Cheryl I Champion

US Patent:

6677439, Jan 13, 2004

Filed:

Oct 13, 1998

Appl. No.:

09/172070

Inventors:

David R. Blanco - Beverly Hills CA
James N. Miller - Northbridge CA
Michael A. Lovett - Los Angeles CA
Cheryl I. Champion - Culver City CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07K 100

US Classification:

530412, 530350, 435 691, 435 6, 435 911, 435 915, 435170, 435 795, 435 71, 536 231, 536 243, 4242621, 514263

Abstract:

Antigenic rare outer membrane proteins of Spirochaetaceae are obtained from organisms extracted from infected tissue by a novel process of isolation utilizing a discontinuous Ficoll gradient separation, release of outer membrane in a low isotonic and low pH buffer and identification of outer membrane by use of a lipid soluble dye. Four antigenic rare outer membrane proteins of subsp. useful in diagnosis and prophylaxis of syphilis are provided. Also provided is the amino acid sequence of a rare outer membrane protein of subsp. and the nucleotide sequence encoding it.

US Patent:

6685945, Feb 3, 2004

Filed:

Aug 19, 1997

Appl. No.:

08/914350

Inventors:

David A. Haake - Culver City CA
David R. Blanco - Beverly Hills CA
Cheryl I. Champion - Culver City CA
Michael A. Lovett - Los Angeles CA
James N. Miller - Northridge CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 3902

US Classification:

4241901, 4242341, 530350, 530825, 430200

Abstract:

An antigenic preparation is provided which contains a 31 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism.

US Patent:

8124109, Feb 28, 2012

Filed:

May 15, 2009

Appl. No.:

12/467255

Inventors:

Valerie A. Kickhoefer - Sherman Oaks CA, US
Leonard H. Rome - Tarzana CA, US
Kathleen A. Kelly - Pacific Palisades CA, US
Cheryl I. Champion - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 39/118

US Classification:

4242631, 4241931, 514 11

Abstract:

Methods and compositions are provided herein for immunizing a subject against Chlamydial genital infection by administering to the subject an effective amount of a Chlamydial immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. In some aspects, the vault-like-particles are administered to the nasal mucosa. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity at mucosal surfaces while reducing inflammation associated with infection.

US Patent:

8318182, Nov 27, 2012

Filed:

Feb 10, 2012

Appl. No.:

13/371260

Inventors:

Valerie A. Kickhoefer - Sherman Oaks CA, US
Leonard H. Rome - Tarzana CA, US
Kathleen A. Kelly - Pacific Palisades CA, US
Cheryl I. Champion - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 39/118

US Classification:

4242531, 4241931, 514 11

Abstract:

Methods and compositions are provided herein for immunizing a subject against Chlamydial genital infection by administering to the subject an effective amount of a Chlamydial immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. In some aspects, the vault-like-particles are administered to the nasal mucosa. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity at mucosal surfaces while reducing inflammation associated with infection.

US Patent:

20030162208, Aug 28, 2003

Filed:

Dec 17, 2002

Appl. No.:

10/322391

Inventors:

David Haake - Culver City CA, US
David Blanco - Beverly Hills CA, US
Cheryl Champion - Culver City CA, US
Michael Lovett - Los Angeles CA, US
James Miller - Northridge CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, a California corporation

International Classification:

C12Q001/68
G01N033/554
G01N033/569
C07K014/195
C07H021/04
C12N015/74

US Classification:

435/006000, 435/007320, 435/320100, 435/069300, 435/252300, 530/350000, 536/023500

Abstract:

An antigenic preparation is provided which contains a 31 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism.

US Patent:

20130078273, Mar 28, 2013

Filed:

Nov 26, 2012

Appl. No.:

13/685552

Inventors:

Valerie A. Kickhoefer - Sherman Oaks CA, US
Leonard H. Rome - Tarzana CA, US
Kathleen A. Kelly - Pacific Palisades CA, US
Cheryl I. Champion - Los Angeles CA, US

International Classification:

A61K 39/118

US Classification:

42419711, 4242631

Abstract:

Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.

US Patent:

20130122037, May 16, 2013

Filed:

Jan 10, 2013

Appl. No.:

13/737963

Inventors:

Valerie A. Kickhoefer - Sherman Oaks CA, US
Leonard H. Rome - Tarzana CA, US
Kathleen A. Kelly - Pacific Palisades CA, US
Cheryl I. Champion - Los Angeles CA, US

International Classification:

A61K 39/118

US Classification:

42419711

Abstract:

Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.

US Patent:

55589936, Sep 24, 1996

Filed:

Jun 17, 1994

Appl. No.:

8/261825

Inventors:

Cheryl I. Champion - Culver City CA
Michael A. Lovett - Los Angeles CA
David A. Haake - Culver City CA
James N. Miller - Northridge CA
David R. Blanco - Northridge CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07H 2102
C07H 2104
C12N 121
C12N 1570
C12P 2100
C12Q 168

US Classification:

435 6

Abstract:

A polynucleotide encoding a 17-kD virulence protein, called EppA, from Borrelia burgdorferi is provided. The protein encoded by the polynucleotide of the invention is useful immunologically as a vaccine for Lyme borreliosis caused by B. burgdorferi. Methods and kits for detection of EppA polynucleotide are also provided.