Chris L Stumpf

US Patent:

7418352, Aug 26, 2008

Filed:

Jun 30, 2006

Appl. No.:

11/480254

Inventors:

Robert Stephen Plumb - Milford MA, US
Chris Lee Stumpf - Uxbridge MA, US
Marc V. Gorenstein - Needham MA, US

International Classification:

G06F 19/00
G06F 11/30
H01J 49/00

US Classification:

702 32, 702182, 250281, 250282

Abstract:

Disclosed herein is a method of analyzing three-dimensional data obtained from a chromatography/spectrometry process, in particular an LC/MS process using a two-dimensional multi-variant statistical analysis. The LC portion permits separation of analytes within a sample. The information obtained from such a procedure typically depends on retention time (R). As the analytes progress through the system, they enter the MS region of the LC/MS system. There they are ionized and a mass detector then detects these ionized species. The information procured from this procedure is generally reported as intensity for a corresponding m/z value. Therefore, an LC/MS system provides at least three pieces of information. Principle component analysis (PCA) is a robust method of multi-variant analysis of this type of data between different samples. However, typically, PCA analysis is performed using only two-dimensional data.

US Patent:

7564027, Jul 21, 2009

Filed:

Feb 9, 2004

Appl. No.:

10/545332

Inventors:

Jeffrey W. Finch - Mendon MA, US
Chris L. Stumpf - Milford MA, US
Bruce J. Compton - Lexington MA, US

Assignee:

Waters Investments Limited - New Castle DE

International Classification:

H01J 49/00

US Classification:

250288, 250286, 250282, 250340, 2503411, 2503412, 250281, 250423 R, 250284, 250290, 435 6, 4352872, 435 71, 4352871, 4352887, 428357, 428364, 4283044, 428446, 4281951, 436 86, 436173, 436174, 436525, 436518, 427 211, 422 8205, 422 8201, 356301, 356244

Abstract:

The present invention provides a device, system, and associated methods to actively or passively sample air by directing it onto the surface of a porous light-absorbing semiconductor, for example, a desorption/ionization on porous silicon (“DIOS”) chip. Upon adsorption of an analyte, the surface may be analyzed directly by laser desorption/ionization time-of-flight mass spectrometry. Because the process of laser desorption/ionization and subsequent mass detection does not require elevated temperatures, thermal degradation of analytes is avoided.

US Patent:

7645984, Jan 12, 2010

Filed:

Feb 11, 2005

Appl. No.:

10/588967

Inventors:

Marc V. Gorenstein - Needham MA, US
Robert S. Plumb - Milford MA, US
Chris L. Stumpf - Uxbridge MA, US

Assignee:

Waters Technologies Corporation - Milford MA

International Classification:

H01J 49/00
B01D 59/44
G06F 19/00
G01R 23/16

US Classification:

250281, 250282, 250288, 250397, 702 76, 702196, 702 28, 702 32

Abstract:

Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix.

US Patent:

7938961, May 10, 2011

Filed:

Aug 2, 2005

Appl. No.:

11/195232

Inventors:

Robert S. Plumb - Milford MA, US
Chris L. Stumpf - Uxbridge MA, US
Jennifer H. Granger - Northborough MA, US

Assignee:

Waters Technologies Corporation - Milford MA

International Classification:

B01D 15/08

US Classification:

2101982, 210656

Abstract:

Disclosed herein are an apparatus and method for effectuating increased chromatographic efficiency in a capillary column by employing a retaining frit disposed within an analytical capillary. By disposing the retaining frit within the analytic capillary, the void volume is significantly minimized. The columns and methods described herein produce a simplified analytical capillary and retaining frit apparatus that provides greater chromatographic efficiency. Additionally, the column of the instant invention maintains chromatographic fidelity by reducing the transfer diameter as well as facilitating fluidic connections in situ.

US Patent:

8017908, Sep 13, 2011

Filed:

Dec 18, 2009

Appl. No.:

12/641812

Inventors:

Marc V. Gorenstein - Needham MA, US
Robert S. Plumb - Milford MA, US
Chris L. Stumpf - Uxbridge MA, US

Assignee:

Waters Technologies Corporation - Milford MA

International Classification:

H01J 49/26
H01J 49/00
B01D 59/44

US Classification:

250282, 250281, 250288, 250397, 702 76, 702 28, 702 32, 702196

Abstract:

Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix.

US Patent:

20050127287, Jun 16, 2005

Filed:

Nov 16, 2004

Appl. No.:

10/989533

Inventors:

Robert Plumb - Milford MA, US
Chris Stumpf - Uxbridge MA, US
Marc Gorenstein - Needham MA, US

Assignee:

WATERS INVESTMENTS LIMITED - New Castle DE

International Classification:

H01J049/00

US Classification:

250281000

Abstract:

Disclosed herein is a method of analyzing three-dimensional data obtained from a chromatography/spectrometry process, in particular an LC/MS process using a two-dimensional multi-variant statistical analysis. The LC portion permits separation of analytes within a sample. The information obtained from such a procedure typically depends on retention time (R). As the analytes progress through the system, they enter the MS region of the LC/MS system. There they are ionized and a mass detector then detects these ionized species. The information procured from this procedure is generally reported as intensity for a corresponding m/z value. Therefore, an LC/MS system provides at least three pieces of information. Principle component analysis (PCA) is a robust method of multi-variant analysis of this type of data between different samples. However, typically, PCA analysis is performed using only two-dimensional data. Therefore, it is expected that at least one parameter of data obtained from a LC/MS operation is lost, however, the methods disclosed herein preserves all three mathematical dimensions.

US Patent:

20060171849, Aug 3, 2006

Filed:

Dec 15, 2005

Appl. No.:

11/300955

Inventors:

Jennifer Granger - Northborough MA, US
Robert Plumb - Milford MA, US
Chris Stumpf - Uxbridge MA, US
Jeffery Finch - Mendon MA, US

Assignee:

WATERS INVESTMENTS LIMITED - New Castle DE

International Classification:

B01L 3/00

US Classification:

422099000

Abstract:

Disclosed herein is an apparatus designed to prevent cross-contamination of a fluid along the surface of a platform like a laser desorption target or multi-well plate. In particular, the apparatus comprises a cover slip that is disposed in apposition to the platform. This cover slip has an upper surface and a lower surface, wherein the lower surface is in apposition to the platform. Optionally, the cover slip has one or more defined orifices that extend from the upper surface through to the lower surface such that fluid communication is maintained from the upper surface of the cover slip to the surface of the platform interfacing with the lower surface of the cover slip.