gel" structure with the insoluble matrix including both aqueous and oil droplets within its mesh. In creating the matrix a liquid oil base is mixed with an aqueous solution of a matrix base. The matrix base comprises an organic polymer such as a protein like albumin or its equivalent dissolved in an aqueous solution which may contain additional solutes. The matrix base solution is mixed and emulsified with the liquid oil base at a volume ratio ranging between about 1-to-1 and 1-to-5 respectively. To create the embolic composition the matrix base is then precipitated or cross-linked to form a gel with a mesh-like microscopic structure in which insoluble matrix surrounds and entraps both aqueous fluid and liquid oil. Preferably sclerifying agents are included within the composition so that scar tissue will develop to permanently occlude the embolized vasculature.

US Patent:

20140186436, Jul 3, 2014

Filed:

Jul 6, 2012

Appl. No.:

14/131159

Inventors:

Otto O. Yang - Los Angeles CA, US
Yunfeng Lu - Culver City CA, US
Cheng Ji - Los Angeles CA, US
Ming Yan - Encino CA, US
Yang Liu - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 38/44

US Classification:

424451, 424 942, 4352625

Abstract:

The invention disclosed herein includes nanocomplexes that are designed include enzymes that have complementary functional attributes and methods for using these nanocomplexes. Illustrative examples include nanocomplexes that comprise both an alcohol oxidase enzyme as well as a catalase enzyme. These nanocomplexes can be used in methods designed to lower blood alcohol levels in vivo, and/or to break down the toxic byproducts of alcohol metabolism. Consequently these nanocomplexes can be used to treat a variety of conditions resulting from the consumption of alcohol, including for example, acute alcohol intoxication.