Susan Lindquist - Chicago IL, US Christine Queitsch - North Cambridge MA, US Todd Sangster - Chicago IL, US
International Classification:
A01H001/00 C12Q001/68
US Classification:
800/289000, 435/006000
Abstract:
The present invention regards a method of unmasking or revealing genetic variation in eukaryotic organisms, such as plants, to eukaryotic organisms, particularly plants, produced by the method, and eukaryotic organisms, particularly plants, that exhibit a phenotype (phenotype trait) masked by Hsp90 function (activity). Specifically, the present invention is directed to the detecting genetic variation in a plant by interfering with the Hsp90 buffer system. More specifically, endogenous Hsp90 activity is inhibited by drugs or genetic manipulation that results in the manifestation of pre-existing yet otherwise undetected genetic variations, such as polymorphisms.
Susan Lindquist - Chicago IL, US Christine Queitsch - Chicago IL, US Elizabeth Vierling - Tuscon AZ, US
International Classification:
A01H005/00 C12N015/82
US Classification:
800/298000, 800/278000
Abstract:
A transgenic plant having increased stress tolerance, such as thermotolerance, comprises a Hsp100 family nucleic acid sequence. The invention is also directed to methods of producing products from transgenic Hsp100 plants.