- Wilmington DE, US Stephanie K. Springer - Washington DC, US Chi B. Vu - Arlington MA, US
Assignee:
GlaxoSmithKline, LLC - Wilmington DE
International Classification:
A61K 31/5377 A61K 31/5025 C07D 487/04
US Classification:
5142332, 544236, 514248, 544118, 435375
Abstract:
Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided, are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
Marshall Montgomery Village, MD 1997 to 1998 CashierMontgomery College Rockville, MD Nov 1996 to May 1997 BookkeeperMcDonalds Derwood, MD 1994 to 1996 Cashier
Education:
Richard Montgomery High School Rockville, MD 1993 to 1996 High School Diploma
Dr. Vu graduated from the Louisiana State University School of Medicine at New Orleans in 1998. She works in Arlington, TX and specializes in Family Medicine. Dr. Vu is affiliated with John Peter Smith Health Network.