Cheryl A Lobo

US Patent:

20090074783, Mar 19, 2009

Filed:

Sep 15, 2008

Appl. No.:

12/210900

Inventors:

Cheryl Lobo - Syosset NY, US
Estrella Montero - Madrid, ES

Assignee:

New York Blood Center - New York NY

International Classification:

A61K 39/395
C07K 14/00
C07H 21/00
C07K 16/00
A61P 33/02
A61K 31/7052
C12Q 1/02
C12Q 1/68

US Classification:

4241391, 530350, 536 237, 5303879, 435 29, 435 6, 514 44

Abstract:

Provided is an isolated and purified protein produced by a naturally occurring sp. comprising an amino acid sequence at least 90% identical to SEQ ID NO:1 and an isolated and purified nucleic acid encoding the above protein. Additionally provided is an isolated and purified nucleic acid comprising at least 20 nucleotides having a sequence 100% identical to a portion of SEQ ID NO:2 or its complement. Further provided is an antibody preparation comprising an antibody that specifically binds to the above protein. Also provided are methods of diagnosing a sp. infection in a mammal, methods of determining whether a blood preparation is contaminated with a sp., methods of determining whether a blood preparation is contaminated with a sp., and methods of treating a mammal infected with a sp., the method comprising inhibiting the production or activity of the protein comprising an amino acid sequence at least 90% identical to SEQ ID NO:1 by the sp. in the mammal. Additionally provided are methods of screening a compound for treating an infection by a sp.

US Patent:

20100196380, Aug 5, 2010

Filed:

Feb 18, 2010

Appl. No.:

12/707953

Inventors:

Cheryl Lobo - Syosset NY, US
Estrella Montero - Madrid, ES

Assignee:

NEW YORK BLOOD CENTER - New York NY

International Classification:

A61K 39/395
A61K 31/7088
A61P 31/04

US Classification:

4241391, 514 44 R, 514 44 A

Abstract:

Provided is an isolated and purified protein produced by a naturally occurring sp. comprising an amino acid sequence at least 90% identical to SEQ ID NO:1 and an isolated and purified nucleic acid encoding the above protein. Additionally provided is an isolated and purified nucleic acid comprising at least 20 nucleotides having a sequence 100% identical to a portion of SEQ ID NO:2 or its complement. Further provided is an antibody preparation comprising an antibody that specifically binds to the above protein. Also provided are methods of diagnosing a sp. infection in a mammal, methods of determining whether a blood preparation is contaminated with a sp., methods of determining whether a blood preparation is contaminated with a sp., and methods of treating a mammal infected with a sp., the method comprising inhibiting the production or activity of the protein comprising an amino acid sequence at least 90% identical to SEQ ID NO:1 by the sp. in the mammal. Additionally provided are methods of screening a compound for treating an infection by a sp.