Christine A Collins

US Patent:

6818772, Nov 16, 2004

Filed:

Feb 21, 2003

Appl. No.:

10/372359

Inventors:

Philip R. Kym - Grayslake IL
Kresna Hartandi - Gurnee IL
Ju Gao - Gurnee IL
Kathleen M. Phelan - Gurnee IL
Christine A. Collins - Skokie IL
Anil Vasudevan - Gurnee IL
Mary K. Verzal - Burlington WI

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D21538

US Classification:

546160, 546162, 514313

Abstract:

The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

US Patent:

6989392, Jan 24, 2006

Filed:

Jun 12, 2003

Appl. No.:

10/460139

Inventors:

Christine A. Collins - Skokie IL, US
Ju Gao - Gurnee IL, US
Philip R. Kym - Grayslake IL, US
Jared C. Lewis - Oakland CA, US
Andrew J. Souers - Evanston IL, US
Anil Vasudevan - Gurnee IL, US
Dariusz Wodka - Waukegan IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31/47
C07D 215/38
C07D 215/44

US Classification:

514312, 546159, 546161, 546162

Abstract:

The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor and are useful for the prevention or treatment of eating disorders, weight gain and obesity.

US Patent:

7049307, May 23, 2006

Filed:

Dec 22, 2004

Appl. No.:

11/020464

Inventors:

Andrew J. Souers - Evanston IL, US
Christine A. Collins - Skokie IL, US
Ju Gao - Gurnee IL, US
Andrew S. Judd - Grayslake IL, US
Philip R. Kym - Libertyville IL, US
Mathew M. Mulhern - Hainesville IL, US
Hing L. Sham - Vernon Hills IL, US
Dariusz Wodka - Plainsboro NJ, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31/55
A61K 31/416
A61K 31/5377
A61K 31/438
A61K 31/454

US Classification:

51421021, 5142345, 514278, 514322, 514403, 51421709, 540603, 544119, 546 19, 546199, 5483601

Abstract:

The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

US Patent:

7071182, Jul 4, 2006

Filed:

Dec 22, 2004

Appl. No.:

11/022453

Inventors:

Andrew J. Souers - Evanston IL, US
Christine A. Collins - Skokie IL, US
Ju Gao - Gurnee IL, US
Andrew S. Judd - Grayslake IL, US
Philip R. Kym - Libertyville IL, US
Mathew M. Mulhern - Hainesville IL, US
Hing L. Sham - Vernon Hills IL, US
Dariusz Wodka - Monmouth Junction NJ, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31/55
A61K 31/5377
A61K 31/454
A61K 31/416
A61K 31/4439

US Classification:

51421021, 51421709, 5142345, 51425406, 514322, 514338, 514403, 540603, 544119, 544357, 544371, 546199, 5462757, 5483601

Abstract:

The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

US Patent:

7252992, Aug 7, 2007

Filed:

Jun 17, 2003

Appl. No.:

10/463123

Inventors:

Dennis G. Fry - Gurnee IL, US
Christine Ann Collins - Skokie IL, US
Brian D. Dayton - Libertyville IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12N 5/00
C12N 5/10
G01N 33/50
G01N 33/566

US Classification:

435325, 435 721

Abstract:

The subject invention relates to a novel cell line, referred to as T42402I3. 4. 2, and to uses of this cell line. For example, the cell line may be used in the production of recombinant melanin concentrating hormone (MCH) receptor protein and in the identification of antagonists, inverse agonists and agonists to the receptor.

US Patent:

20050137187, Jun 23, 2005

Filed:

Dec 23, 2003

Appl. No.:

10/744571

Inventors:

Andrew Souers - Evanston IL, US
Christine Collins - Skokie IL, US
Ju Gao - Gurnee IL, US
Andrew Judd - Grayslake IL, US
Philip Kym - Grayslake IL, US
Mathew Mulhern - Hainesville IL, US
Hing Sham - Vernon Hills IL, US
Dariusz Wodka - Waukegan IL, US

International Classification:

A61K031/55
A61K031/454
A61K031/416
C07D043/02

US Classification:

514217090, 514322000, 514406000, 540603000, 546199000, 548362500

Abstract:

The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

US Patent:

20050137243, Jun 23, 2005

Filed:

Dec 23, 2003

Appl. No.:

10/744188

Inventors:

Andrew Souers - Evanston IL, US
Christine Collins - Skokie IL, US
Ju Gao - Gurnee IL, US
Andrew Judd - Grayslake IL, US
Philip Kym - Grayslake IL, US
Mathew Mulhern - Hainesville IL, US
Hing Sham - Vernon Hills IL, US
Anil Vasudevan - Union Grove WI, US
Dariusz Wodka - Waukegan IL, US

International Classification:

A61K031/416
C07D231/56

US Classification:

514406000, 548362500

Abstract:

The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

US Patent:

20050187387, Aug 25, 2005

Filed:

Feb 25, 2004

Appl. No.:

10/787694

Inventors:

John Lynch - Kenosha WI, US
Christine Collins - Skokie IL, US
Jennifer Freeman - Grayslake IL, US
Ju Gao - Gurnee IL, US
Rajesh Iyengar - Lindenhurst IL, US
Andrew Judd - Grayslake IL, US
Philip Kym - Grayslake IL, US
Mathew Mulhern - Hainesville IL, US
Hing Sham - Vernon Hills IL, US
Andrew Souers - Evanston IL, US
Gang Zhao - Northbrook IL, US

International Classification:

B32B027/02

US Classification:

544063000

Abstract:

The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.