Christine E Stelmach

US Patent:

6645961, Nov 11, 2003

Filed:

Mar 4, 1998

Appl. No.:

09/045885

Inventors:

Chung Y. Lui - Lansdale PA
Drazen Ostovic - Lansdale PA
Ashok V. Katdare - Norristown PA
Christine Stelmach - Tinton Falls NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 31535

US Classification:

5142315, 514252, 514255, 514311

Abstract:

This invention relates to a dry granulation capsule formulation of the HIV protease inhibitor, indinavir sulfate, which is useful in the treatment of AIDS, ARC or HIV infection. Processes for making the oral formulation are also disclosed.

US Patent:

6939964, Sep 6, 2005

Filed:

Jun 24, 2004

Appl. No.:

10/891749

Inventors:

Louis S. Crocker - Belle Mead NJ, US
Andrew S. Thompson - Mountainside NJ, US
Christine Stelmach - Westfield NJ, US
Steven D. Young - Lansdale PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D265/18

US Classification:

544 92

Abstract:

The instant invention describes a method for crystallizing (−)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40 C. and 50 C.

US Patent:

20030208070, Nov 6, 2003

Filed:

May 29, 2003

Appl. No.:

10/447690

Inventors:

Louis Crocker - Belle Mead NJ, US
Joseph Kukura - Somerset NJ, US
Andrew Thompson - Mountainside NJ, US
Christine Stelmach - Westfield NJ, US
Steven Young - Landsdale PA, US

International Classification:

C07D265/12

US Classification:

544/092000

Abstract:

The instant invention describes a method for crystallizing (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40 C. and 50 C.

US Patent:

20040058976, Mar 25, 2004

Filed:

Jul 16, 2003

Appl. No.:

10/466877

Inventors:

Christine Stelmach - Westfield NJ, US

International Classification:

A61K038/04
A61K031/405
A61K031/21

US Classification:

514/414000, 514/419000, 514/019000, 514/513000

Abstract:

This invention relates a formulation comprising potent potassium channel blockers or pharmaceutically acceptable salts thereof in combination with peanut oil for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

20060009641, Jan 12, 2006

Filed:

Sep 1, 2005

Appl. No.:

11/217931

Inventors:

Louis Crocker - Belle Mead NJ, US
Joseph Kukura - Somerset NJ, US
Andrew Thompson - Mountainside NJ, US
Christine Stelmach - Westfield NJ, US
Steven Young - Lansdale PA, US

International Classification:

C07D 265/18

US Classification:

544092000

Abstract:

The instant invention describes a method for crystallizing (−)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40 C. and 50 C.

US Patent:

6639071, Oct 28, 2003

Filed:

Oct 19, 2001

Appl. No.:

10/000537

Inventors:

Louis S. Crocker - Belle Mead NJ
Andrew S. Thompson - Mountainside NJ
Christine Stelmach - Westfield NJ
Steven D. Young - Lansdale PA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D26518

US Classification:

544 92

Abstract:

The instant invention describes a method for crystallizing (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one from a solvent and anti-solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40Â C. and 50Â C.