Chi N Tu from San Diego, CA, age 65

view source

Location:

San Diego, CA

Industry:

Biotechnology

Work:

Paxvax, Inc.
Qa Manager

Purine Nucleoside Modifications By Palladium Catalyzed Methods And Compounds Produced
view source
US Patent:

6355787, Mar 12, 2002
Filed:

Jan 31, 2000
Appl. No.:

09/495429
Inventors:

Jeffrey T. Beckvermit - Berthoud CO
Chi Tu - Louisville CO
Assignee:

Gilead Sciences, Inc. - Foster City CA
International Classification:

C07H 2102
US Classification:

536 231, 536 2711, 536 276, 536 2761, 536 2762, 536 2763, 536 2781, 544264
Abstract:

This invention discloses a method for the preparation of 2â-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to the method of the invention and oligonucleotides containing said modified pyrimidines and purines.

Nucleoside Modifications By Palladium Catalyzed Methods
view source
US Patent:

6512106, Jan 28, 2003
Filed:

Jan 15, 2002
Appl. No.:

10/047786
Inventors:

Jeffrey T. Beckvermit - Berthoud CO
Chi Tu - Louisville CO
Assignee:

Gilead Sciences, Inc. - Foster City CA
International Classification:

C07H 1916
US Classification:

536 2671, 536 2762, 536 2711, 544264
Abstract:

This invention discloses a method for the preparation of 2â-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to the method of the invention and oligonucleotides containing said modified pyrimidines and purines.

Nucleoside Modifications By Palladium Catalyzed Methods
view source
US Patent:

6846918, Jan 25, 2005
Filed:

Jan 24, 2003
Appl. No.:

10/351468
Inventors:

Jeffrey T. Beckvermit - Berthoud CO, US
Chi Tu - Louisville CO, US
Assignee:

Gilead Sciences, Inc. - Foster City CA
International Classification:

C07H 1900
C07H 2100
US Classification:

536 221, 536 231, 536 253, 536 281, 536 282, 536 284, 536 286, 536 287
Abstract:

This invention discloses a method for the preparation of 2′-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to the method of the invention and oligonucleotides containing said modified pyrimidines and purines.

Non-Nucleotide Composition And Method For Inhibiting Platelet Aggregation
view source
US Patent:

7335648, Feb 26, 2008
Filed:

May 5, 2005
Appl. No.:

11/124619
Inventors:

Robert Plourde, Jr. - Chapel Hill NC, US
Sammy R. Shaver - Chapel Hill NC, US
Paul S. Watson - Carrboro NC, US
José L. Boyer - Chapel Hill NC, US
Chi Tu - San Diego CA, US
Melwyn A. Abreo - Jamul CA, US
Lorenzo J. Alfaro-Lopez - San Marcos CA, US
Yangbo Feng - Palm Beach Gardens FL, US
Daniel F. Harvey - San Diego CA, US
Assignee:

Inspire Pharmaceuticals, Inc. - Durham NC
International Classification:

A01N 43/04
A61K 31/70
C07H 19/16
US Classification:

514 46, 536 2723
Abstract:

This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.

Pyridazine Derivatives And Their Use As Therapeutic Agents
view source
US Patent:

7335658, Feb 26, 2008
Filed:

Jul 29, 2004
Appl. No.:

10/901563
Inventors:

Nagasree Chakka - Burnaby, CA
Mikhail Chafeev - Vancouver, CA
Sultan Chowdhury - Scarborough, CA
Jian-Min Fu - Burnaby, CA
Duanjie Hou - Burnaby, CA
Rajender Kamboj - Burnaby, CA
Vishnumurthy Kodumuru - Burnaby, CA
Shifeng Liu - Port Coquitlam, CA
Vandna Raina - Vancouver, CA
Shaoyi Sun - Vancouver, CA
Serguei Sviridov - Burnaby, CA
Michael D Winther - Vancouver, CA
Zaihui Zhang - Vancouver, CA
Melwyn Abreo - Jamul CA, US
Mark W Holladay - San Diego CA, US
Wenbao Li - San Diego CA, US
Sengen Sun - San Diego CA, US
Chi Tu - San Diego CA, US
Heinz W Gschwend - Santa Rosa CA, US
Assignee:

Xenon Pharmaceuticals Inc. - Burnaby, British Columbia
International Classification:

C07D 403/04
C07D 403/14
A61K 31/497
US Classification:

51425202, 544238
Abstract:

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I):.

Non-Nucleotide Compositions And Method For Inhibiting Platelet Aggregation
view source
US Patent:

7368438, May 6, 2008
Filed:

Oct 21, 2004
Appl. No.:

10/971766
Inventors:

Robert Plourde, Jr. - Chapel Hill NC, US
Sammy R. Shaver - Chapel Hill NC, US
José L. Boyer - Chapel Hill NC, US
Melwyn A. Abreo - Jamul CA, US
Lorenzo J. Alfaro-Lopez - San Marcos CA, US
Yangbo Feng - Palm Beach Gardens FL, US
Daniel F. Harvey - San Diego CA, US
Chi Tu - San Diego CA, US
Assignee:

Inspire Pharmaceuticals, Inc. - Durham NC
International Classification:

A01N 43/04
A61K 31/70
C07H 19/16
US Classification:

514 46, 536 2723
Abstract:

This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Yreceptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formula I and III-XI, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds according to Formula I and III-XI.

Piperazine Derivatives And Their Use As Therapeutic Agents
view source
US Patent:

7456180, Nov 25, 2008
Filed:

Jul 29, 2004
Appl. No.:

10/567009
Inventors:

Serguei Sviridov - Burnaby, CA
Vishnumurthy Kodumuru - Burnaby, CA
Shifeng Liu - Port Coquitlam, CA
Melwyn Abreo - Jamul CA, US
Michael D. Winther - Vancouver, CA
Heinz W. Gschwend - Santa Rosa CA, US
Rajender Kamboj - Burnaby, CA
Shaoyi Sun - Vancouver, CA
Mark W. Holladay - San Diego CA, US
Wenbao Li - San Diego CA, US
Chi Tu - San Diego CA, US
Assignee:

Xenon Pharmaceuticals Inc. - Burnaby, British Columbia
International Classification:

A61K 31/497
C07D 241/02
US Classification:

51425211, 544357
Abstract:

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R, R, R, R, R, R, R, R, R, R, R, R, Rand Ra are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Non-Nucleotide Composition And Method For Inhibiting Platelet Aggregation
view source
US Patent:

7592445, Sep 22, 2009
Filed:

Jan 4, 2008
Appl. No.:

11/969539
Inventors:

Robert Plourde, Jr. - Chapel Hill NC, US
Sammy R. Shaver - Chapel Hill NC, US
Paul S. Watson - Carrboro NC, US
José L. Boyer - Chapel Hill NC, US
Chi Tu - San Diego CA, US
Melwyn A. Abreo - Jamul CA, US
Lorenzo J. Alfaro-Lopez - San Marcos CA, US
Yangbo Feng - Palm Beach Gardens FL, US
Daniel F. Harvey - San Diego CA, US
Assignee:

Inspire Pharmaceuticals, Inc. - Durham NC
International Classification:

C07H 19/16
A01N 43/04
A61K 31/70
US Classification:

536 273, 514 46
Abstract:

This invention is directed to compounds of Formulae III and V, useful for treating diseases or conditions associated with platelet aggregation.